Literature DB >> 26559006

Mobile diagnostics in outbreak response, not only for Ebola: a blueprint for a modular and robust field laboratory.

Roman Wölfel1, Kilian Stoecker, Erna Fleischmann, Brigitte Gramsamer, Matthias Wagner, Peter Molkenthin, Antonino Di Caro, Stephan Günther, Sofi Ibrahim, Gelimer H Genzel, Amanda J Ozin-Hofsäss, Pierre Formenty, Lothar Zöller.   

Abstract

We established a modular, rapidly deployable laboratory system that provides diagnostic support in resource-limited, remote areas. Developed as a quick response asset to unusual outbreaks of infectious diseases worldwide, several of these laboratories have been used as part of the World Health Organization response to the Ebola virus outbreaks by teams of the 'European Mobile Lab' project in West Africa since March 2014. Within three days from deployment, the first European mobile laboratory became operational at the Ebola Treatment Unit (ETU) in Guéckédou, southern Guinea. Deployment in close proximity to the ETU decreased the turnaround time to an average of 4 h instead of several days in many cases. Between March 2014 and May 2015, more than 5,800 samples were tested in this field laboratory. Further EMLab units were deployed to Nigeria, Liberia and Sierra Leone in the following months of the Ebola outbreak. The technical concept of the EMLab units served as a blueprint for other mobile Ebola laboratories which have been set up in Mali, Côte d'Ivoire, Sierra Leone and other countries in West Africa. Here, we describe design, capabilities and utility of this deployable laboratory system for use in response to disease outbreaks, epidemiological surveillance and patient management.

Entities:  

Keywords:  Ebola fever; Europe; Guinea; Liberia; Nigeria; Sierra Leone; laboratory; outbreaks; viral haemorrhagic fever

Mesh:

Year:  2015        PMID: 26559006     DOI: 10.2807/1560-7917.ES.2015.20.44.30055

Source DB:  PubMed          Journal:  Euro Surveill        ISSN: 1025-496X


  21 in total

Review 1.  Diagnosis of Ebola Virus Disease: Past, Present, and Future.

Authors:  M Jana Broadhurst; Tim J G Brooks; Nira R Pollock
Journal:  Clin Microbiol Rev       Date:  2016-10       Impact factor: 26.132

Review 2.  Case study: design and implementation of training for scientists deploying to Ebola diagnostic field laboratories in Sierra Leone: October 2014 to February 2016.

Authors:  Christopher H Logue; Suzanna M Lewis; Amber Lansley; Sara Fraser; Clare Shieber; Sonal Shah; Amanda Semper; Daniel Bailey; Jason Busuttil; Liz Evans; Miles W Carroll; Nigel J Silman; Tim Brooks; Jane A Shallcross
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2017-05-26       Impact factor: 6.237

3.  COVID-19 and Beyond: Safety and Design Considerations for the Development of a Mobile Biocontainment Laboratory.

Authors:  Martin Linster; Benson Ng; Viji Vijayan
Journal:  Appl Biosaf       Date:  2020-09-01

4.  Mobile High-Containment Biological Laboratories Deployment: Opportunities and Challenges in Expeditionary Deployments to Outbreak Response.

Authors:  Venkat Rao; Emily Bordelon
Journal:  Appl Biosaf       Date:  2019-03-01

5.  Rapid Bedside Inactivation of Ebola Virus for Safe Nucleic Acid Tests.

Authors:  Maiken Worsøe Rosenstierne; Helen Karlberg; Karoline Bragstad; Gunnel Lindegren; Malin Lundahl Stoltz; Cristiano Salata; Anne-Marte Bakken Kran; Susanne Gjeruldsen Dudman; Ali Mirazimi; Anders Fomsgaard
Journal:  J Clin Microbiol       Date:  2016-07-27       Impact factor: 5.948

6.  Ebola Laboratory Response at the Eternal Love Winning Africa Campus, Monrovia, Liberia, 2014-2015.

Authors:  Emmie de Wit; Kyle Rosenke; Robert J Fischer; Andrea Marzi; Joseph Prescott; Trenton Bushmaker; Neeltje van Doremalen; Shannon L Emery; Darryl Falzarano; Friederike Feldmann; Allison Groseth; Thomas Hoenen; Bonventure Juma; Kristin L McNally; Melvin Ochieng; Victor Omballa; Clayton O Onyango; Collins Owuor; Thomas Rowe; David Safronetz; Joshua Self; Brandi N Williamson; Galina Zemtsova; Allen Grolla; Gary Kobinger; Mark Rayfield; Ute Ströher; James E Strong; Sonja M Best; Hideki Ebihara; Kathryn C Zoon; Stuart T Nichol; Tolbert G Nyenswah; Fatorma K Bolay; Moses Massaquoi; Heinz Feldmann; Barry Fields
Journal:  J Infect Dis       Date:  2016-06-21       Impact factor: 5.226

7.  Analysis of Diagnostic Findings From the European Mobile Laboratory in Guéckédou, Guinea, March 2014 Through March 2015.

Authors:  Romy Kerber; Ralf Krumkamp; Boubacar Diallo; Anna Jaeger; Martin Rudolf; Simone Lanini; Joseph Akoi Bore; Fara Raymond Koundouno; Beate Becker-Ziaja; Erna Fleischmann; Kilian Stoecker; Silvia Meschi; Stéphane Mély; Edmund N C Newman; Fabrizio Carletti; Jasmine Portmann; Misa Korva; Svenja Wolff; Peter Molkenthin; Zoltan Kis; Anne Kelterbaum; Anne Bocquin; Thomas Strecker; Alexandra Fizet; Concetta Castilletti; Gordian Schudt; Lisa Ottowell; Andreas Kurth; Barry Atkinson; Marlis Badusche; Angela Cannas; Elisa Pallasch; Andrew Bosworth; Constanze Yue; Bernadett Pályi; Heinz Ellerbrok; Claudia Kohl; Lisa Oestereich; Christopher H Logue; Anja Lüdtke; Martin Richter; Didier Ngabo; Benny Borremans; Dirk Becker; Sophie Gryseels; Saïd Abdellati; Tine Vermoesen; Eeva Kuisma; Annette Kraus; Britta Liedigk; Piet Maes; Ruth Thom; Sophie Duraffour; Sandra Diederich; Julia Hinzmann; Babak Afrough; Johanna Repits; Marc Mertens; Inês Vitoriano; Amadou Bah; Andreas Sachse; Jan Peter Boettcher; Stephanie Wurr; Sabrina Bockholt; Andreas Nitsche; Tatjana Avšič Županc; Marc Strasser; Giuseppe Ippolito; Stephan Becker; Herve Raoul; Miles W Carroll; Hilde De Clerck; Michel Van Herp; Armand Sprecher; Lamine Koivogui; N'Faly Magassouba; Sakoba Keïta; Patrick Drury; Cèline Gurry; Pierre Formenty; Jürgen May; Martin Gabriel; Roman Wölfel; Stephan Günther; Antonino Di Caro
Journal:  J Infect Dis       Date:  2016-09-16       Impact factor: 5.226

8.  Establishing Ebola Virus Disease (EVD) diagnostics using GeneXpert technology at a mobile laboratory in Liberia: Impact on outbreak response, case management and laboratory systems strengthening.

Authors:  Philomena Raftery; Orla Condell; Christine Wasunna; Jonathan Kpaka; Ruth Zwizwai; Mahmood Nuha; Mosoka Fallah; Maxwell Freeman; Victoria Harris; Mark Miller; April Baller; Moses Massaquoi; Victoria Katawera; John Saindon; Philip Bemah; Esther Hamblion; Evelyn Castle; Desmond Williams; Alex Gasasira; Tolbert Nyenswah
Journal:  PLoS Negl Trop Dis       Date:  2018-01-05

9.  The East African Community (EAC) mobile laboratory networks in Kenya, Burundi, Tanzania, Rwanda, Uganda, and South Sudan-from project implementation to outbreak response against Dengue, Ebola, COVID-19, and epidemic-prone diseases.

Authors:  Muna Affara; Michael J Katende; Florian Gehre; Hakim Idris Lagu; Emmanuel Achol; Richard Karamagi; Neema Omari; Grace Ochido; Eric Kezakarayagwa; Francine Kabatesi; Anatole Nkeshimana; Abdi Roba; Millicent Nyakio Ndia; Mamo U Abudo; Alice Kabanda; Etienne Mpabuka; Emil Ivan Mwikarago; Philip Ezekiel Kutjok; Donald Duku Samson; Lul Lojok Deng; Nyambura Moremi; Maria Ezekiely Kelly; Peter Bernard Mtesigwa Mkama; Alex Magesa; Stephen Karabyo Balinandi; Godfrey Pimundu; Susan Ndidde Nabadda; Dewi Ismajani Puradiredja; Julia Hinzmann; Sophie Duraffour; Martin Gabriel; Gerd Ruge; Wibke Loag; Rogers Ayiko; Stanley Serser Sonoiya; Juergen May
Journal:  BMC Med       Date:  2021-07-09       Impact factor: 8.775

10.  Evaluation of RealStar Reverse Transcription-Polymerase Chain Reaction Kits for Filovirus Detection in the Laboratory and Field.

Authors:  Toni Rieger; Romy Kerber; Hussein El Halas; Elisa Pallasch; Sophie Duraffour; Stephan Günther; Stephan Ölschläger
Journal:  J Infect Dis       Date:  2016-08-21       Impact factor: 5.226

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