| Literature DB >> 26545888 |
Lobna Ezzi1, Imen Belhadj Salah2, Zohra Haouas2, Amina Sakly2, Intissar Grissa2, Sana Chakroun2, Emna Kerkeni2, Mohsen Hassine3, Meriem Mehdi2, Hassen Ben Cheikh2.
Abstract
This study aims to investigate the effects of chlorpyrifos's sub-acute exposure on male rats. Two groups with six animals each were orally treated, respectively, with 3.1 mg/kg b w and 6.2 mg/kg b w of chlorpyrifos during 4 weeks. The genotoxic effect of chlopyrifos was investigated using the comet assay and the micronucleus test. Some hematological and liver's histopathological changes were also evaluated. Results revealed that chlorpyrifos induced histopathological alterations in liver parenchyma. The lymphoid infiltration observed in liver sections and the increase in white blood cells parameter are signs of inflammation. A significant increase in the platelet' count and in polychromatic erythrocytes/normochromatic erythrocytes (PCE/NCE) ratio was observed in chlorpyrifos-treated groups which could be due to the stimulatory effect of chlorpyrifos on cell formation in the bone marrow at lower doses. In addition, the increase of bone marrow micronucleus percentage and the comet tail length revealed a genotoxic potential of chlorpyrifos in vivo.Entities:
Keywords: Chlorpyrifos; Genotoxicity; Hematological parameters; Liver; Organophosphate
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Year: 2015 PMID： 26545888 DOI： 10.1007/s11356-015-5722-x
Source DB: PubMed Journal: Environ Sci Pollut Res Int ISSN： 0944-1344 Impact factor: 4.223