Literature DB >> 2656275

Inotropic effects of endothelin in ferret ventricular myocardium.

A M Shah1, M J Lewis, A H Henderson.   

Abstract

The characteristics of the inotropic response to endothelin were studied in isolated ferret papillary muscle preparations. Endothelin (0.1-10 nM) induced concentration-dependent positive inotropic effects. At 10 nM, isometric tension increased by 17%, maximum rate of tension development by 18%, maximum velocity of unloaded shortening by 23% and peak isotonic shortening by 11%. Time to peak isometric tension and half isometric relaxation time were unaltered by endothelin. This pattern of change is similar to that of elevating extracellular calcium concentration.

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Year:  1989        PMID： 2656275     DOI： 10.1016/0014-2999(89)90208-2

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  11 in total

1.  Endothelin enhances the contractile responsiveness of adult rat ventricular myocytes to calcium by a pertussis toxin-sensitive pathway.

Authors:  R A Kelly; H Eid; B K Krämer; M O'Neill; B T Liang; M Reers; T W Smith
Journal:  J Clin Invest       Date:  1990-10       Impact factor: 14.808

2.  Factors released from endocardium of the ferret and pig modulate myocardial contraction.

Authors:  J A Smith; A M Shah; M J Lewis
Journal:  J Physiol       Date:  1991-08       Impact factor: 5.182

3.  Pharmacological characteristics of endothelin receptors in the rabbit ventricular myocardium: the nonselective endothelin receptor antagonist PD 145065 antagonizes the positive inotropic effect of endothelin-3 but not of endothelin-1.

Authors:  I Norota; M Endoh
Journal:  Mol Cell Biochem       Date:  1996 Jul-Aug       Impact factor: 3.396

4.  Direct positive inotropic and vasoconstrictor effects of endothelin.

Authors:  M R Siegfried; N Aoki; D Mulloy; A M Lefer
Journal:  Heart Vessels       Date:  1990       Impact factor: 2.037

5.  Role of Na+/Ca2+ exchange in endothelin-1-induced increases in Ca2+ transient and contractility in rabbit ventricular myocytes: pharmacological analysis with KB-R7943.

Authors:  H T Yang; K Sakurai; H Sugawara; T Watanabe; I Norota; M Endoh
Journal:  Br J Pharmacol       Date:  1999-04       Impact factor: 8.739

6.  Influence of endothelin 1 on human atrial myocardium--myocardial function and subcellular pathways.

Authors:  M Meyer; S Lehnart; B Pieske; K Schlottauer; S Munk; C Holubarsch; H Just; G Hasenfuss
Journal:  Basic Res Cardiol       Date:  1996 Jan-Feb       Impact factor: 17.165

7.  PKC-ε mediates multiple endothelin-1 actions on systolic Ca2+ and contractility in ventricular myocytes.

Authors:  Misuk Kang; Ka Young Chung
Journal:  Biochem Biophys Res Commun       Date:  2012-06-12       Impact factor: 3.575

8.  Role of endogenous endothelin in myocardial and coronary endothelial injury after ischaemia and reperfusion in rats: studies with bosentan, a mixed ETA-ETB antagonist.

Authors:  V Richard; N Kaeffer; M Hogie; C Tron; T Blanc; C Thuillez
Journal:  Br J Pharmacol       Date:  1994-11       Impact factor: 8.739

Review 9.  Endothelin and myocardial ischemia.

Authors:  D Hasdai; R Kornowski; A Battler
Journal:  Cardiovasc Drugs Ther       Date:  1994-08       Impact factor: 3.727

10.  Mechanical effects of ET-1 in cardiomyocytes isolated from normal and heart-failed rabbits.

Authors:  E J Kelso; R F Geraghty; B J McDermott; E R Trimble; D P Nicholls; B Silke
Journal:  Mol Cell Biochem       Date:  1996 Apr 12-26       Impact factor: 3.396
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