Literature DB >> 26561719

Varitatin A, a Highly Modified Fatty Acid Amide from Penicillium variabile Cultured with a DNA Methyltransferase Inhibitor.

Xueqian He1, Zhenzhen Zhang1, Yinghan Chen1, Qian Che1, Tianjiao Zhu1, Qianqun Gu1, Dehai Li1.   

Abstract

A new, highly modified fatty acid amide, varitatin A (1), was isolated from the fungus Penicillium variabile HXQ-H-1 cultivated with the DNA methyltransferase inhibitor 5-azacytidine. The structure including the absolute configuration of 1 was established by analysis of NMR and MS data, together with chemical degradation and Mosher's method based on MPA esters. Compound 1 showed cytotoxicity against HCT-116 cells with an IC50 value of 2.8 μM and also inhibited the effects of protein tyrosine kinases.

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Year:  2015        PMID： 26561719     DOI： 10.1021/acs.jnatprod.5b00742

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  10 in total

1.  Enzyme-Catalyzed Inverse-Electron Demand Diels-Alder Reaction in the Biosynthesis of Antifungal Ilicicolin H.

Authors:  Zhuan Zhang; Cooper S Jamieson; Yi-Lei Zhao; Dehai Li; Masao Ohashi; K N Houk; Yi Tang
Journal:  J Am Chem Soc       Date:  2019-03-26       Impact factor: 15.419

2.  Antimicrobial Metabolites Produced by Penicillium mallochii CCH01 Isolated From the Gut of Ectropis oblique, Cultivated in the Presence of a Histone Deacetylase Inhibitor.

Authors:  Shuxiang Zhang; Han Fang; Caiping Yin; Chaoling Wei; Jingwei Hu; Yinglao Zhang
Journal:  Front Microbiol       Date:  2019-10-02       Impact factor: 5.640

3.  Chromosome-Level Comprehensive Genome of Mangrove Sediment-Derived Fungus Penicillium variabile HXQ-H-1.

Authors:  Ling Peng; Liangwei Li; Xiaochuan Liu; Jianwei Chen; Chengcheng Shi; Wenjie Guo; Qiwu Xu; Guangyi Fan; Xin Liu; Dehai Li
Journal:  J Fungi (Basel)       Date:  2019-12-23

Review 4.  Regulation of Secondary Metabolism in the Penicillium Genus.

Authors:  Christelle El Hajj Assaf; Chrystian Zetina-Serrano; Nadia Tahtah; André El Khoury; Ali Atoui; Isabelle P Oswald; Olivier Puel; Sophie Lorber
Journal:  Int J Mol Sci       Date:  2020-12-12       Impact factor: 5.923

Review 5.  Cryptic Metabolites from Marine-Derived Microorganisms Using OSMAC and Epigenetic Approaches.

Authors:  Cristina Pinedo-Rivilla; Josefina Aleu; Rosa Durán-Patrón
Journal:  Mar Drugs       Date:  2022-01-18       Impact factor: 5.118

Review 6.  Marine-Derived Penicillium Species as Producers of Cytotoxic Metabolites.

Authors:  Sen Liu; Mingzhi Su; Shao-Jiang Song; Jee H Jung
Journal:  Mar Drugs       Date:  2017-10-24       Impact factor: 5.118

Review 7.  Lead Compounds from Mangrove-Associated Microorganisms.

Authors:  Elena Ancheeva; Georgios Daletos; Peter Proksch
Journal:  Mar Drugs       Date:  2018-09-07       Impact factor: 5.118

Review 8.  Extending the "One Strain Many Compounds" (OSMAC) Principle to Marine Microorganisms.

Authors:  Stefano Romano; Stephen A Jackson; Sloane Patry; Alan D W Dobson
Journal:  Mar Drugs       Date:  2018-07-23       Impact factor: 5.118

9.  Epigenetic Agents Trigger the Production of Bioactive Nucleoside Derivatives and Bisabolane Sesquiterpenes From the Marine-Derived Fungus Aspergillus versicolor.

Authors:  Jing-Shuai Wu; Guang-Shan Yao; Xiao-Hui Shi; Saif Ur Rehman; Ying Xu; Xiu-Mei Fu; Xiu-Li Zhang; Yang Liu; Chang-Yun Wang
Journal:  Front Microbiol       Date:  2020-01-30       Impact factor: 5.640

Review 10.  Extremophilic Fungi from Marine Environments: Underexplored Sources of Antitumor, Anti-Infective and Other Biologically Active Agents.

Authors:  Lesley-Ann Giddings; David J Newman
Journal:  Mar Drugs       Date:  2022-01-10       Impact factor: 5.118
  10 in total

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