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Literature DB >> 26555169

Sugar Makes Fat by Talking to SCAP.

Abstract

Elevated blood glucose promotes lipogenesis via activating SREBP transcription factors. Tumors exhibit increased glucose uptake and lipogenesis, but the mechanisms controlling this are poorly understood. In this issue of Cancer Cell, Cheng and colleagues find that glucose activates SREBP by stabilizing SCAP, a central regulator of the SREBP pathway.

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Year: 2015 PMID： 26555169 PMCID： PMC4772404 DOI： 10.1016/j.ccell.2015.10.011

Source DB: PubMed Journal: Cancer Cell ISSN： 1535-6108 Impact factor: 31.743

10 in total

Review 1. Metabolism strikes back: metabolic flux regulates cell signaling.

Authors: Christian M Metallo; Matthew G Vander Heiden
Journal: Genes Dev Date: 2010-12-15 Impact factor: 11.361

2. Oncogenic PI3K and K-Ras stimulate de novo lipid synthesis through mTORC1 and SREBP.

Authors: S J H Ricoult; J L Yecies; I Ben-Sahra; B D Manning
Journal: Oncogene Date: 2015-06-01 Impact factor: 9.867

3. A key regulator of cholesterol homoeostasis, SREBP-2, can be targeted in prostate cancer cells with natural products.

Authors: James R Krycer; Lisa Phan; Andrew J Brown
Journal: Biochem J Date: 2012-09-01 Impact factor: 3.857

4. EGFR signaling through an Akt-SREBP-1-dependent, rapamycin-resistant pathway sensitizes glioblastomas to antilipogenic therapy.

Authors: Deliang Guo; Robert M Prins; Julie Dang; Daisuke Kuga; Akio Iwanami; Horacio Soto; Kelly Y Lin; Tiffany T Huang; David Akhavan; M Benjamin Hock; Shaojun Zhu; Ava A Kofman; Steve J Bensinger; William H Yong; Harry V Vinters; Steve Horvath; Andrew D Watson; John G Kuhn; H Ian Robins; Minesh P Mehta; Patrick Y Wen; Lisa M DeAngelis; Michael D Prados; Ingo K Mellinghoff; Timothy F Cloughesy; Paul S Mischel
Journal: Sci Signal Date: 2009-12-15 Impact factor: 8.192

Review 5. Expanding roles for SREBP in metabolism.

Authors: Wei Shao; Peter J Espenshade
Journal: Cell Metab Date: 2012-09-20 Impact factor: 27.287

Review 6. Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis.

Authors: Javier A Menendez; Ruth Lupu
Journal: Nat Rev Cancer Date: 2007-10 Impact factor: 60.716

7. Topology of SREBP cleavage-activating protein, a polytopic membrane protein with a sterol-sensing domain.

Authors: A Nohturfft; M S Brown; J L Goldstein
Journal: J Biol Chem Date: 1998-07-03 Impact factor: 5.157

8. Sterol regulatory element-binding protein (SREBP) cleavage regulates Golgi-to-endoplasmic reticulum recycling of SREBP cleavage-activating protein (SCAP).

Authors: Wei Shao; Peter J Espenshade
Journal: J Biol Chem Date: 2014-01-29 Impact factor: 5.157

9. Glucose-Mediated N-glycosylation of SCAP Is Essential for SREBP-1 Activation and Tumor Growth.

Authors: Chunming Cheng; Peng Ru; Feng Geng; Junfeng Liu; Ji Young Yoo; Xiaoning Wu; Xiang Cheng; Vanessa Euthine; Peng Hu; Jeffrey Yunhua Guo; Etienne Lefai; Balveen Kaur; Axel Nohturfft; Jianjie Ma; Arnab Chakravarti; Deliang Guo
Journal: Cancer Cell Date: 2015-11-09 Impact factor: 31.743

10. Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell survival and tumor growth.

Authors: Beatrice Griffiths; Caroline A Lewis; Karim Bensaad; Susana Ros; Qifeng Zhang; Emma C Ferber; Sofia Konisti; Barrie Peck; Heike Miess; Philip East; Michael Wakelam; Adrian L Harris; Almut Schulze
Journal: Cancer Metab Date: 2013-01-23

10 in total

5 in total

Sugar Makes Fat by Talking to SCAP.

Review 1. Metabolism strikes back: metabolic flux regulates cell signaling.

2. Oncogenic PI3K and K-Ras stimulate de novo lipid synthesis through mTORC1 and SREBP.

3. A key regulator of cholesterol homoeostasis, SREBP-2, can be targeted in prostate cancer cells with natural products.

4. EGFR signaling through an Akt-SREBP-1-dependent, rapamycin-resistant pathway sensitizes glioblastomas to antilipogenic therapy.

Review 5. Expanding roles for SREBP in metabolism.

Review 6. Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis.

7. Topology of SREBP cleavage-activating protein, a polytopic membrane protein with a sterol-sensing domain.

8. Sterol regulatory element-binding protein (SREBP) cleavage regulates Golgi-to-endoplasmic reticulum recycling of SREBP cleavage-activating protein (SCAP).

9. Glucose-Mediated N-glycosylation of SCAP Is Essential for SREBP-1 Activation and Tumor Growth.

10. Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell survival and tumor growth.

1. Analysis of SCAP N-glycosylation and Trafficking in Human Cells.

2. Ammonia stimulates SCAP/Insig dissociation and SREBP-1 activation to promote lipogenesis and tumour growth.

Review 3. Lipid metabolism reprogramming and its potential targets in cancer.

4. PGRMC Proteins Are Coming of Age: A Special Issue on the Role of PGRMC1 and PGRMC2 in Metabolism and Cancer Biology.

Review 5. Lipid Metabolism in Glioblastoma: From De Novo Synthesis to Storage.