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Literature DB >> 26562407

The existence of 5-hydroxymethylcytosine and 5-formylcytosine in both DNA and RNA in mammals.

Hao-Ying Zhang¹, Jun Xiong¹, Bao-Ling Qi¹, Yu-Qi Feng¹, Bi-Feng Yuan¹.

Abstract

We developed a novel strategy by oxidation-derivatization combined mass spectrometry analysis for the determination of 5-hydroxymethylcytosine and 5-formylcytosine in both DNA and RNA. We reported the presence of 5-formylcytosine in RNA of mammals and found that ascorbic acid and hydroquinone can increase the oxidation of 5-methylcytosine to 5-hydroxymethylcytosine in DNA and RNA.

Entities: Chemical

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Year: 2016 PMID： 26562407 DOI： 10.1039/c5cc07354e

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

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Cited

26 in total

Review 1. Chemical and structural effects of base modifications in messenger RNA.

Authors: Emily M Harcourt; Anna M Kietrys; Eric T Kool
Journal: Nature Date: 2017-01-18 Impact factor: 49.962

Review 2. Formation and repair of oxidatively generated damage in cellular DNA.

Authors: Jean Cadet; Kelvin J A Davies; Marisa Hg Medeiros; Paolo Di Mascio; J Richard Wagner
Journal: Free Radic Biol Med Date: 2017-01-02 Impact factor: 7.376

3. A novel malic acid-enhanced method for the analysis of 5-methyl-2'-deoxycytidine, 5-hydroxymethyl-2'-deoxycytidine, 5-methylcytidine and 5-hydroxymethylcytidine in human urine using hydrophilic interaction liquid chromatography-tandem mass spectrometry.

Authors: Cheng Guo; Cong Xie; Qin Chen; Xiaoji Cao; Mengzhe Guo; Shu Zheng; Yinsheng Wang
Journal: Anal Chim Acta Date: 2018-07-03 Impact factor: 6.558

Review 4. Post-transcriptional gene regulation by mRNA modifications.

Authors: Boxuan Simen Zhao; Ian A Roundtree; Chuan He
Journal: Nat Rev Mol Cell Biol Date: 2016-11-03 Impact factor: 94.444

5. Rapid and Efficient Spatiotemporal Monitoring of Normal and Aberrant Cytosine Methylation within Intact Zebrafish Embryos.

Authors: Sarah Avila-Barnard; David C Volz
Journal: J Vis Exp Date: 2022-08-18 Impact factor: 1.424

The existence of 5-hydroxymethylcytosine and 5-formylcytosine in both DNA and RNA in mammals.

Review 1. Chemical and structural effects of base modifications in messenger RNA.

Review 2. Formation and repair of oxidatively generated damage in cellular DNA.

3. A novel malic acid-enhanced method for the analysis of 5-methyl-2'-deoxycytidine, 5-hydroxymethyl-2'-deoxycytidine, 5-methylcytidine and 5-hydroxymethylcytidine in human urine using hydrophilic interaction liquid chromatography-tandem mass spectrometry.

Review 4. Post-transcriptional gene regulation by mRNA modifications.

5. Rapid and Efficient Spatiotemporal Monitoring of Normal and Aberrant Cytosine Methylation within Intact Zebrafish Embryos.

6. Reactivity-dependent profiling of RNA 5-methylcytidine dioxygenases.

Review 7. Regulation of pluripotency and reprogramming by RNA binding proteins.

Review 8. Mechanisms of epitranscriptomic gene regulation.

Review 9. RNA 5-methylcytosine modification and its emerging role as an epitranscriptomic mark.

Review 10. Epigenetics: Roles and therapeutic implications of non-coding RNA modifications in human cancers.