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Literature DB >> 26540021

Injectable Self-Healing Glucose-Responsive Hydrogels with pH-Regulated Mechanical Properties.

Volkan Yesilyurt^1,2, Matthew J Webber^1,2, Eric A Appel¹, Colin Godwin³, Robert Langer^1,2,3,4, Daniel G Anderson^1,2,3,4.

Abstract

Dynamically restructuring pH-responsive hydrogels are synthesized, employing dynamic covalent chemistry between phenylboronic acid and cis-diol modified poly(ethylene glycol) macromonomers. These gels display shear-thinning behavior, followed by a rapid structural recovery (self-healing). Size-dependent in vitro controlled and glucose-responsive release of proteins from the hydrogel network, as well as the biocompatibility of the gels, are evaluated both in vitro and in vivo.

Entities: CellLine Chemical Disease Gene Species

Keywords: boronic acids; dynamic covalent bonds; hydrogels; rheology; self-healing

Mesh：

Substances：

Year: 2015 PMID： 26540021 PMCID： PMC4825176 DOI： 10.1002/adma.201502902

Source DB: PubMed Journal: Adv Mater ISSN： 0935-9648 Impact factor: 30.849

18 in total

1. Formation of single-chain polymer nanoparticles in water through host-guest interactions.

Authors: Eric A Appel; Joseph Dyson; Jesús del Barrio; Zarah Walsh; Oren A Scherman
Journal: Angew Chem Int Ed Engl Date: 2012-03-15 Impact factor: 15.336

Review 2. 25th anniversary article: Engineering hydrogels for biofabrication.

Authors: Jos Malda; Jetze Visser; Ferry P Melchels; Tomasz Jüngst; Wim E Hennink; Wouter J A Dhert; Jürgen Groll; Dietmar W Hutmacher
Journal: Adv Mater Date: 2013-08-23 Impact factor: 30.849

3. Conductive, physiologically responsive hydrogels.

Authors: Jin-Oh You; Debra T Auguste
Journal: Langmuir Date: 2010-04-06 Impact factor: 3.882

4. Dynamic-covalent macromolecular stars with boronic ester linkages.

Authors: Abhijeet P Bapat; Debashish Roy; Jacob G Ray; Daniel A Savin; Brent S Sumerlin
Journal: J Am Chem Soc Date: 2011-11-21 Impact factor: 15.419

5. pH responsive self-healing hydrogels formed by boronate-catechol complexation.

Authors: Lihong He; Dominic E Fullenkamp; José G Rivera; Phillip B Messersmith
Journal: Chem Commun (Camb) Date: 2011-06-01 Impact factor: 6.222

6. Tunable supramolecular hydrogel for in situ encapsulation and sustained release of bioactive lysozyme.

Authors: Dong Ma; Li-Ming Zhang; Xi Xie; Tao Liu; Min-Qiang Xie
Journal: J Colloid Interface Sci Date: 2011-04-18 Impact factor: 8.128

7. Supramolecular cross-linked networks via host-guest complexation with cucurbit[8]uril.

Authors: Eric A Appel; Frank Biedermann; Urs Rauwald; Samuel T Jones; Jameel M Zayed; Oren A Scherman
Journal: J Am Chem Soc Date: 2010-10-13 Impact factor: 15.419

8. Triply-responsive boronic acid block copolymers: solution self-assembly induced by changes in temperature, pH, or sugar concentration.

Authors: Debashish Roy; Jennifer N Cambre; Brent S Sumerlin
Journal: Chem Commun (Camb) Date: 2009-02-26 Impact factor: 6.222

9. Glucose-responsive polymer bearing a novel phenylborate derivative as a glucose-sensing moiety operating at physiological pH conditions.

Authors: Akira Matsumoto; Syuhei Ikeda; Atsushi Harada; Kazunori Kataoka
Journal: Biomacromolecules Date: 2003 Sep-Oct Impact factor: 6.988

10. Biophysically defined and cytocompatible covalently adaptable networks as viscoelastic 3D cell culture systems.

Authors: Daniel D McKinnon; Dylan W Domaille; Jennifer N Cha; Kristi S Anseth
Journal: Adv Mater Date: 2013-10-11 Impact factor: 30.849

46 in total

Review 1. Glucose-Responsive Insulin and Delivery Systems: Innovation and Translation.

Authors: Jinqiang Wang; Zejun Wang; Jicheng Yu; Anna R Kahkoska; John B Buse; Zhen Gu
Journal: Adv Mater Date: 2019-08-18 Impact factor: 30.849

2. Designing hydrogels for controlled drug delivery.

Authors: Jianyu Li; David J Mooney
Journal: Nat Rev Mater Date: 2016-10-18 Impact factor: 66.308

3. Sequential Targeting in Crosslinking Nanotheranostics for Tackling the Multibarriers of Brain Tumors.

Authors: Hao Wu; Hongwei Lu; Wenwu Xiao; Jinfan Yang; Hongxu Du; Yingbin Shen; Haijing Qu; Bei Jia; Suman K Manna; Mythili Ramachandran; Xiangdong Xue; Zhao Ma; Xiaobao Xu; Zhongling Wang; Yixuan He; Kit S Lam; Robert J Zawadzki; Yuanpei Li; Tzu-Yin Lin
Journal: Adv Mater Date: 2020-02-20 Impact factor: 30.849

Injectable Self-Healing Glucose-Responsive Hydrogels with pH-Regulated Mechanical Properties.

1. Formation of single-chain polymer nanoparticles in water through host-guest interactions.

Review 2. 25th anniversary article: Engineering hydrogels for biofabrication.

3. Conductive, physiologically responsive hydrogels.

4. Dynamic-covalent macromolecular stars with boronic ester linkages.

5. pH responsive self-healing hydrogels formed by boronate-catechol complexation.

6. Tunable supramolecular hydrogel for in situ encapsulation and sustained release of bioactive lysozyme.

7. Supramolecular cross-linked networks via host-guest complexation with cucurbit[8]uril.

8. Triply-responsive boronic acid block copolymers: solution self-assembly induced by changes in temperature, pH, or sugar concentration.

9. Glucose-responsive polymer bearing a novel phenylborate derivative as a glucose-sensing moiety operating at physiological pH conditions.

10. Biophysically defined and cytocompatible covalently adaptable networks as viscoelastic 3D cell culture systems.

Review 1. Glucose-Responsive Insulin and Delivery Systems: Innovation and Translation.

2. Designing hydrogels for controlled drug delivery.

3. Sequential Targeting in Crosslinking Nanotheranostics for Tackling the Multibarriers of Brain Tumors.

4. Tunable Hydrogels: Introduction to the World of Smart Materials for Biomedical Applications.

Review 5. Development of glucose-responsive 'smart' insulin systems.

6. Chemical Approaches to Dynamically Modulate the Properties of Synthetic Matrices.

7. Glucose-Responsive Trehalose Hydrogel for Insulin Stabilization and Delivery.

8. Injectable and Glucose-Responsive Hydrogels Based on Boronic Acid-Glucose Complexation.

Review 9. Physical and Chemical Factors Influencing the Printability of Hydrogel-based Extrusion Bioinks.

10. Controlling the Release of Small, Bioactive Proteins via Dual Mechanisms with Therapeutic Potential.