Chen Zou1, Zipeng Lu1, Zhiqiang Zhang2, Liangtao Zhao3, Lei Tian3, Kuirong Jiang1, Yi Miao1. 1. Pancreas Institute of Nanjing Medical University Nanjing 210029, P. R. China ; Pancreas Center, The First Affiliated Hospital of Nanjing Medical University Nanjing 210029, P. R. China. 2. Pancreas Center, The First Affiliated Hospital of Nanjing Medical University Nanjing 210029, P. R. China. 3. Lab for Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University Nanjing 210029, P. R. China.
Abstract
OBJECTIVE: To identify potential risk factors associated with pancreatic infection in severe acute pancreatisis (SAP) patients, thus providing evidence for clinical prediction and treatment. METHODS: A total of 42 patients with SAP collected in our hospital from January 2013 to July 2014 were divided into two groups according to the presence or absence of pancreatic infection and retrospectively analyzed. Clinical characteristics and laboratory examine results of the two groups including age, sex, APACHE II score, serum amylase, serum calcium, blood glucose, ALT, AST, hyoxemia, serum albumin, serum creatinine and blood urea nitrogen were investigated for their relevance to pancreatic infection. RESULTS: The overall occurrence of secondary pancreatic infection of the 42 patients was 52.38%. A significantly positive correlation was revealed between the incidence rate of the secondary pancreatic infection and the factors including hyoxemia, blood creatinine and urea nitrogen in SAP patients (P < 0.05 or P < 0.01). Meanwhile, the level of serum albumin was negatively correlated with the rate of secondary infection in SAP patients (P < 0.01). The rest factors showed no significant correlation (P > 0.05). CONCLUSION: Hyoxemia, blood creatinine and urea nitrogen are potential factors leading to pancreatic infection in SAP patients, while an increase of serum albumin may reduce the incidence of infection.
OBJECTIVE: To identify potential risk factors associated with pancreatic infection in severe acute pancreatisis (SAP) patients, thus providing evidence for clinical prediction and treatment. METHODS: A total of 42 patients with SAP collected in our hospital from January 2013 to July 2014 were divided into two groups according to the presence or absence of pancreatic infection and retrospectively analyzed. Clinical characteristics and laboratory examine results of the two groups including age, sex, APACHE II score, serum amylase, serum calcium, blood glucose, ALT, AST, hyoxemia, serum albumin, serum creatinine and blood ureanitrogen were investigated for their relevance to pancreatic infection. RESULTS: The overall occurrence of secondary pancreatic infection of the 42 patients was 52.38%. A significantly positive correlation was revealed between the incidence rate of the secondary pancreatic infection and the factors including hyoxemia, blood creatinine and ureanitrogen in SAP patients (P < 0.05 or P < 0.01). Meanwhile, the level of serum albumin was negatively correlated with the rate of secondary infection in SAP patients (P < 0.01). The rest factors showed no significant correlation (P > 0.05). CONCLUSION: Hyoxemia, blood creatinine and ureanitrogen are potential factors leading to pancreatic infection in SAP patients, while an increase of serum albumin may reduce the incidence of infection.
Entities:
Keywords:
Severe acute pancreatisis; infection; risk factor
Authors: Michael Brand; Andrea Götz; Florian Zeman; Gundula Behrens; Michael Leitzmann; Tanja Brünnler; Okka W Hamer; Christian Stroszczynski; Peter Heiss Journal: AJR Am J Roentgenol Date: 2014-06 Impact factor: 3.959