Literature DB >> 26559847

Human Herpesvirus 6A U14 Is Important for Virus Maturation.

Junko Mori1, Huamin Tang2, Akiko Kawabata1, Masato Koike3, Yasuko Mori4.   

Abstract

Human herpesvirus 6A (HHV-6A) U14 is a virion protein with little known function in virus propagation. Here, we elucidated its function by constructing and analyzing U14-mutated viruses. We found that U14 is essential for HHV-6A propagation. We then constructed a mutant virus harboring dysfunctional U14. This virus showed severely reduced growth and retarded maturation. Taken together, these data indicate that U14 plays an important role during HHV-6A maturation.
Copyright © 2016, American Society for Microbiology. All Rights Reserved.

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Year:  2015        PMID： 26559847      PMCID： PMC4719638          DOI： 10.1128/JVI.02492-15

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  36 in total

1.  The 85-kilodalton phosphoprotein (pp85) of human herpesvirus 7 is encoded by open reading frame U14 and localizes to a tegument substructure in virion particles.

Authors:  A Stefan; P Secchiero; T Baechi; W Kempf; G Campadelli-Fiume
Journal:  J Virol       Date:  1997-08       Impact factor: 5.103

2.  Functional map of human cytomegalovirus AD169 defined by global mutational analysis.

Authors:  Dong Yu; Maria C Silva; Thomas Shenk
Journal:  Proc Natl Acad Sci U S A       Date:  2003-09-30       Impact factor: 11.205

3.  Herpes simplex virus 1 tegument protein US11 downmodulates the RLR signaling pathway via direct interaction with RIG-I and MDA-5.

Authors:  Junji Xing; Shuai Wang; Rongtuan Lin; Karen L Mossman; Chunfu Zheng
Journal:  J Virol       Date:  2012-02-01       Impact factor: 5.103

Review 4.  Viral and host control of cytomegalovirus maturation.

Authors:  Ritesh Tandon; Edward S Mocarski
Journal:  Trends Microbiol       Date:  2012-05-23       Impact factor: 17.079

5.  Human herpesvirus 6B genome sequence: coding content and comparison with human herpesvirus 6A.

Authors:  G Dominguez; T R Dambaugh; F R Stamey; S Dewhurst; N Inoue; P E Pellett
Journal:  J Virol       Date:  1999-10       Impact factor: 5.103

6.  Human herpesvirus 6 latent infection in patients with glioma.

Authors:  Jing Chi; Bin Gu; Chun Zhang; Guangyong Peng; Feng Zhou; Yun Chen; Guofeng Zhang; Yidi Guo; Dandan Guo; Jian Qin; Jinfeng Wang; Lingyun Li; Fang Wang; Genyan Liu; Fangyi Xie; Dongju Feng; Hong Zhou; Xingxu Huang; Shiqiang Lu; Yingxia Liu; Weixing Hu; Kun Yao
Journal:  J Infect Dis       Date:  2012-09-07       Impact factor: 5.226

7.  The interaction of the HSV-1 tegument proteins pUL36 and pUL37 is essential for secondary envelopment during viral egress.

Authors:  Barbara J Kelly; Rudolf Bauerfeind; Anne Binz; Beate Sodeik; Andrea S Laimbacher; Cornel Fraefel; Russell J Diefenbach
Journal:  Virology       Date:  2014-02-22       Impact factor: 3.616

8.  Human herpesvirus 6 subtype A-associated myocarditis with 'apical ballooning'.

Authors:  Boris Bigalke; Karin Klingel; Andreas E May; Reinhard Kandolf; Meinrad Gawaz Gawaz
Journal:  Can J Cardiol       Date:  2007-04       Impact factor: 5.223

9.  Human herpesvirus 6 (HHV-6) reactivation and HHV-6 encephalitis after allogeneic hematopoietic cell transplantation: a multicenter, prospective study.

Authors:  Masao Ogata; Takako Satou; Jun-ichi Kadota; Noriyuki Saito; Takashi Yoshida; Hirokazu Okumura; Toshimitsu Ueki; Koji Nagafuji; Shinichi Kako; Nobuhiko Uoshima; Mitsuru Tsudo; Hidekazu Itamura; Takahiro Fukuda
Journal:  Clin Infect Dis       Date:  2013-05-30       Impact factor: 9.079

10.  Human herpesvirus-6 induces MVB formation, and virus egress occurs by an exosomal release pathway.

Authors:  Yasuko Mori; Masato Koike; Eiko Moriishi; Akiko Kawabata; Huamin Tang; Hiroko Oyaizu; Yasuo Uchiyama; Koichi Yamanishi
Journal:  Traffic       Date:  2008-07-11       Impact factor: 6.215
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  3 in total

1.  Human Herpesvirus 6A Tegument Protein U14 Induces NF-κB Signaling by Interacting with p65.

Authors:  Salma Aktar; Jun Arii; Lidya Handayani Tjan; Mitsuhiro Nishimura; Yasuko Mori
Journal:  J Virol       Date:  2021-09-22       Impact factor: 5.103

2.  Crystal Structure of Human Herpesvirus 6B Tegument Protein U14.

Authors:  Bochao Wang; Mitsuhiro Nishimura; Huamin Tang; Akiko Kawabata; Nora F Mahmoud; Zahra Khanlari; Daizo Hamada; Hiroki Tsuruta; Yasuko Mori
Journal:  PLoS Pathog       Date:  2016-05-06       Impact factor: 6.823

3.  HHV-8-unrelated primary effusion-like lymphoma associated with clonal loss of inherited chromosomally-integrated human herpesvirus-6A from the telomere of chromosome 19q.

Authors:  Enjie Zhang; Victoria E Cotton; Alberto Hidalgo-Bravo; Yan Huang; Adam J Bell; Ruth F Jarrett; Gavin S Wilkie; Andrew J Davison; Ellie P Nacheva; Reiner Siebert; Aneela Majid; Inga Kelpanides; Sandrine Jayne; Martin J Dyer; Nicola J Royle
Journal:  Sci Rep       Date:  2016-03-07       Impact factor: 4.379
  3 in total

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