Regis Souche1, Pietro Addeo2, Elie Oussoultzoglou2, Astrid Herrero3, Edoardo Rosso2, Francis Navarro3, Jean Michel Fabre3, Philippe Bachellier2. 1. Department of Surgery and Liver Transplantation, Hopital Saint Eloi-Hopitaux Universitaires de Montpellier, Université de Montpellier 1, 80, Avenue Augustin Fliche, 34295 Montpellier Cedex 5, France. Electronic address: fr-souche@chu-montpellier.fr. 2. Hepato-Pancreato-Biliary Surgery and Liver Transplantation, Pole des Pathologies Digestives, Hepatiques et de la Transplantation, Hopital de Hautepierre-Hopitaux Universitaires de Strasbourg, Université de Strasbourg, Strasbourg, France. 3. Department of Surgery and Liver Transplantation, Hopital Saint Eloi-Hopitaux Universitaires de Montpellier, Université de Montpellier 1, 80, Avenue Augustin Fliche, 34295 Montpellier Cedex 5, France.
Abstract
BACKGROUND: Recurrence after resection of intrahepatic cholangiocarcinoma (ICC) remains common. The present study sought to evaluate risk factors for recurrence and the results of repeat liver resection (RLR) for recurrent ICC. METHODS: Between 1997 and 2012, clinical data and outcomes of 125 consecutive patients undergoing liver resection for ICC were retrospectively analyzed. RESULTS: The rate of R0 resection was 89% (n = 110). Overall median survival was 35 months, and 1-, 3-, and 5-year actuarial survival rates were 80%, 48%, and 28%, respectively. Recurrence occurred in 76 patients (63.5%) and was intrahepatic only for 39 patients (51%). Tumor size greater than 5 cm was identified as an independent risk factor for recurrence (P ≤ .0001). RLR for recurrent ICC was feasible in 10 patients (25%) with a median survival after recurrence of 25 months (16 to 76). CONCLUSIONS: Tumor size more than 5 cm represents an independent risk factor for recurrence after resection of ICC. RLR in case of recurrent ICC, when feasible, is associated with longer overall survival.
BACKGROUND: Recurrence after resection of intrahepatic cholangiocarcinoma (ICC) remains common. The present study sought to evaluate risk factors for recurrence and the results of repeat liver resection (RLR) for recurrent ICC. METHODS: Between 1997 and 2012, clinical data and outcomes of 125 consecutive patients undergoing liver resection for ICC were retrospectively analyzed. RESULTS: The rate of R0 resection was 89% (n = 110). Overall median survival was 35 months, and 1-, 3-, and 5-year actuarial survival rates were 80%, 48%, and 28%, respectively. Recurrence occurred in 76 patients (63.5%) and was intrahepatic only for 39 patients (51%). Tumor size greater than 5 cm was identified as an independent risk factor for recurrence (P ≤ .0001). RLR for recurrent ICC was feasible in 10 patients (25%) with a median survival after recurrence of 25 months (16 to 76). CONCLUSIONS: Tumor size more than 5 cm represents an independent risk factor for recurrence after resection of ICC. RLR in case of recurrent ICC, when feasible, is associated with longer overall survival.
Authors: Pietro Addeo; Issam Jedidi; Andrea Locicero; François Faitot; Constantin Oncioiu; Alina Onea; Philippe Bachellier Journal: J Gastrointest Surg Date: 2018-11-26 Impact factor: 3.452
Authors: T Peter Kingham; Victoria G Aveson; Alice C Wei; Jason A Castellanos; Peter J Allen; Daniel P Nussbaum; Yinin Hu; Michael I D'Angelica Journal: Curr Probl Surg Date: 2020-06-30 Impact factor: 1.909