| Literature DB >> 22962688 |
Jing Chi1, Bin Gu, Chun Zhang, Guangyong Peng, Feng Zhou, Yun Chen, Guofeng Zhang, Yidi Guo, Dandan Guo, Jian Qin, Jinfeng Wang, Lingyun Li, Fang Wang, Genyan Liu, Fangyi Xie, Dongju Feng, Hong Zhou, Xingxu Huang, Shiqiang Lu, Yingxia Liu, Weixing Hu, Kun Yao.
Abstract
The etiology of glioma remains unclear so far. Human herpesvirus 6 (HHV-6) might be associated with glioma, but there is no direct evidence to support this. High percentages of HHV-6 DNA and protein were detected in tissue from gliomas, compared with normal brain tissue. In addition, a strain of HHV-6A was isolated from the fluid specimens from glioma cysts. High levels of interleukin 6 (IL-6), interleukin 8 (IL-8), tumor necrosis factor α, and transforming growth factor β (TGF-β) were detected in the cyst fluid specimens from HHV-6-positive patients with glioma. Furthermore, HHV-6A infection promoted IL-6, IL-8, and TGF-β production in astrocyte cultures. Our studies strongly suggest the involvement of HHV-6 infection in the pathogenesis of glioma.Entities:
Mesh：
Substances：
Year: 2012 PMID： 22962688 DOI： 10.1093/infdis/jis513
Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226