Qing-Fei Zhao1, Lan Tan2, Hui-Fu Wang3, Teng Jiang3, Meng-Shan Tan1, Lin Tan4, Wei Xu1, Jie-Qiong Li1, Jun Wang1, Te-Jen Lai5, Jin-Tai Yu6. 1. Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, China. 2. Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, China; Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, Qingdao, China; College of Medicine and Pharmaceutics, Ocean University of China, Qingdao, China. Electronic address: dr.tanlan@163.com. 3. Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, Qingdao, China. 4. College of Medicine and Pharmaceutics, Ocean University of China, Qingdao, China. 5. Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan; Department of Psychiatry, Chung Shan Medical University Hospital, Taichung, Taiwan. 6. Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, China; Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, Qingdao, China; College of Medicine and Pharmaceutics, Ocean University of China, Qingdao, China; Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA. Electronic address: jintai.yu@ucsf.edu.
Abstract
BACKGROUND: Neuropsychiatric symptoms (NPS) are being increasingly recognized as common serious problems in Alzheimer's disease (AD). However, published data on the prevalence of NPS in persons with AD are conflicting. This meta-analysis aimed to estimate the prevalence of NPS in persons with AD. METHODS: Studies published from 1964 to September 30, 2014, were identified from PubMed and Embase database, reference lists and conference abstracts. We calculated prevalence rates and conducted meta-regression analysis with random-effects model, according to study characteristics, population demographics or condition information. RESULTS: We identified 48 eligible articles, which provided data for 12 NPS reported in Neuropsychiatric Inventory (NPI). The most frequent NPS was apathy, with an overall prevalence of 49% (95% CI 41-57%), followed by depression, aggression, anxiety and sleep disorder, the pooled prevalence estimates of which were 42% (95% CI 37-46%), 40% (95% CI 33-46%), 39% (95% CI 32-46%) and 39% (95% CI 30-47%), respectively. The less prevalent NPS were irritability (36%, 31-41%), appetite disorder (34%, 27-41%), aberrant motor behavior (32%, 25-38%), delusion (31%, 27-35%), disinhibition (17%, 12-21%) and hallucination (16%, 13-18%). Least common was euphoria, with an overall prevalence of 7% (95% CI 5-9%). LIMITATIONS: Several aspects, such as the quality of included studies were not always optimal and there was significant heterogeneity of prevalence estimate across studies. CONCLUSIONS: NPS were observed to be highly prevalent in AD patients. Disease duration, age, education level, population origin and the severity of cognitive impairment had influence on the prevalence of some NPS.
BACKGROUND:Neuropsychiatric symptoms (NPS) are being increasingly recognized as common serious problems in Alzheimer's disease (AD). However, published data on the prevalence of NPS in persons with AD are conflicting. This meta-analysis aimed to estimate the prevalence of NPS in persons with AD. METHODS: Studies published from 1964 to September 30, 2014, were identified from PubMed and Embase database, reference lists and conference abstracts. We calculated prevalence rates and conducted meta-regression analysis with random-effects model, according to study characteristics, population demographics or condition information. RESULTS: We identified 48 eligible articles, which provided data for 12 NPS reported in Neuropsychiatric Inventory (NPI). The most frequent NPS was apathy, with an overall prevalence of 49% (95% CI 41-57%), followed by depression, aggression, anxiety and sleep disorder, the pooled prevalence estimates of which were 42% (95% CI 37-46%), 40% (95% CI 33-46%), 39% (95% CI 32-46%) and 39% (95% CI 30-47%), respectively. The less prevalent NPS were irritability (36%, 31-41%), appetite disorder (34%, 27-41%), aberrant motor behavior (32%, 25-38%), delusion (31%, 27-35%), disinhibition (17%, 12-21%) and hallucination (16%, 13-18%). Least common was euphoria, with an overall prevalence of 7% (95% CI 5-9%). LIMITATIONS: Several aspects, such as the quality of included studies were not always optimal and there was significant heterogeneity of prevalence estimate across studies. CONCLUSIONS:NPS were observed to be highly prevalent in ADpatients. Disease duration, age, education level, population origin and the severity of cognitive impairment had influence on the prevalence of some NPS.
Authors: Mario F Mendez; Sylvia S Fong; Mark M Ashla; Elvira E Jimenez; Andrew R Carr Journal: J Neuropsychiatry Clin Neurosci Date: 2018-04-06 Impact factor: 2.198
Authors: Efstratios Karavasilis; Theodore P Parthimos; John D Papatriantafyllou; Sokratis G Papageorgiou; George Kapsas; Andrew C Papanicolaou; Ioannis Seimenis Journal: J Neurol Date: 2017-08-30 Impact factor: 4.849