Habibollah Arefian1, Stefan Hagel2, Steffen Heublein3, Florian Rissner4, André Scherag5, Frank Martin Brunkhorst6, Ross J Baldessarini7, Michael Hartmann3. 1. Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany; Hospital Pharmacy, Jena University Hospital, Jena, Germany. Electronic address: Habibollah.Arefian@med.uni-jena.de. 2. Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany; Center for Infectious Diseases and Infection Control, Jena University Hospital, Jena, Germany; Department of Internal Medicine IV, Jena University Hospital, Jena, Germany. 3. Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany; Hospital Pharmacy, Jena University Hospital, Jena, Germany. 4. Center for Clinical Studies, Jena University Hospital, Jena, Germany. 5. Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany; Research Group, Clinical Epidemiology, Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany. 6. Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany; Center for Clinical Studies, Jena University Hospital, Jena, Germany; Paul-Martini-Clinical Sepsis Research Unit, Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany. 7. Department of Psychiatry, Harvard Medical School, Boston, MA.
Abstract
BACKGROUND: Health care-associated infections (HAIs) can be associated with increased health care costs. We examined extra length of hospital stay (LOS) and associated per diem costs attributable to HAIs in a large academic medical center. METHODS: Data for analysis were acquired in a preinterventional phase of a prospective cohort study (ALERTS) conducted over 12 months in 27 general and 4 intensive care units at Jena University Hospital. HAIs were identified among patients hospitalized for ≥48 hours with at least 1 risk factor for HAI and new antimicrobial therapy; the diagnosis was confirmed by U.S. Centers for Disease Control and Prevention criteria. Extra LOS was estimated by multistate modeling, and associated extra costs were based on average per diem costs for clinical units sampled. RESULTS: Of a total of 22,613 patients hospitalized for ≥48 hours, 893 (3.95%) experienced 1,212 episodes of HAI during 12 months. The associated mean extra LOS ± SEM in general units was 8.45 ± 0.80 days per case and 8.09 ± 0.91 days for patients treated in both general and intensive care units. Additional costs attributable to HAIs were €5,823-€11,840 ($7,453-$15,155) per infected patient. CONCLUSION: HAIs generated substantial extra costs by prolonging hospitalization. Potential clinical and financial savings may be realized by implementing effective infection prevention programs.
BACKGROUND: Health care-associated infections (HAIs) can be associated with increased health care costs. We examined extra length of hospital stay (LOS) and associated per diem costs attributable to HAIs in a large academic medical center. METHODS: Data for analysis were acquired in a preinterventional phase of a prospective cohort study (ALERTS) conducted over 12 months in 27 general and 4 intensive care units at Jena University Hospital. HAIs were identified among patients hospitalized for ≥48 hours with at least 1 risk factor for HAI and new antimicrobial therapy; the diagnosis was confirmed by U.S. Centers for Disease Control and Prevention criteria. Extra LOS was estimated by multistate modeling, and associated extra costs were based on average per diem costs for clinical units sampled. RESULTS: Of a total of 22,613 patients hospitalized for ≥48 hours, 893 (3.95%) experienced 1,212 episodes of HAI during 12 months. The associated mean extra LOS ± SEM in general units was 8.45 ± 0.80 days per case and 8.09 ± 0.91 days for patients treated in both general and intensive care units. Additional costs attributable to HAIs were €5,823-€11,840 ($7,453-$15,155) per infected patient. CONCLUSION: HAIs generated substantial extra costs by prolonging hospitalization. Potential clinical and financial savings may be realized by implementing effective infection prevention programs.
Authors: Masahiko Yazawa; Orsolya Cseprekal; Ryan A Helmick; Manish Talwar; Vasanthi Balaraman; Pradeep S B Podila; Sallyanne Fossey; Sanjaya K Satapathy; James D Eason; Miklos Z Molnar Journal: Ren Fail Date: 2020-11 Impact factor: 2.606
Authors: Jens Hachenberg; Christian Eichler; Ellen Acis; Maximilian Mattes Auer-Schmidt; Mathias Warm; Wolfram Malter; Fabinshy Thangarajah Journal: In Vivo Date: 2021 Jan-Feb Impact factor: 2.155
Authors: Oliver Kumpf; Jan-Peter Braun; Alexander Brinkmann; Hanswerner Bause; Martin Bellgardt; Frank Bloos; Rolf Dubb; Clemens Greim; Arnold Kaltwasser; Gernot Marx; Reimer Riessen; Claudia Spies; Jörg Weimann; Gabriele Wöbker; Elke Muhl; Christian Waydhas Journal: Ger Med Sci Date: 2017-08-01
Authors: Thomas Heister; Martin Wolkewitz; Philip Hehn; Jan Wolff; Markus Dettenkofer; Hajo Grundmann; Klaus Kaier Journal: Cost Eff Resour Alloc Date: 2019-08-01
Authors: Vu Quoc Dat; Vu Thi Lan Huong; Hugo C Turner; Louise Thwaites; H Rogier van Doorn; Behzad Nadjm Journal: PLoS One Date: 2018-10-31 Impact factor: 3.240