The association between DVWA polymorphisms and osteoarthritis susceptibility: a genetic meta-analysis.

It has been reported that the double von Willebrandfactor domain A (DVWA) gene polymorphisms may be associated with osteoarthritis (OA) risk. However, some studies yielded conflicting results. Therefore, we conducted a comprehensive meta-analysis to identify the association of DVWA gene polymorphisms and the susceptibility to OA. We conducted a systematic search in PubMed, Embase (Ovid), China National Knowledge Internet (CNKI) and Wangfang databases up to May 15, 2015. Odds ratio (OR) and 95% confidence interval (CI) were used to pool the effect size. Statistical analyses were performed with STATA 11.0 software. In total, 11 studies from five articles with 13,579 subjectswere included in this meta-analysis. The overall results indicated that there was a significant association between DVWA rs7639618 polymorphism and OA susceptibility observed in dominant and co-dominant models. In the subgroup analysis, we found that DVWA gene rs7639618 and rs11718863 polymorphism was associated with OA risk in Asians (GG+GA vs. AA: OR=1.34, P<0.001; G vs. A: OR=1.29, P=0.019). Furthermore, for rs7639618, the dominant (GG+GA) and heterozygote (GA) may strongly increase the knee OA susceptibility (GG+GA vs. AA: OR=1.27, P<0.001), especially in Asians. In addition, as for rs11718863, a trend of increased knee OA risk was found in Asians (TT+TA vs. AA: OR=1.54, P<0.001). In conclusion, the meta-analysis results suggested that DVWArs7639618 and rs11718863 polymorphisms may increase the risk of knee OA susceptibility in Asians, but not in Caucasians. However, no significant association between SNP rs7639618 and rs11718863 and hip OA risk was identified.