| Literature DB >> 26550276 |
Caipeng Lei1, Weiguo Zhang1, Junli Fan1, Bin Qiao1, Qiang Chen1, Qin Liu1, Chunling Zhao2.
Abstract
Murine double minute 2 (MDM2) has suggested to play an important role in esophageal cancer. The association between MDM2 T309G polymorphism and esophageal cancer risk was inconclusive. To clarify the possible association, we conducted a meta-analysis. We searched in the PubMed, Embase, and Wanfang databases. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association. A total of 6 studies with 4909 cases and controls were included based on the search criteria. The MDM2 T309G polymorphism was associated with a significantly decreased risk of esophageal cancer (OR=0.88; 95% CI, 0.81-0.96; I(2)=22%). When stratified by type of race, a significantly decreased esophageal cancer risk were observed in Asians (OR=0.85; 95% CI, 0.78-0.93; I(2)=0%). In conclusion, this meta-analysis suggested that MDM2 T309G polymorphism was associated with a significantly decreased risk of esophageal cancer.Entities:
Keywords: Esophageal cancer; MDM2; meta-analysis; polymorphism
Year: 2015 PMID： 26550276 PMCID： PMC4612961
Source DB: PubMed Journal: Int J Clin Exp Med ISSN： 1940-5901