OBJECTIVE: Examine the association of oral disease with future dementia/cognitive decline in a cohort of people with type 2 diabetes. METHODS: A total of 11,140 men and women aged 55-88 years at study induction with type 2 diabetes participated in a baseline medical examination when they reported the number of natural teeth and days of bleeding gums. Dementia and cognitive decline were ascertained periodically during a 5-year follow-up. RESULTS: Relative to the group with the greatest number of teeth (more than or equal to 22), having no teeth was associated with the highest risk of both dementia (hazard ratio; 95% confidence interval: 1.48; 1.24, 1.78) and cognitive decline (1.39; 1.21, 1.59). Number of days of bleeding gums was unrelated to these outcomes. CONCLUSIONS: Tooth loss was associated with an increased risk of both dementia and cognitive decline.
OBJECTIVE: Examine the association of oral disease with future dementia/cognitive decline in a cohort of people with type 2 diabetes. METHODS: A total of 11,140 men and women aged 55-88 years at study induction with type 2 diabetes participated in a baseline medical examination when they reported the number of natural teeth and days of bleeding gums. Dementia and cognitive decline were ascertained periodically during a 5-year follow-up. RESULTS: Relative to the group with the greatest number of teeth (more than or equal to 22), having no teeth was associated with the highest risk of both dementia (hazard ratio; 95% confidence interval: 1.48; 1.24, 1.78) and cognitive decline (1.39; 1.21, 1.59). Number of days of bleeding gums was unrelated to these outcomes. CONCLUSIONS: Tooth loss was associated with an increased risk of both dementia and cognitive decline.
Authors: Mark W J Strachan; Rebecca M Reynolds; Brian M Frier; Rory J Mitchell; Jacqueline F Price Journal: Br Med Bull Date: 2008-11-23 Impact factor: 4.291
Authors: Margaret Gatz; James A Mortimer; Laura Fratiglioni; Boo Johansson; Stig Berg; Chandra A Reynolds; Nancy L Pedersen Journal: Alzheimers Dement Date: 2006-04 Impact factor: 21.566
Authors: Supawadee Naorungroj; Victor J Schoenbach; Lisa Wruck; Thomas H Mosley; Rebecca F Gottesman; Alvaro Alonso; Gerardo Heiss; James Beck; Gary D Slade Journal: Community Dent Oral Epidemiol Date: 2014-11-03 Impact factor: 3.383
Authors: Supawadee Naorungroj; Victor J Schoenbach; James Beck; Thomas H Mosley; Rebecca F Gottesman; Alvaro Alonso; Gerardo Heiss; Gary D Slade Journal: J Am Dent Assoc Date: 2013-12 Impact factor: 3.634
Authors: B Daly; A Thompsell; J Sharpling; Y M Rooney; L Hillman; K L Wanyonyi; S White; J E Gallagher Journal: Br Dent J Date: 2017-12-01 Impact factor: 1.626
Authors: Huabin Luo; Chenxin Tan; Samrachana Adhikari; Brenda L Plassman; Angela R Kamer; Frank A Sloan; Mark D Schwartz; Xiang Qi; Bei Wu Journal: Curr Alzheimer Res Date: 2021 Impact factor: 3.498