Literature DB >> 26526694

The SIN1-PH Domain Connects mTORC2 to PI3K.

Hai-Xin Yuan1, Kun-Liang Guan2.   

Abstract

The mTOR complex 2, mTORC2, is a critical downstream effector of PI3K that stimulates AGC kinase members, including AKT, PKC, and SGK. Liu and colleagues reported that the pleckstrin homology domain of SIN1, an essential component of mTORC2, directly binds the PI3K product PtdIns(3,4,5)P3 to promote mTORC2 kinase activation and membrane localization, thereby revealing a mechanistic link between PI3K and mTORC2. Cancer Discov; 5(11); 1127-9. ©2015 AACR.See related article by Liu and colleagues, p. 1194. ©2015 American Association for Cancer Research.

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Year:  2015        PMID： 26526694      PMCID： PMC4638136          DOI： 10.1158/2159-8290.CD-15-1125

Source DB:  PubMed          Journal:  Cancer Discov        ISSN： 2159-8274            Impact factor:   39.397


  10 in total

1.  TORC2 plasma membrane localization is essential for cell viability and restricted to a distinct domain.

Authors:  Doris Berchtold; Tobias C Walther
Journal:  Mol Biol Cell       Date:  2009-01-14       Impact factor: 4.138

2.  Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex.

Authors:  D D Sarbassov; David A Guertin; Siraj M Ali; David M Sabatini
Journal:  Science       Date:  2005-02-18       Impact factor: 47.728

3.  PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex.

Authors:  Pengda Liu; Wenjian Gan; Y Rebecca Chin; Kohei Ogura; Jianping Guo; Jinfang Zhang; Bin Wang; John Blenis; Lewis C Cantley; Alex Toker; Bing Su; Wenyi Wei
Journal:  Cancer Discov       Date:  2015-08-20       Impact factor: 39.397

4.  mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s.

Authors:  Maria A Frias; Carson C Thoreen; Jacob D Jaffe; Wayne Schroder; Tom Sculley; Steven A Carr; David M Sabatini
Journal:  Curr Biol       Date:  2006-08-17       Impact factor: 10.834

5.  Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity.

Authors:  Qian Yang; Ken Inoki; Tsuneo Ikenoue; Kun-Liang Guan
Journal:  Genes Dev       Date:  2006-10-15       Impact factor: 11.361

6.  mTORC2 targets AGC kinases through Sin1-dependent recruitment.

Authors:  Angus J M Cameron; Mark D Linch; Adrian T Saurin; Cristina Escribano; Peter J Parker
Journal:  Biochem J       Date:  2011-10-15       Impact factor: 3.857

7.  SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity.

Authors:  Estela Jacinto; Valeria Facchinetti; Dou Liu; Nelyn Soto; Shiniu Wei; Sung Yun Jung; Qiaojia Huang; Jun Qin; Bing Su
Journal:  Cell       Date:  2006-09-07       Impact factor: 41.582

8.  Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling.

Authors:  Tsuneo Ikenoue; Ken Inoki; Qian Yang; Xiaoming Zhou; Kun-Liang Guan
Journal:  EMBO J       Date:  2008-06-19       Impact factor: 11.598

9.  mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1).

Authors:  Juan M García-Martínez; Dario R Alessi
Journal:  Biochem J       Date:  2008-12-15       Impact factor: 3.857

10.  Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis.

Authors:  Pengda Liu; Wenjian Gan; Hiroyuki Inuzuka; Adam S Lazorchak; Daming Gao; Omotooke Arojo; Dou Liu; Lixin Wan; Bo Zhai; Yonghao Yu; Min Yuan; Byeong Mo Kim; Shavali Shaik; Suchithra Menon; Steven P Gygi; Tae Ho Lee; John M Asara; Brendan D Manning; John Blenis; Bing Su; Wenyi Wei
Journal:  Nat Cell Biol       Date:  2013-10-27       Impact factor: 28.824
  10 in total
  20 in total

Review 1.  mTOR function and therapeutic targeting in breast cancer.

Authors:  Stephen H Hare; Amanda J Harvey
Journal:  Am J Cancer Res       Date:  2017-03-01       Impact factor: 6.166

Review 2.  The inositol pyrophosphate pathway in health and diseases.

Authors:  Anutosh Chakraborty
Journal:  Biol Rev Camb Philos Soc       Date:  2017-12-27

3.  Selective mTORC2 Inhibitor Therapeutically Blocks Breast Cancer Cell Growth and Survival.

Authors:  Thomas A Werfel; Shan Wang; Meredith A Jackson; Taylor E Kavanaugh; Meghan Morrison Joly; Linus H Lee; Donna J Hicks; Violeta Sanchez; Paula Gonzalez Ericsson; Kameron V Kilchrist; Somtochukwu C Dimobi; Samantha M Sarett; Dana M Brantley-Sieders; Rebecca S Cook; Craig L Duvall
Journal:  Cancer Res       Date:  2018-01-22       Impact factor: 12.701

Review 4.  mTOR Signaling in Kidney Diseases.

Authors:  Yuan Gui; Chunsun Dai
Journal:  Kidney360       Date:  2020-09-03

5.  Control of CD4+ T Cell Differentiation and Function by PI3K Isoforms.

Authors:  Benjamin Cameron; Syed Aymaan Zaheer; Margarita Dominguez-Villar
Journal:  Curr Top Microbiol Immunol       Date:  2022       Impact factor: 4.737

Review 6.  Regulation of cellular anabolism by mTOR: or how I learned to stop worrying and love translation.

Authors:  J William Deaver; Sara Mata López; Patrick J Ryan; Peter P Nghiem; Steven E Riechman; James D Fluckey
Journal:  Sports Med Health Sci       Date:  2020-11-30

Review 7.  mTOR at the nexus of nutrition, growth, ageing and disease.

Authors:  Grace Y Liu; David M Sabatini
Journal:  Nat Rev Mol Cell Biol       Date:  2020-01-14       Impact factor: 94.444

Review 8.  The role of PI3Kγ in the immune system: new insights and translational implications.

Authors:  Stephen M Lanahan; Matthias P Wymann; Carrie L Lucas
Journal:  Nat Rev Immunol       Date:  2022-03-23       Impact factor: 53.106

9.  Unraveling the regulation of mTORC2 using logical modeling.

Authors:  Kirsten Thobe; Christine Sers; Heike Siebert
Journal:  Cell Commun Signal       Date:  2017-01-19       Impact factor: 5.712

Review 10.  mTORC2: The other mTOR in autophagy regulation.

Authors:  Josué Ballesteros-Álvarez; Julie K Andersen
Journal:  Aging Cell       Date:  2021-07-12       Impact factor: 9.304
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