Maofeng Wang1,2, Jun Zhang1, Qiaoying Ji3, Qiongfang Yang3, Fenhua Zhao4, Weimin Li5, Hao-Teng Chang6,7, Xinyou Xie1. 1. Department of Clinical Laboratory, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310000, China. 2. Department of Biomedical Sciences Laboratory, Affiliated Dongyang Hospital of Wenzhou Medical University, Dongyang, Zhejiang, 322100, China. 3. Department of Respiratory, Affiliated Dongyang Hospital of Wenzhou Medical University, Dongyang, Zhejiang, 322100, China. 4. Department of Radiology, Affiliated Dongyang Hospital of Wenzhou Medical University, Dongyang, Zhejiang, 322100, China. 5. Department of Cardiology, Affiliated Dongyang Hospital of Wenzhou Medical University, Dongyang, Zhejiang, 322100, China. 6. Graduate Institute of Basic Medical Science, College of Medicine, China Medical University, Taichung City, 40402, Taiwan. 7. Department of Computer Science and Information Engineering, Asia University, Taichung City 41354, Taiwan.
Abstract
BACKGROUND: Platelets play an important role in the pathogenesis of pulmonary embolism (PE). We aimed to investigate whether there is a correlation between platelet distribution width (PDW) and chronic obstructive pulmonary disease (COPD) patients with PE. METHODS: We conducted a retrospective study using 126 COPD patients with PE and 51 COPD patients without PE. Blood biomarkers, including PDW and d-dimer, were included. Odds ratios (OR) associated with PDW and interactions with d-dimer, SpO2 were estimated for PE. RESULTS: PDW was higher in the COPD patients with PE group (p = 0.007). A higher PDW had a significantly increased risk of PE than a lower PDW (adjusted OR 2.724, 95% CI: 1.290-5.753). CONCLUSION: PDW are elevated in COPD patients with PE and are associated with the risk of PE.
BACKGROUND: Platelets play an important role in the pathogenesis of pulmonary embolism (PE). We aimed to investigate whether there is a correlation between platelet distribution width (PDW) and chronic obstructive pulmonary disease (COPD) patients with PE. METHODS: We conducted a retrospective study using 126 COPDpatients with PE and 51 COPDpatients without PE. Blood biomarkers, including PDW and d-dimer, were included. Odds ratios (OR) associated with PDW and interactions with d-dimer, SpO2 were estimated for PE. RESULTS: PDW was higher in the COPDpatients with PE group (p = 0.007). A higher PDW had a significantly increased risk of PE than a lower PDW (adjusted OR 2.724, 95% CI: 1.290-5.753). CONCLUSION: PDW are elevated in COPDpatients with PE and are associated with the risk of PE.
Entities:
Keywords:
chronic obstructive pulmonary disease; platelet distribution width; pulmonary embolism