Kuang-Chung Shih1, Anthony J Janckila2, Wei-Jei Lee3, Yu-Ching Chou4, Chun-Jui Huang5, Ching-Fai Kwok5, Low-Tone Ho6, Tsu-Yi Chao7. 1. Division of Endocrinology and Metabolism, Department of Medicine, Taipei-Veteran General Hospital, Taipei, Taiwan; Division of Endocrinology and Metabolism, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan. Electronic address: shihkc@totalbb.net.tw. 2. Special Hematology Laboratory, Department of Hematology, Veterans Affairs Medical Center, Louisville, KY, USA; Department of Microbiology and Immunology, University of Louisville, School of Medicine, Louisville, KY, USA. 3. Department of surgery, Ming-Sheng General Hospital, National Taiwan University, Tauoyan, Taiwan. 4. School of Public Health, National Defense Medical Center, Taipei, Taiwan. 5. Division of Endocrinology and Metabolism, Department of Medicine, Taipei-Veteran General Hospital, Taipei, Taiwan; Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan. 6. Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan. 7. Division of Hematology/Oncology, Shuang-Ho Hospital and Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Abstract
BACKGROUND: We determined effects of bariatric weight loss surgery on serum tartrate-resistant acid phosphatase 5a (TRACP 5a), inflammatory cytokines and glucose homeostasis in severely obese Chinese adults. METHODS: Severely obese adults undergoing bariatric surgery were recruited. Anthropometry, insulin resistance (IR), inflammatory markers and serum TRACP 5a were measured at baseline and 3, 6 and 12months postoperatively. RESULTS: Data of 93 patients, including 69 non-diabetic (non-DM group) and 24 diabetic (DM group), were analyzed. Anthropometry decreased significantly at 3months postoperatively in both groups; low-density lipoprotein cholesterol decreased obviously at 3, 6 and 12months in non-DM group, while improving significantly at 6 and 12months in DM group. Homeostasis model assessment for IR (HOMA-IR) improved significantly at 3, 6 and 12months in non-DM group and 12months in DM group. In DM group, C-reactive protein (CRP) decreased significantly at 3months postoperatively and inflammatory markers interleukin-6 (IL-6) and TRACP 5a improved at 6months postoperatively; in non-DM group, serum TRACP 5a decreased obviously at 12months postoperatively without significant changes in CRP and IL-6. CONCLUSION: Weight reduction by bariatric surgery decreases anthropometry, IR, lipids and inflammatory markers in severely obese Chinese adults.
BACKGROUND: We determined effects of bariatric weight loss surgery on serum tartrate-resistant acid phosphatase 5a (TRACP 5a), inflammatory cytokines and glucose homeostasis in severely obese Chinese adults. METHODS: Severely obese adults undergoing bariatric surgery were recruited. Anthropometry, insulin resistance (IR), inflammatory markers and serum TRACP 5a were measured at baseline and 3, 6 and 12months postoperatively. RESULTS: Data of 93 patients, including 69 non-diabetic (non-DM group) and 24 diabetic (DM group), were analyzed. Anthropometry decreased significantly at 3months postoperatively in both groups; low-density lipoprotein cholesterol decreased obviously at 3, 6 and 12months in non-DM group, while improving significantly at 6 and 12months in DM group. Homeostasis model assessment for IR (HOMA-IR) improved significantly at 3, 6 and 12months in non-DM group and 12months in DM group. In DM group, C-reactive protein (CRP) decreased significantly at 3months postoperatively and inflammatory markers interleukin-6 (IL-6) and TRACP 5a improved at 6months postoperatively; in non-DM group, serum TRACP 5a decreased obviously at 12months postoperatively without significant changes in CRP and IL-6. CONCLUSION: Weight reduction by bariatric surgery decreases anthropometry, IR, lipids and inflammatory markers in severely obese Chinese adults.
Authors: Ezequiel Lozano Chiappe; Maximiliano Martin; Andrea Iglesias Molli; Andrea Millan; Walter Tetzlaff; Eliana Botta; Florencia Ferraro; Maria S Sáez; Maria V Lorenzon Gonzalez; Laura Boero; Patricia Sorroche; Axel Beskow; Mercedes Gutierrez; Gloria Cerrone; Susana Gutt; Gustavo Frechtel; Fernando Brites Journal: Obes Surg Date: 2020-10-30 Impact factor: 4.129