| Literature DB >> 26548986 |
Diana A Zaleta-Pinet1, Ian P Holland2, Mauricio Muñoz-Ochoa3, J Ivan Murillo-Alvarez4, Jennette A Sakoff5, Ian A van Altena6, Adam McCluskey7.
Abstract
BACKGROUND: The current investigation sought to explore the nature of the secondary metabolites in the algae, Laurencia pacifica. <br> RESULTS: This report details the first isolation of the sesquiterpenes isoaplysin (1), isolaurenisol (2), debromoisolaurinterol (3), debromoaplysinol (4), laur-11-en-10-ol (5), 10α-hydroxyldebromoepiaplysin (6), and the previously unknown 10-bromo-3,7,11,11-tetramethylspiro[5.5]undeca-1,7-dien-3-ol (7) from the algae, Laurencia pacifica. Isoaplysin (1) and debromoaplysinol (4) showed promising levels of growth inhibition against a panel cancer-derived cell lines of colon (HT29), glioblastoma (U87, SJ-G2), breast (MCF-7), ovarian (A2780), lung (H460), skin (A431), prostate (Du145), neuroblastoma (BE2-C), pancreas (MIA), murine glioblastoma (SMA) origin with average GI50 values of 23 and 14 μM. <br> CONCLUSIONS: Isoaplysin (1) and debromoaplysinol (4) were up to fourfold more potent in cancer-derived cell populations than in non-tumor-derived normal cells (MCF10A). These analogues are promising candidates for anticancer drug development. Graphical Abstract ᅟ.Entities:
Keywords: Algae; Anti-cancer; Cytotoxicity; Laurencia pacifica; Sesquiterpenes
Year: 2014 PMID： 26548986 PMCID： PMC4610114 DOI： 10.1186/s13588-014-0008-8
Source DB: PubMed Journal: Org Med Chem Lett ISSN： 2191-2858