Literature DB >> 26537495

A metabonomic investigation on the biochemical perturbation in post-stroke patients with depressive disorder (PSD).

Xinghua Ding1,2, Ruoxu Liu1,3, Wenkai Li2, Hengjia Ni4, Yong Liu1, Dandan Wu1, Shuguang Yang5, Jing Liu6, Bo Xiao7,8, Shaojun Liu9.   

Abstract

A metabonomics study based on GC/MS and multivariate statistical analysis was performed involving 28 post stroke depressed (PSD) patients, 27 post-stroke non-depressed (PSND) patients and 33 healthy subjects to investigate the biochemical perturbation in their plasma samples. The outcome of this study showed that there was distinctive metabolic profile for PSD patients. Seven sentinel metabolites showed marked perturbations in PSD patients' blood. The introduction of metabonomics approach may provide a novel metabonomic insight about PSD and the sentinel metabolites for classifying PSD.

Entities:  

Keywords:  GC/MS; Metabonomics; Post-stroke depression; Stroke rehabilitation

Mesh：

Year:  2015        PMID： 26537495     DOI： 10.1007/s11011-015-9748-z

Source DB:  PubMed          Journal:  Metab Brain Dis        ISSN： 0885-7490            Impact factor:   3.584


  49 in total

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8.  Post-stroke depression: relationships to functional impairment, coping strategies, and rehabilitation outcome.

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9.  Post-stroke depression: research methodology of a large multicentre observational study (DESTRO).

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  10 in total

1.  Peripheral blood and urine metabolites and biological functions in post-stroke depression.

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2.  Metabolomics facilitates the discovery of metabolic biomarkers and pathways for ischemic stroke: a systematic review.

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3.  Hippocampal metabolic differences implicate distinctions between physical and psychological stress in four rat models of depression.

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4.  Metabolomics variable selection and classification in the presence of observations below the detection limit using an extension of ERp.

Authors:  Mari van Reenen; Johan A Westerhuis; Carolus J Reinecke; J Hendrik Venter
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5.  Effects of Shu Gan Jian Pi formula on rats with carbon tetrachloride‑induced liver fibrosis using serum metabonomics based on gas chromatography‑time of flight mass spectrometry.

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6.  Biomarker for Ischemic Stroke Using Metabolome: A Clinician Perspective.

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Review 7.  Metabolome Changes in Cerebral Ischemia.

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Journal:  Cells       Date:  2020-07-07       Impact factor: 6.600

8.  Plasma lipidomic profiling identifies a novel complex lipid signature associated with ischemic stroke in chronic kidney disease.

Authors:  Farsad Afshinnia; Adil Jadoon; Thekkelnaycke M Rajendiran; Tanu Soni; Jaeman Byun; George Michailidis; Subramaniam Pennathur
Journal:  J Transl Sci       Date:  2020-04-20

9.  Analysis of Metabolite and Lipid Association Networks Reveals Molecular Mechanisms Associated with 3-Month Mortality and Poor Functional Outcomes in Patients with Acute Ischemic Stroke after Thrombolytic Treatment with Recombinant Tissue Plasminogen Activator.

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Review 10.  Does urinary metabolite signature act as a biomarker of post-stroke depression?

Authors:  Wa Cai; Xia-Fei Wang; Xi-Fang Wei; Jing-Ruo Zhang; Chen Hu; Wen Ma; Wei-Dong Shen
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  10 in total

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