| Literature DB >> 15978329 |
Mahboobeh Razmkhah1, Abdul-Rasoul Talei, Mehrnoosh Doroudchi, Tahereh Khalili-Azad, Abbas Ghaderi.
Abstract
Stromal cell-Derived Factor-1 (SDF-1, CXCL12) is one the ELR- CXC angiogenic chemokines. It contributes to hematopoiesis and lymphocyte trafficking. SDF-1 and its exclusive receptor, CXCR4, are reported to play important roles in tumor growth, angiogenesis and metastasis of different types of tumors such as breast, lung, prostate and pancreatic cancers. SDF-1 gene polymorphism, known as SDF1-3'A, has been investigated in HIV-1 infection and the incidence of breast cancer. This investigation was aimed to study the frequency of SDF1-3'A mutation in Iranian women with breast cancer. Results showed that the frequency of AA and AG genotypes was higher among patients, while the frequency of GG genotype was lower compared to the controls. Thus AA and AG genotypes of SDF-1 may be considered as factors increasing the susceptibility of Iranian women to breast cancer.Entities:
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Year: 2004 PMID： 15978329 DOI： 10.1016/j.canlet.2004.10.039
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679