Zbigniew Samochocki1, Jarosław Bogaczewicz2, Anna Sysa-Jędrzejowska3, Daniel P McCauliffe4,5, Ewa Kontny6, Anna Wozniacka2. 1. Department of Dermatology, Medical University of Warsaw, Warsaw, Poland. 2. Department of Dermatology and Venereology, Medical University of Lodz, Lodz, Poland. 3. Department of Social Sciences, University of Social Sciences, Lodz, Poland. 4. Department of Dermatology, University of North Carolina, Chapel Hill, NC, USA. 5. Private Practice, Rutland, VT, USA. 6. Department of Pathophysiology and Immunology, Institute of Rheumatology, Warsaw, Poland.
Abstract
BACKGROUND: Vascular endothelial growth factor (VEGF) was found increased in the stratum corneum of patients with atopic dermatitis (AD). However, its potential pathogenic role(s) in AD needs further clarification. OBJECTIVE: The aim of this study was to determine whether VEGF serum levels correlate with other selected cytokine levels and features of AD. METHODS: VEGF and other cytokine levels were measured in 83 patients with AD and in a control group and then correlated with clinical and laboratory parameters of AD. RESULTS: The mean serum concentrations of VEGF and tumor necrosis factor α were significantly higher in patients with AD than in the control group, whereas the mean interleukin eight serum level was lower. VEGF concentrations correlated with the severity of AD as expressed by SCORAD index and objective SCORAD. CONCLUSION: VEGF could be regarded as a potentially important mediator in the pathogenesis of AD, as VEGF levels correlate somewhat with AD severity.
BACKGROUND:Vascular endothelial growth factor (VEGF) was found increased in the stratum corneum of patients with atopic dermatitis (AD). However, its potential pathogenic role(s) in AD needs further clarification. OBJECTIVE: The aim of this study was to determine whether VEGF serum levels correlate with other selected cytokine levels and features of AD. METHODS:VEGF and other cytokine levels were measured in 83 patients with AD and in a control group and then correlated with clinical and laboratory parameters of AD. RESULTS: The mean serum concentrations of VEGF and tumor necrosis factor α were significantly higher in patients with AD than in the control group, whereas the mean interleukin eight serum level was lower. VEGF concentrations correlated with the severity of AD as expressed by SCORAD index and objective SCORAD. CONCLUSION:VEGF could be regarded as a potentially important mediator in the pathogenesis of AD, as VEGF levels correlate somewhat with AD severity.
Authors: Robert A Byers; Raman Maiti; Simon G Danby; Elaine J Pang; Bethany Mitchell; Matt J Carré; Roger Lewis; Michael J Cork; Stephen J Matcher Journal: Biomed Opt Express Date: 2018-03-29 Impact factor: 3.732
Authors: E Roekevisch; K Szegedi; D P Hack; M E Schram; P C J M Res; J D Bos; M M G Leeflang; R M Luiten; S Kezic; P I Spuls; M A Middelkamp-Hup Journal: J Eur Acad Dermatol Venereol Date: 2020-02-05 Impact factor: 6.166