Literature DB >> 26552331

New bigenic mouse model increases the understanding of genetic synergism in the progression of prostate cancer.

David J Polman1, Douglas K Price1, William D Figg1.   

Abstract

A new bigenic mouse model, engineered with the overexpression of PSGR and the knockout of PTEN, has been used to study the relationship between 2 genes and disease progression. A study in Oncogene (Rodriguez et al.) has shown that these 2 genetic polymorphisms synergistically promote the development of prostate cancer.

Entities:  

Keywords:  NF-κB pathway; PIK3/Akt pathway; PSGR; PTEN; bigenic mouse model; disease progression; genetic synergism; prostate cancer

Year:  2015        PMID： 26552331      PMCID： PMC4847822          DOI： 10.1080/15384047.2015.1108498

Source DB:  PubMed          Journal:  Cancer Biol Ther        ISSN： 1538-4047            Impact factor:   4.742


  7 in total

1.  The PI3K-PKB/Akt pathway.

Authors:  Brian A Hemmings; David F Restuccia
Journal:  Cold Spring Harb Perspect Biol       Date:  2015-04-01       Impact factor: 10.005

2.  Cancer statistics, 2015.

Authors:  Rebecca L Siegel; Kimberly D Miller; Ahmedin Jemal
Journal:  CA Cancer J Clin       Date:  2015-01-05       Impact factor: 508.702

3.  PSGR, a novel prostate-specific gene with homology to a G protein-coupled receptor, is overexpressed in prostate cancer.

Authors:  L L Xu; B G Stackhouse; K Florence; W Zhang; N Shanmugam; I A Sesterhenn; Z Zou; V Srikantan; M Augustus; V Roschke; K Carter; D G McLeod; J W Moul; D Soppett; S Srivastava
Journal:  Cancer Res       Date:  2000-12-01       Impact factor: 12.701

4.  Loss of PTEN expression in paraffin-embedded primary prostate cancer correlates with high Gleason score and advanced stage.

Authors:  M E McMenamin; P Soung; S Perera; I Kaplan; M Loda; W R Sellers
Journal:  Cancer Res       Date:  1999-09-01       Impact factor: 12.701

5.  Nuclear factor-kappa B in rheumatoid synovium. Localization of p50 and p65.

Authors:  M L Handel; L B McMorrow; E M Gravallese
Journal:  Arthritis Rheum       Date:  1995-12

6.  Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN.

Authors:  V Stambolic; A Suzuki; J L de la Pompa; G M Brothers; C Mirtsos; T Sasaki; J Ruland; J M Penninger; D P Siderovski; T W Mak
Journal:  Cell       Date:  1998-10-02       Impact factor: 41.582

7.  PSGR promotes prostatic intraepithelial neoplasia and prostate cancer xenograft growth through NF-κB.

Authors:  M Rodriguez; W Luo; J Weng; L Zeng; Z Yi; S Siwko; M Liu
Journal:  Oncogenesis       Date:  2014-08-11       Impact factor: 7.485
  7 in total

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