Dongping Huang1, Zhufeng Sun1, Jianwei Huang1, Zhaozai Shen2. 1. Department of General Surgery, People's Hospital of Putuo District Shanghai, 200060, China. 2. Department of Scientific Research, Tongji Hospital affiliated to Tongji University Shanghai, 200065, China.
Abstract
OBJECTIVE: To evaluate the therapeutic effects of nutritional support via different routes in elderly patients after surgery for gastrointestinal (GI) cancer. METHODS:105 patients with GI cancer were randomly divided into early enteral nutrition (EEN) group (n = 35), total parenteral nutrition (TPN) group (n = 35) and EN+PN group (n = 35). RESULTS: The nutrition status and immunity were significantly compromised in all patients, while the liver function was improved at 3 days after surgery as compared to those before surgery. At 7 days after surgery, they returned to preoperative level. The nutrition status was comparable among 3 groups at 3 and 7 days after surgery (P > 0.05). ALT, AST, ALP and GGT in TNP group were significantly higher than those in EEN group and EN+PN group (P < 0.05), whereas there was no significant difference in the liver function between EEN group and EN+PN group (P > 0.05). The CD3+ cells, CD4+ cells and CD4/CD8 in EEN group and EN+PN group were significantly higher than those in TPN group (P < 0.05), but significant difference was not observed between EEN group and EN+PN group (P > 0.05). The NK cells in EN+PN group were significantly higher than in TPN group (P < 0.01). The incidence of diarrhea in EEN group was significantly higher than in TPN group and EN+PN group (P < 0.05). CONCLUSION:EN+PN is superior to EEN alone and TPN alone in the old patients with GI cancer in reducing the postoperative complications, improving the immunity and decreasing the hospital stay.
RCT Entities:
OBJECTIVE: To evaluate the therapeutic effects of nutritional support via different routes in elderly patients after surgery for gastrointestinal (GI) cancer. METHODS: 105 patients with GI cancer were randomly divided into early enteral nutrition (EEN) group (n = 35), total parenteral nutrition (TPN) group (n = 35) and EN+PN group (n = 35). RESULTS: The nutrition status and immunity were significantly compromised in all patients, while the liver function was improved at 3 days after surgery as compared to those before surgery. At 7 days after surgery, they returned to preoperative level. The nutrition status was comparable among 3 groups at 3 and 7 days after surgery (P > 0.05). ALT, AST, ALP and GGT in TNP group were significantly higher than those in EEN group and EN+PN group (P < 0.05), whereas there was no significant difference in the liver function between EEN group and EN+PN group (P > 0.05). The CD3+ cells, CD4+ cells and CD4/CD8 in EEN group and EN+PN group were significantly higher than those in TPN group (P < 0.05), but significant difference was not observed between EEN group and EN+PN group (P > 0.05). The NK cells in EN+PN group were significantly higher than in TPN group (P < 0.01). The incidence of diarrhea in EEN group was significantly higher than in TPN group and EN+PN group (P < 0.05). CONCLUSION:EN+PN is superior to EEN alone and TPN alone in the old patients with GI cancer in reducing the postoperative complications, improving the immunity and decreasing the hospital stay.
Authors: Kristoffer Lassen; Cornelis H C Dejong; Olle Ljungqvist; Ken Fearon; Jens Andersen; Pascal Hannemann; Maarten F von Meyenfeldt; Jonatan Hausel; Jonas Nygren; Arthur Revhaug Journal: Dig Surg Date: 2005-11-16 Impact factor: 2.588
Authors: Ronald Chow; Eduardo Bruera; Jann Arends; Declan Walsh; Florian Strasser; Elisabeth Isenring; Egidio G Del Fabbro; Alex Molassiotis; Monica Krishnan; Leonard Chiu; Nicholas Chiu; Stephanie Chan; Tian Yi Tang; Henry Lam; Michael Lock; Carlo DeAngelis Journal: Support Care Cancer Date: 2019-12-07 Impact factor: 3.603