María I Gaitán1, Paulina Yañes2, Pascal Sati3, Carlos Romero2, Daniel S Reich3, Jorge Correale4. 1. Department of Neurology, Dr. Raúl Carrea Institute for Neurological Research, FLENI, Buenos Aires, Argentina migaitan@fleni.org.ar. 2. Department of Radiology, Dr. Raúl Carrea Institute for Neurological Research, FLENI, Buenos Aires, Argentina. 3. National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA. 4. Department of Neurology, Dr. Raúl Carrea Institute for Neurological Research, FLENI, Buenos Aires, Argentina.
Abstract
BACKGROUND: The infratentorial compartment is cardinal for multiple sclerosis (MS) diagnosis. T2-weighted (T2) and proton density-weighted (PD) magnetic resonance imaging (MRI) can visualize infratentorial lesions, but only suboptimally. OBJECTIVE: To combine PD and T2 for better lesion assessment. METHODS: T2 and PD from 35 cases were averaged to form "PT2" images. Two raters counted infratentorial lesions and qualitatively assessed their conspicuity. RESULTS: PT2 showed 244 infratentorial lesions, of which 94% and 74% were seen in PD and T2. PT2 received higher grades for image quality and lesion conspicuity (p < 0.001 for all comparisons). CONCLUSION: PT2 could improve our ability to diagnose and monitor MS.
BACKGROUND: The infratentorial compartment is cardinal for multiple sclerosis (MS) diagnosis. T2-weighted (T2) and proton density-weighted (PD) magnetic resonance imaging (MRI) can visualize infratentorial lesions, but only suboptimally. OBJECTIVE: To combine PD and T2 for better lesion assessment. METHODS:T2 and PD from 35 cases were averaged to form "PT2" images. Two raters counted infratentorial lesions and qualitatively assessed their conspicuity. RESULTS: PT2 showed 244 infratentorial lesions, of which 94% and 74% were seen in PD and T2. PT2 received higher grades for image quality and lesion conspicuity (p < 0.001 for all comparisons). CONCLUSION: PT2 could improve our ability to diagnose and monitor MS.
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