Literature DB >> 26531737

Low-intensity pulsed ultrasound treatment as an alternative to vascular bone graft surgery for a 5-year-long ulnar non-union in a patient with haemochromatosis.

Sebastian Daniel Povlsen1, Bo Povlsen2.   

Abstract

We present the case of a 75-year-old woman with haemochromatosis who developed a 5-year-long right ulnar non-union after a shortening osteotomy to correct a malunited Colles' fracture. Standard surgical treatment for ulnar non-unions was attempted on 19 March 2008 and again on 20 April 2009, but the non-union persisted on 8 May 2012, as confirmed by CT scan. Vascular bone grafting and refixation was then considered, but the patient declined this extensive operation, instead choosing to try non-invasive low-intensity pulsed ultrasound treatment with an Exogen device. Just 4 months later, complete union as confirmed by CT scan was achieved. This is the first case demonstrating the efficacy of ultrasound treatment for long-standing non-unions resistant to surgery in patients with haemochromatosis, a disorder where iron deposition can provide suboptimal circumstances for bone healing. Our finding suggests that low-intensity pulsed ultrasound devices could be used as a first-line treatment for stable non-unions instead of revision surgery. 2015 BMJ Publishing Group Ltd.

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Year:  2015        PMID: 26531737      PMCID: PMC4654171          DOI: 10.1136/bcr-2015-211950

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN: 1757-790X


  14 in total

1.  Bone status in a mouse model of genetic hemochromatosis.

Authors:  P Guggenbuhl; P Fergelot; M Doyard; H Libouban; M-P Roth; Y Gallois; G Chalès; O Loréal; D Chappard
Journal:  Osteoporos Int       Date:  2010-10-26       Impact factor: 4.507

2.  Low intensity pulsed ultrasound stimulates osteogenic activity of human periosteal cells.

Authors:  K S Leung; W H Cheung; C Zhang; K M Lee; H K Lo
Journal:  Clin Orthop Relat Res       Date:  2004-01       Impact factor: 4.176

3.  Early gene response to low-intensity pulsed ultrasound in rat osteoblastic cells.

Authors:  Kotaro Sena; Robert M Leven; Khurram Mazhar; Dale R Sumner; Amarjit S Virdi
Journal:  Ultrasound Med Biol       Date:  2005-05       Impact factor: 2.998

Review 4.  Vascularised bone grafts for the management of non-union.

Authors:  Panayotis N Soucacos; Zoe Dailiana; Alexandros E Beris; Elizabeth O Johnson
Journal:  Injury       Date:  2006-04-11       Impact factor: 2.586

5.  Low-intensity pulsed ultrasound accelerates rat femoral fracture healing by acting on the various cellular reactions in the fracture callus.

Authors:  Y Azuma; M Ito; Y Harada; H Takagi; T Ohta; S Jingushi
Journal:  J Bone Miner Res       Date:  2001-04       Impact factor: 6.741

6.  Effects of iron overload on bone remodeling in pigs.

Authors:  M C de Vernejoul; A Pointillart; C C Golenzer; C Morieux; J Bielakoff; D Modrowski; L Miravet
Journal:  Am J Pathol       Date:  1984-09       Impact factor: 4.307

7.  Low-intensity pulsed ultrasound in the treatment of nonunions.

Authors:  P A Nolte; A van der Krans; P Patka; I M Janssen; J P Ryaby; G H Albers
Journal:  J Trauma       Date:  2001-10

8.  Effects of low-intensity pulsed ultrasound, dexamethasone/TGF-beta1 and/or BMP-2 on the transcriptional expression of genes in human mesenchymal stem cells: chondrogenic vs. osteogenic differentiation.

Authors:  Chien-Hung Lai; Shih-Ching Chen; Li-Hsuan Chiu; Charng-Bin Yang; Yu-Hui Tsai; Chun S Zuo; Walter Hong-Shong Chang; Wen-Fu Lai
Journal:  Ultrasound Med Biol       Date:  2010-06       Impact factor: 2.998

9.  Association between iron overload and osteoporosis in patients with hereditary hemochromatosis.

Authors:  L Valenti; M Varenna; A L Fracanzani; V Rossi; S Fargion; L Sinigaglia
Journal:  Osteoporos Int       Date:  2008-07-26       Impact factor: 4.507

10.  Excess iron inhibits osteoblast metabolism.

Authors:  Kanako Yamasaki; Hiromi Hagiwara
Journal:  Toxicol Lett       Date:  2009-09-06       Impact factor: 4.372

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