Van T Nghiem1, Kalatu R Davies2, Wenyaw Chan3, Zuber D Mulla4, Scott B Cantor5. 1. Department of Health Services Research, The University of Texas MD Anderson Cancer Center, Houston; Center for Health Promotion and Prevention Research, The University of Texas School of Public Health, Houston; Department of Management, Policy and Community Health, The University of Texas School of Public Health, Houston. 2. Department of Health Services Research, The University of Texas MD Anderson Cancer Center, Houston. 3. Department of Biostatistics, The University of Texas School of Public Health, Houston. 4. Department of Obstetrics and Gynecology, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso; Department of Public Health, Graduate School of Biomedical Sciences, Texas Tech University Health Sciences Center, Lubbock. 5. Department of Health Services Research, The University of Texas MD Anderson Cancer Center, Houston. Electronic address: sbcantor@mdanderson.org.
Abstract
PURPOSE: We compared overall survival and influencing factors between Asian-American women as a whole and by subgroup with white women with cervical cancer. METHODS: Cervical cancer data were from the Surveillance, Epidemiology, and End Results registry; socioeconomic information was from the Area Health Resource File. We used standard tests to compare characteristics between groups; the Kaplan-Meier method with log-rank test to assess overall survival and compare it between groups; and Cox proportional hazards models to determine the effect of race and other covariates on overall survival (with and/or without age stratification). RESULTS: Being 3.3 years older than white women at diagnosis (P < .001), Asian-American women were more likely to be in a spousal relationship, had more progressive disease, and were better off socioeconomically. Women of Filipino, Japanese, and Korean origin had similar clinical characteristics compared to white women. Asian-American women had higher 36- and 60-month survival rates (P = .004 and P = .013, respectively), higher overall survival rates (P = .049), and longer overall survival durations after adjusting for age and other covariates (hazard ratio = 0.77, 95% confidence interval: 0.68-0.86). Overall survival differed across age strata between the two racial groups. With the exception of women of Japanese or Korean origin, Asian-American women grouped by geographic origin had better overall survival than white women. CONCLUSIONS: Although Asian-American women, except those of Japanese or Korean origin, had better overall survival than white women, their older age at cervical cancer diagnosis suggests that they have less access to screening programs.
PURPOSE: We compared overall survival and influencing factors between Asian-American women as a whole and by subgroup with white women with cervical cancer. METHODS:Cervical cancer data were from the Surveillance, Epidemiology, and End Results registry; socioeconomic information was from the Area Health Resource File. We used standard tests to compare characteristics between groups; the Kaplan-Meier method with log-rank test to assess overall survival and compare it between groups; and Cox proportional hazards models to determine the effect of race and other covariates on overall survival (with and/or without age stratification). RESULTS: Being 3.3 years older than white women at diagnosis (P < .001), Asian-American women were more likely to be in a spousal relationship, had more progressive disease, and were better off socioeconomically. Women of Filipino, Japanese, and Korean origin had similar clinical characteristics compared to white women. Asian-American women had higher 36- and 60-month survival rates (P = .004 and P = .013, respectively), higher overall survival rates (P = .049), and longer overall survival durations after adjusting for age and other covariates (hazard ratio = 0.77, 95% confidence interval: 0.68-0.86). Overall survival differed across age strata between the two racial groups. With the exception of women of Japanese or Korean origin, Asian-American women grouped by geographic origin had better overall survival than white women. CONCLUSIONS: Although Asian-American women, except those of Japanese or Korean origin, had better overall survival than white women, their older age at cervical cancer diagnosis suggests that they have less access to screening programs.
Authors: Steven E Waggoner; Kathleen M Darcy; Barbara Fuhrman; Groesbeck Parham; Joseph Lucci; Bradley J Monk; David H Moore Journal: Gynecol Oncol Date: 2006-07-03 Impact factor: 5.482
Authors: Leigh G Seamon; Rebecca L Tarrant; Steve T Fleming; Robin C Vanderpool; Sarah Pachtman; Iwona Podzielinski; Adam J Branscum; Jonathan M Feddock; Marcus E Randall; Christopher P Desimone Journal: Gynecol Oncol Date: 2011-10-02 Impact factor: 5.482
Authors: Katherine S Eggleston; Ann L Coker; Melanie Williams; Guillermo Tortolero-Luna; Jeanne B Martin; Susan R Tortolero Journal: J Womens Health (Larchmt) Date: 2006-10 Impact factor: 2.681
Authors: Stephanie A Robert; Indiana Strombom; Amy Trentham-Dietz; John M Hampton; Jane A McElroy; Polly A Newcomb; Patrick L Remington Journal: Epidemiology Date: 2004-07 Impact factor: 4.822
Authors: Jane R Montealegre; Renke Zhou; E Susan Amirian; Michele Follen; Michael E Scheurer Journal: Cancer Causes Control Date: 2013-08-11 Impact factor: 2.506
Authors: Frances B Maguire; Julianne J P Cooley; Cyllene R Morris; Arti Parikh-Patel; Vanessa A Kennedy; Theresa H M Keegan Journal: Cancer Causes Control Date: 2021-08-23 Impact factor: 2.506