David A Loewenstein1, Maria T Greig2, Rosie Curiel3, Rosemarie Rodriguez2, Meredith Wicklund4, Warren W Barker2, Jacqueline Hidalgo2, Marian Rosado3, Ranjan Duara5. 1. Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami and Center on Aging, Miami, FL; Wien Center for Alzheimer's Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, FL. Electronic address: DLoewenstein@med.miami.edu. 2. Wien Center for Alzheimer's Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, FL. 3. Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami and Center on Aging, Miami, FL. 4. Department of Neurology, University of Florida, Gainesville, FL. 5. Wien Center for Alzheimer's Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, FL; Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL; Department of Neurology, Herbert Wertheim College of Medicine, Florida International University, Miami, FL.
Abstract
OBJECTIVE: To evaluate the relationship between susceptibility to proactive semantic interference (PSI) and retroactive semantic interference (RSI) and brain amyloid load in non-demented elders. METHODS: 27 participants (11 cognitively normal [CN] with subjective memory complaints, 8 CN without memory complaints, and 8 with mild cognitive impairment [MCI]) underwent complete neurological and neuropsychological evaluations. Participants also received the Semantic Interference Test (SIT) and AV-45 amyloid PET imaging. RESULTS: High levels of association were present between total amyloid load, regional amyloid levels, and the PSI measure (in the entire sample and a subsample excluding MCI subjects). RSI and other memory measures showed much weaker associations or no associations with total and regional amyloid load. No associations between amyloid levels and non-memory performance were observed. CONCLUSIONS: In non-demented individuals, vulnerability to PSI was highly associated with total and regional beta-amyloid load and may be an early cognitive marker of brain pathology.
OBJECTIVE: To evaluate the relationship between susceptibility to proactive semantic interference (PSI) and retroactive semantic interference (RSI) and brain amyloid load in non-demented elders. METHODS: 27 participants (11 cognitively normal [CN] with subjective memory complaints, 8 CN without memory complaints, and 8 with mild cognitive impairment [MCI]) underwent complete neurological and neuropsychological evaluations. Participants also received the Semantic Interference Test (SIT) and AV-45 amyloid PET imaging. RESULTS: High levels of association were present between total amyloid load, regional amyloid levels, and the PSI measure (in the entire sample and a subsample excluding MCI subjects). RSI and other memory measures showed much weaker associations or no associations with total and regional amyloid load. No associations between amyloid levels and non-memory performance were observed. CONCLUSIONS: In non-demented individuals, vulnerability to PSI was highly associated with total and regional beta-amyloid load and may be an early cognitive marker of brain pathology.
Authors: Reisa A Sperling; Keith A Johnson; P Murali Doraiswamy; Eric M Reiman; Adam S Fleisher; Marwan N Sabbagh; Carl H Sadowsky; Alan Carpenter; Mat D Davis; Ming Lu; Matthew Flitter; Abhinay D Joshi; Christopher M Clark; Michael Grundman; Mark A Mintun; Daniel M Skovronsky; Michael J Pontecorvo Journal: Neurobiol Aging Date: 2012-08-09 Impact factor: 4.673
Authors: P Murali Doraiswamy; Reisa A Sperling; R Edward Coleman; Keith A Johnson; Eric M Reiman; Mat D Davis; Michael Grundman; Marwan N Sabbagh; Carl H Sadowsky; Adam S Fleisher; Alan Carpenter; Christopher M Clark; Abhinay D Joshi; Mark A Mintun; Daniel M Skovronsky; Michael J Pontecorvo Journal: Neurology Date: 2012-07-11 Impact factor: 9.910
Authors: D A Loewenstein; L D'Elia; A Guterman; C Eisdorfer; F Wilkie; A LaRue; J Mintzer; R Duara Journal: Brain Cogn Date: 1991-05 Impact factor: 2.310
Authors: David A Loewenstein; Amarilis Acevedo; Cheryl Luis; Thomas Crum; Warren W Barker; Ranjan Duara Journal: J Int Neuropsychol Soc Date: 2004-01 Impact factor: 2.892
Authors: David A Loewenstein; Rosie E Curiel; Maria T Greig; Russell M Bauer; Marian Rosado; Dawn Bowers; Meredith Wicklund; Elizabeth Crocco; Michael Pontecorvo; Abhinay D Joshi; Rosemarie Rodriguez; Warren W Barker; Jacqueline Hidalgo; Ranjan Duara Journal: Am J Geriatr Psychiatry Date: 2016-04-04 Impact factor: 4.105
Authors: Rosie E Curiel; Elizabeth Crocco; Marian Rosado; Ranjan Duara; Maria T Greig; Arlene Raffo; David A Loewenstein Journal: J Alzheimers Dis Date: 2016-09-06 Impact factor: 4.472
Authors: Joanne C Beer; Beth E Snitz; Chung-Chou H Chang; David A Loewenstein; Mary Ganguli Journal: Int Psychogeriatr Date: 2018-01-16 Impact factor: 3.878
Authors: R Duara; D A Loewenstein; G Lizarraga; M Adjouadi; W W Barker; M T Greig-Custo; M Rosselli; A Penate; Y F Shea; R Behar; A Ollarves; C Robayo; K Hanson; M Marsiske; S Burke; N Ertekin-Taner; D Vaillancourt; S De Santi; T Golde; DeKosky St Journal: Neuroimage Clin Date: 2019-03-27 Impact factor: 4.881