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Literature DB >> 23000402

Expanding roles for SREBP in metabolism.

Abstract

Sterol regulatory element-binding protein (SREBP) transcription factors regulate cellular lipogenesis and lipid homeostasis. Recent studies reveal expanding roles for SREBPs with the description of new regulatory mechanisms, the identification of unexpected transcriptional targets, and the discovery of functions for SREBPs in type II diabetes, cancer, immunity, neuroprotection, and autophagy.

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Year: 2012 PMID： 23000402 PMCID： PMC3466394 DOI： 10.1016/j.cmet.2012.09.002

Source DB: PubMed Journal: Cell Metab ISSN： 1550-4131 Impact factor: 27.287

25 in total

Review 1. Protein sensors for membrane sterols.

Authors: Joseph L Goldstein; Russell A DeBose-Boyd; Michael S Brown
Journal: Cell Date: 2006-01-13 Impact factor: 41.582

2. Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP.

Authors: Amy K Walker; Fajun Yang; Karen Jiang; Jun-Yuan Ji; Jennifer L Watts; Aparna Purushotham; Olivier Boss; Michael L Hirsch; Scott Ribich; Jesse J Smith; Kristine Israelian; Christoph H Westphal; Joseph T Rodgers; Toshi Shioda; Sarah L Elson; Peter Mulligan; Hani Najafi-Shoushtari; Josh C Black; Jitendra K Thakur; Lisa C Kadyk; Johnathan R Whetstine; Raul Mostoslavsky; Pere Puigserver; Xiaoling Li; Nicholas J Dyson; Anne C Hart; Anders M Näär
Journal: Genes Dev Date: 2010-07-01 Impact factor: 11.361

Review 3. The Akt-SREBP nexus: cell signaling meets lipid metabolism.

Authors: James R Krycer; Laura J Sharpe; Winnie Luu; Andrew J Brown
Journal: Trends Endocrinol Metab Date: 2010-02-01 Impact factor: 12.015

4. Enzymatic reduction of oxysterols impairs LXR signaling in cultured cells and the livers of mice.

Authors: Wenling Chen; Guoxen Chen; Daphne L Head; David J Mangelsdorf; David W Russell
Journal: Cell Metab Date: 2007-01 Impact factor: 27.287

5. Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis.

Authors: Shijie Li; Michael S Brown; Joseph L Goldstein
Journal: Proc Natl Acad Sci U S A Date: 2010-02-01 Impact factor: 11.205

6. Role of NMDA receptor-dependent activation of SREBP1 in excitotoxic and ischemic neuronal injuries.

Authors: Changiz Taghibiglou; Henry G S Martin; Ted Weita Lai; Taesup Cho; Shiv Prasad; Luba Kojic; Jie Lu; Yitao Liu; Edmund Lo; Shu Zhang; Julia Z Z Wu; Yu Ping Li; Yan Hua Wen; Joon-Hyuk Imm; Max S Cynader; Yu Tian Wang
Journal: Nat Med Date: 2009-11-22 Impact factor: 53.440

7. Parasympathetic response in chick myocytes and mouse heart is controlled by SREBP.

Authors: Ho-Jin Park; Serban P Georgescu; Chuang Du; Christopher Madias; Mark J Aronovitz; C Michael Welzig; Bo Wang; Ulrike Begley; Yali Zhang; Robert O Blaustein; Richard D Patten; Richard H Karas; Herbert H Van Tol; Timothy F Osborne; Hitoshi Shimano; Ronglih Liao; Mark S Link; Jonas B Galper
Journal: J Clin Invest Date: 2008-01 Impact factor: 14.808

8. Unsaturated fatty acids inhibit proteasomal degradation of Insig-1 at a postubiquitination step.

Authors: Joon No Lee; Xiangyu Zhang; Jamison D Feramisco; Yi Gong; Jin Ye
Journal: J Biol Chem Date: 2008-10-03 Impact factor: 5.157

9. GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice.

Authors: Hélène L Kammoun; Hervé Chabanon; Isabelle Hainault; Serge Luquet; Christophe Magnan; Tatsuro Koike; Pascal Ferré; Fabienne Foufelle
Journal: J Clin Invest Date: 2009-04-13 Impact factor: 14.808

10. SREBPs suppress IRS-2-mediated insulin signalling in the liver.

Authors: Tomohiro Ide; Hitoshi Shimano; Naoya Yahagi; Takashi Matsuzaka; Masanori Nakakuki; Takashi Yamamoto; Yoshimi Nakagawa; Akimitsu Takahashi; Hiroaki Suzuki; Hirohito Sone; Hideo Toyoshima; Akiyoshi Fukamizu; Nobuhiro Yamada
Journal: Nat Cell Biol Date: 2004-03-14 Impact factor: 28.824

177 in total

Review 1. Exploring the emerging complexity in transcriptional regulation of energy homeostasis.

Authors: Adelheid Lempradl; J Andrew Pospisilik; Josef M Penninger
Journal: Nat Rev Genet Date: 2015-10-13 Impact factor: 53.242

2. Neuronal Activity-Induced Sterol Regulatory Element Binding Protein-1 (SREBP1) is Disrupted in Dysbindin-Null Mice-Potential Link to Cognitive Impairment in Schizophrenia.

Authors: Yong Chen; Sookhee Bang; Mary F McMullen; Hala Kazi; Konrad Talbot; Mei-Xuan Ho; Greg Carlson; Steven E Arnold; Wei-Yi Ong; Sangwon F Kim
Journal: Mol Neurobiol Date: 2016-02-12 Impact factor: 5.590

Expanding roles for SREBP in metabolism.

Review 1. Protein sensors for membrane sterols.

2. Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP.

Review 3. The Akt-SREBP nexus: cell signaling meets lipid metabolism.

4. Enzymatic reduction of oxysterols impairs LXR signaling in cultured cells and the livers of mice.

5. Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis.

6. Role of NMDA receptor-dependent activation of SREBP1 in excitotoxic and ischemic neuronal injuries.

7. Parasympathetic response in chick myocytes and mouse heart is controlled by SREBP.

8. Unsaturated fatty acids inhibit proteasomal degradation of Insig-1 at a postubiquitination step.

9. GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice.

10. SREBPs suppress IRS-2-mediated insulin signalling in the liver.

Review 1. Exploring the emerging complexity in transcriptional regulation of energy homeostasis.

2. Neuronal Activity-Induced Sterol Regulatory Element Binding Protein-1 (SREBP1) is Disrupted in Dysbindin-Null Mice-Potential Link to Cognitive Impairment in Schizophrenia.

Review 3. Phosphatidylinositol-3,4,5-triphosphate and cellular signaling: implications for obesity and diabetes.

4. Activated α2-macroglobulin binding to human prostate cancer cells triggers insulin-like responses.

Review 5. Lipids and cancer: Emerging roles in pathogenesis, diagnosis and therapeutic intervention.

6. The epigenetic drug 5-azacytidine interferes with cholesterol and lipid metabolism.

7. Sonic hedgehog signaling instigates high-fat diet-induced insulin resistance by targeting PPARγ stability.

Review 8. Map4k4 Signaling Nodes in Metabolic and Cardiovascular Diseases.

9. The possible antidiabetic effects of vitamin D receptors agonist in rat model of type 2 diabetes.

Review 10. The interplay between cell signalling and the mevalonate pathway in cancer.