| Literature DB >> 26559750 |
Taeko K Naruse1, Daisuke Sakurai1, Hitoshi Ohtani1, Gaurav Sharma2, Surendra K Sharma3, Madhu Vajpayee4, Narinder K Mehra2, Gurvinder Kaur2, Akinori Kimura1.
Abstract
Human APOBEC3H (A3H) is a member of APOBEC cytidine deaminase family intensively constraining the HIV-1 replication. A3H is known to be polymorphic with different protein stability and anti-HIV-1 activity in vitro. We recently reported that A3H haplotypes composed of two functional polymorphisms, rs139292 (N15del) and rs139297 (G105R), were associated with the susceptibility to HIV-1 infection in Japanese. To confirm the association of A3H and HIV-1 infection in another ethnic group, a total of 241 HIV-1-infected Indian individuals and ethnic-matched 286 healthy controls were analyzed for the A3H polymorphisms. The frequency of 15del allele was high in the HIV-1-infected subjects as compared with the controls (0.477 vs 0.402, odds ratio (OR)=1.36, P=0.014). Haplotype analysis showed that the frequencies of 15del-105R was high (0.475 vs 0.400, OR=1.36, permutation P=0.037) in the HIV-1-infected subjects, confirming the association of A3H polymorphisms with the susceptibility to HIV-1 infection.Entities:
Mesh：
Substances：
Year: 2015 PMID： 26559750 DOI： 10.1038/jhg.2015.136
Source DB: PubMed Journal: J Hum Genet ISSN： 1434-5161 Impact factor: 3.172