Ting Yan1, Jia-Rui Yu1, Yun-Pei Zhang1, Tao Li2. 1. Department of Imaging, The Third Hospital of Ji Nan Shandong, China. 2. Department of Neurology, The Fourth Hospital of Ji Nan Shandong, China.
Abstract
OBJECTIVE: To investigate the correlation of white matter lesion (WML) and lacunar infarction (LI) with vascular cognitive impairment. To investigate the correlation of cognitive changes of vascular dementia (VD) patients with lacunar infarction (LI) and white matter lesion (WML). METHODS: The clinical data of 60 cases of VD patients were evaluated and analyzed by combining with imageological findings and cognitive function assessment. RESULTS: Multiple LI and WML were negatively correlated with both mini-mental state examination (MMSE) scale scores (r = -0.401, P = 0.036) and clock drawing test (CDT) scale scores (r = -0.482, P = 0.028); the LI number in occipital lobe was negatively correlated with MMSE scores (r = 0.338, P = 0.048), the LI number in temporal lobe was negatively correlated with CDT scores (r = -0.235, P = 0.047), and the LI number in frontal lobe was negatively correlated with MoCA scores (r = -0.450, P = 0.039). CONCLUSION: All of LI location and number as well as WML are independent influencing factors of cognitive impairment of VD patients.
OBJECTIVE: To investigate the correlation of white matter lesion (WML) and lacunar infarction (LI) with vascular cognitive impairment. To investigate the correlation of cognitive changes of vascular dementia (VD) patients with lacunar infarction (LI) and white matter lesion (WML). METHODS: The clinical data of 60 cases of VD patients were evaluated and analyzed by combining with imageological findings and cognitive function assessment. RESULTS: Multiple LI and WML were negatively correlated with both mini-mental state examination (MMSE) scale scores (r = -0.401, P = 0.036) and clock drawing test (CDT) scale scores (r = -0.482, P = 0.028); the LI number in occipital lobe was negatively correlated with MMSE scores (r = 0.338, P = 0.048), the LI number in temporal lobe was negatively correlated with CDT scores (r = -0.235, P = 0.047), and the LI number in frontal lobe was negatively correlated with MoCA scores (r = -0.450, P = 0.039). CONCLUSION: All of LI location and number as well as WML are independent influencing factors of cognitive impairment of VDpatients.
Entities:
Keywords:
White matter lesion; multiple lacunar infarction; vascular cognitive impairment
Authors: G-D Batty; Q Li; R Huxley; S Zoungas; B-A Taylor; B Neal; B de Galan; M Woodward; S-B Harrap; S Colagiuri; A Patel; J Chalmers Journal: Eur Psychiatry Date: 2011-10-02 Impact factor: 5.361
Authors: Robert Perneczky; Oren Tene; Johannes Attems; Panteleimon Giannakopoulos; M Arfan Ikram; Antonio Federico; Marie Sarazin; Lefkos T Middleton Journal: BMC Med Date: 2016-11-03 Impact factor: 8.775