Lewis H Kuller1, Oscar L Lopez2, James T Becker3, Yuefang Chang4, Anne B Newman5. 1. Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: kullerl@edc.pitt.edu. 2. Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA. 3. Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA; Department of Psychology, University of Pittsburgh, Pittsburgh, PA, USA. 4. Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA. 5. Department of Epidemiology, Center for Aging and Population Health, University of Pittsburgh, Pittsburgh, PA, USA.
Abstract
INTRODUCTION: Increasing life expectancy has resulted in a larger population of older individuals at risk of dementia. METHODS: The Cardiovascular Health Study-Cognition Study followed 532 participants from 1998-99 (mean age 79) to 2013 (mean age 93) for death and dementia. RESULTS: Risk of death was determined by extent of coronary artery calcium, high-sensitivity cardiac troponin, brain natriuretic peptide, and white matter grade. Significant predictors of dementia were age, apolipoprotein-E4, vocabulary raw score, hippocampal volume, ventricular size, cognitive performance, and number of blocks walked. By 2013, 160 of 532 were alive, including 19 cognitively normal. Those with normal cognition had higher grade education, better cognition test scores, greater hippocampal volume, faster gait speed, and number of blocks walked as compared with survivors who were demented. DISCUSSION: Few survived free of dementia and disability. Prevention and delay of cognitive decline for this older population is an imperative.
INTRODUCTION: Increasing life expectancy has resulted in a larger population of older individuals at risk of dementia. METHODS: The Cardiovascular Health Study-Cognition Study followed 532 participants from 1998-99 (mean age 79) to 2013 (mean age 93) for death and dementia. RESULTS: Risk of death was determined by extent of coronary artery calcium, high-sensitivity cardiac troponin, brain natriuretic peptide, and white matter grade. Significant predictors of dementia were age, apolipoprotein-E4, vocabulary raw score, hippocampal volume, ventricular size, cognitive performance, and number of blocks walked. By 2013, 160 of 532 were alive, including 19 cognitively normal. Those with normal cognition had higher grade education, better cognition test scores, greater hippocampal volume, faster gait speed, and number of blocks walked as compared with survivors who were demented. DISCUSSION: Few survived free of dementia and disability. Prevention and delay of cognitive decline for this older population is an imperative.
Authors: Brenda L Plassman; John W Williams; James R Burke; Tracey Holsinger; Sophiya Benjamin Journal: Ann Intern Med Date: 2010-06-14 Impact factor: 25.391
Authors: K I Erickson; C A Raji; O L Lopez; J T Becker; C Rosano; A B Newman; H M Gach; P M Thompson; A J Ho; L H Kuller Journal: Neurology Date: 2010-10-13 Impact factor: 9.910
Authors: Stephanie Jb Vos; Chengjie Xiong; Pieter Jelle Visser; Mateusz S Jasielec; Jason Hassenstab; Elizabeth A Grant; Nigel J Cairns; John C Morris; David M Holtzman; Anne M Fagan Journal: Lancet Neurol Date: 2013-09-04 Impact factor: 44.182
Authors: Annette L Fitzpatrick; Lewis H Kuller; Oscar L Lopez; Paula Diehr; Ellen S O'Meara; W T Longstreth; José A Luchsinger Journal: Arch Neurol Date: 2009-03
Authors: Oscar L Lopez; William E Klunk; Chester Mathis; Rhaven L Coleman; Julie Price; James T Becker; Howard J Aizenstein; Beth Snitz; Ann Cohen; Milos Ikonomovic; Eric McDade; Steven T DeKosky; Lisa Weissfeld; Lewis H Kuller Journal: Neurology Date: 2014-10-10 Impact factor: 9.910
Authors: L A Farrer; L A Cupples; J L Haines; B Hyman; W A Kukull; R Mayeux; R H Myers; M A Pericak-Vance; N Risch; C M van Duijn Journal: JAMA Date: 1997 Oct 22-29 Impact factor: 56.272
Authors: Dayle McClintock; Desiree Ratner; Meepa Lokuge; David M Owens; Leslie B Gordon; Francis S Collins; Karima Djabali Journal: PLoS One Date: 2007-12-05 Impact factor: 3.240
Authors: Lindsay M Miller; Carmen A Peralta; Annette L Fitzpatrick; Chenkai Wu; Bruce M Psaty; Anne B Newman; Michelle C Odden Journal: J Hypertens Date: 2019-09 Impact factor: 4.844
Authors: Chendi Cui; Akira Sekikawa; Lewis H Kuller; Oscar L Lopez; Anne B Newman; Allison L Kuipers; Rachel H Mackey Journal: J Alzheimers Dis Date: 2018 Impact factor: 4.472
Authors: Lewis H Kuller; Oscar L Lopez; Rachel H Mackey; Caterina Rosano; Daniel Edmundowicz; James T Becker; Anne B Newman Journal: J Am Coll Cardiol Date: 2016-03-08 Impact factor: 24.094
Authors: Lewis H Kuller; Oscar L Lopez; John S Gottdiener; Dalane W Kitzman; James T Becker; Yuefang Chang; Anne B Newman Journal: J Am Heart Assoc Date: 2017-07-22 Impact factor: 5.501
Authors: Oscar L Lopez; James T Becker; YueFang Chang; William E Klunk; Chester Mathis; Julia Price; Howard J Aizenstein; Beth Snitz; Ann D Cohen; Steven T DeKosky; Milos Ikonomovic; M Ilyas Kamboh; Lewis H Kuller Journal: Neurology Date: 2018-04-25 Impact factor: 9.910
Authors: Chendi Cui; Rachel H Mackey; C Elizabeth Shaaban; Lewis H Kuller; Oscar L Lopez; Akira Sekikawa Journal: Alzheimers Dement Date: 2020-08-17 Impact factor: 21.566