Weiguo Xu1, Rong Cui2, Huapeng Yu3. 1. Department of Respiratory, Zhujiang Hospital, Southern Medical University Guangzhou, China ; Department of Respiratory, Mianyang Central Hospital Mianyang, China. 2. Department of Respiratory, Mianyang Central Hospital Mianyang, China. 3. Department of Respiratory, Zhujiang Hospital, Southern Medical University Guangzhou, China.
Abstract
BACKGROUND: SDF-1 G801A polymorphism is reported to correlate with cancer susceptibility. However, the association between SDF-1 G801A polymorphism and non-small cell lung cancer (NSCLC) risk in Chinese populations remains unknown. MATERIAL AND METHODS: A total of 408 NSCLC patients and 303 health controls included in this study. Restriction length fragment polymorphism (RFLP) analysis was used to assess the frequencies of SDF-1 G801A polymorphic variant. RESULTS: No significant association was found between SDF-1 G801A polymorphism and NSCLC risk (OR=1.268, 95% CI 0.811-2.583, P=0.361). Furthermore, SDF-1 G801A polymorphism was not correlated with histological type (P=0.697) and TNM stage (P=0.276). CONCLUSION: SDF-1 G801A polymorphism was not a risk factor for NSCLC in Chinese Han population.
BACKGROUND:SDF-1G801A polymorphism is reported to correlate with cancer susceptibility. However, the association between SDF-1G801A polymorphism and non-small cell lung cancer (NSCLC) risk in Chinese populations remains unknown. MATERIAL AND METHODS: A total of 408 NSCLCpatients and 303 health controls included in this study. Restriction length fragment polymorphism (RFLP) analysis was used to assess the frequencies of SDF-1G801A polymorphic variant. RESULTS: No significant association was found between SDF-1G801A polymorphism and NSCLC risk (OR=1.268, 95% CI 0.811-2.583, P=0.361). Furthermore, SDF-1G801A polymorphism was not correlated with histological type (P=0.697) and TNM stage (P=0.276). CONCLUSION:SDF-1G801A polymorphism was not a risk factor for NSCLC in Chinese Han population.
Authors: Łukasz Kruszyna; Margarita Lianeri; Błazej Rubis; Hanna Knuła; Maria Rybczyńska; Sylwia Grodecka-Gazdecka; Paweł P Jagodziński Journal: DNA Cell Biol Date: 2010-08 Impact factor: 3.311
Authors: Roderick J Phillips; Marie D Burdick; Marin Lutz; John A Belperio; Michael P Keane; Robert M Strieter Journal: Am J Respir Crit Care Med Date: 2003-03-05 Impact factor: 21.405