Literature DB >> 35322259

The role of PI3Kγ in the immune system: new insights and translational implications.

Stephen M Lanahan1, Matthias P Wymann2, Carrie L Lucas3.   

Abstract

Over the past two decades, new insights have positioned phosphoinositide 3-kinase-γ (PI3Kγ) as a context-dependent modulator of immunity and inflammation. Recent advances in protein structure determination and drug development have allowed for generation of highly specific PI3Kγ inhibitors, with the first now in clinical trials for several oncology indications. Recently, a monogenic immune disorder caused by PI3Kγ deficiency was discovered in humans and modelled in mice. Human inactivated PI3Kγ syndrome confirms the immunomodulatory roles of PI3Kγ and strengthens newly defined roles of this molecule in modulating inflammatory cytokine release in macrophages. Here, we review the functions of PI3Kγ in the immune system and discuss how our understanding of its potential as a therapeutic target has evolved.
© 2022. Springer Nature Limited.

Entities:  

Year:  2022        PMID： 35322259     DOI： 10.1038/s41577-022-00701-8

Source DB:  PubMed          Journal:  Nat Rev Immunol        ISSN： 1474-1733            Impact factor:   53.106


  154 in total

Review 1.  Oncogenic PI3K deregulates transcription and translation.

Authors:  Andreas G Bader; Sohye Kang; Li Zhao; Peter K Vogt
Journal:  Nat Rev Cancer       Date:  2005-12       Impact factor: 60.716

2.  A human immunodeficiency caused by mutations in the PIK3R1 gene.

Authors:  Marie-Céline Deau; Lucie Heurtier; Pierre Frange; Felipe Suarez; Christine Bole-Feysot; Patrick Nitschke; Marina Cavazzana; Capucine Picard; Anne Durandy; Alain Fischer; Sven Kracker
Journal:  J Clin Invest       Date:  2015-04-01       Impact factor: 14.808

3.  Pleckstrin domain homology.

Authors:  R J Haslam; H B Koide; B A Hemmings
Journal:  Nature       Date:  1993-05-27       Impact factor: 49.962

Review 4.  Molecular determinants in pleckstrin homology domains that allow specific recognition of phosphoinositides.

Authors:  M A Lemmon; K M Ferguson
Journal:  Biochem Soc Trans       Date:  2001-08       Impact factor: 5.407

5.  Platelet-derived growth factor stimulates synthesis of PtdIns(3,4,5)P3 by activating a PtdIns(4,5)P2 3-OH kinase.

Authors:  P T Hawkins; T R Jackson; L R Stephens
Journal:  Nature       Date:  1992-07-09       Impact factor: 49.962

6.  Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiency.

Authors:  Carrie L Lucas; Hye Sun Kuehn; Fang Zhao; Julie E Niemela; Elissa K Deenick; Umaimainthan Palendira; Danielle T Avery; Leen Moens; Jennifer L Cannons; Matthew Biancalana; Jennifer Stoddard; Weiming Ouyang; David M Frucht; V Koneti Rao; T Prescott Atkinson; Anahita Agharahimi; Ashleigh A Hussey; Les R Folio; Kenneth N Olivier; Thomas A Fleisher; Stefania Pittaluga; Steven M Holland; Jeffrey I Cohen; Joao B Oliveira; Stuart G Tangye; Pamela L Schwartzberg; Michael J Lenardo; Gulbu Uzel
Journal:  Nat Immunol       Date:  2013-10-28       Impact factor: 25.606

7.  An inositol tetrakisphosphate-containing phospholipid in activated neutrophils.

Authors:  A E Traynor-Kaplan; A L Harris; B L Thompson; P Taylor; L A Sklar
Journal:  Nature       Date:  1988-07-28       Impact factor: 49.962

8.  PI3K signalling: the path to discovery and understanding.

Authors:  Bart Vanhaesebroeck; Len Stephens; Phillip Hawkins
Journal:  Nat Rev Mol Cell Biol       Date:  2012-02-23       Impact factor: 94.444

9.  Agammaglobulinemia and absent B lineage cells in a patient lacking the p85α subunit of PI3K.

Authors:  Mary Ellen Conley; A Kerry Dobbs; Anita M Quintana; Amma Bosompem; Yong-Dong Wang; Elaine Coustan-Smith; Amber M Smith; Elena E Perez; Peter J Murray
Journal:  J Exp Med       Date:  2012-02-20       Impact factor: 14.307

10.  Phosphoinositide 3-kinase δ gene mutation predisposes to respiratory infection and airway damage.

Authors:  Ivan Angulo; Oscar Vadas; Fabien Garçon; Edward Banham-Hall; Vincent Plagnol; Timothy R Leahy; Helen Baxendale; Tanya Coulter; James Curtis; Changxin Wu; Katherine Blake-Palmer; Olga Perisic; Deborah Smyth; Mailis Maes; Christine Fiddler; Jatinder Juss; Deirdre Cilliers; Gašper Markelj; Anita Chandra; George Farmer; Anna Kielkowska; Jonathan Clark; Sven Kracker; Marianne Debré; Capucine Picard; Isabelle Pellier; Nada Jabado; James A Morris; Gabriela Barcenas-Morales; Alain Fischer; Len Stephens; Phillip Hawkins; Jeffrey C Barrett; Mario Abinun; Menna Clatworthy; Anne Durandy; Rainer Doffinger; Edwin R Chilvers; Andrew J Cant; Dinakantha Kumararatne; Klaus Okkenhaug; Roger L Williams; Alison Condliffe; Sergey Nejentsev
Journal:  Science       Date:  2013-10-17       Impact factor: 47.728
View more
  1 in total

Review 1.  The immune system as a driver of mitochondrial disease pathogenesis: a review of evidence.

Authors:  Allison Hanaford; Simon C Johnson
Journal:  Orphanet J Rare Dis       Date:  2022-09-02       Impact factor: 4.303
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.