Literature DB >> 26518559

Novel bivalent positive allosteric modulators of AMPA receptor.

M I Lavrov1,2, V V Grigor'ev2, S O Bachurin2, V A Palyulin3,4, N S Zefirov1,2.   

Abstract

A positive allosteric modulator of AMPA receptors has been designed using computer-aided molecular modeling techniques. It possessed a record high experimentally confirmed potency in the picomolar concentration range and belongs to a new type of bivalent AMPA receptor ligands containing bicyclo[3.3.1]nonane scaffold. The suggested structure could serve as a basis for further optimization and development of drugs for the treatment of neurodegenerative diseases, cognition enhancement, and improvement of memory.

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Year:  2015        PMID： 26518559     DOI： 10.1134/S1607672915050142

Source DB:  PubMed          Journal:  Dokl Biochem Biophys        ISSN： 1607-6729            Impact factor:   0.788


  12 in total

1.  The binding site for allosteric modulators of AMPA receptor.

Authors:  I G Tikhonova; M I Lavrov; V A Palyulin; N S Zefirov
Journal:  Dokl Biochem Biophys       Date:  2004 Nov-Dec       Impact factor: 0.788

Review 2.  AMPA receptors in the therapeutic management of depression.

Authors:  D Bleakman; A Alt; J M Witkin
Journal:  CNS Neurol Disord Drug Targets       Date:  2007-04       Impact factor: 4.388

3.  Ampakines and the threefold path to cognitive enhancement.

Authors:  Gary Lynch; Christine M Gall
Journal:  Trends Neurosci       Date:  2006-08-07       Impact factor: 13.837

4.  Functional analysis of a novel positive allosteric modulator of AMPA receptors derived from a structure-based drug design strategy.

Authors:  Jonathan E Harms; Morris Benveniste; John K F Maclean; Kathryn M Partin; Craig Jamieson
Journal:  Neuropharmacology       Date:  2012-06-23       Impact factor: 5.250

Review 5.  Excitatory amino acid transmitters.

Authors:  J C Watkins; R H Evans
Journal:  Annu Rev Pharmacol Toxicol       Date:  1981       Impact factor: 13.820

6.  Mechanism of positive allosteric modulators acting on AMPA receptors.

Authors:  Rongsheng Jin; Suzanne Clark; Autumn M Weeks; Joshua T Dudman; Eric Gouaux; Kathryn M Partin
Journal:  J Neurosci       Date:  2005-09-28       Impact factor: 6.167

7.  Structural and functional analysis of two new positive allosteric modulators of GluA2 desensitization and deactivation.

Authors:  David E Timm; Morris Benveniste; Autumn M Weeks; Eric S Nisenbaum; Kathryn M Partin
Journal:  Mol Pharmacol       Date:  2011-05-04       Impact factor: 4.436

8.  AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility.

Authors:  Garrett M Morris; Ruth Huey; William Lindstrom; Michel F Sanner; Richard K Belew; David S Goodsell; Arthur J Olson
Journal:  J Comput Chem       Date:  2009-12       Impact factor: 3.376

Review 9.  In search of novel AMPA potentiators.

Authors:  Pierre Francotte; Pascal de Tullio; Pierre Fraikin; Stéphane Counerotte; Eric Goffin; Bernard Pirotte
Journal:  Recent Pat CNS Drug Discov       Date:  2006-11

Review 10.  AMPA receptor potentiators: application for depression and Parkinson's disease.

Authors:  Michael J O'Neill; Jeffrey M Witkin
Journal:  Curr Drug Targets       Date:  2007-05       Impact factor: 3.465
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  2 in total

1.  New Positive Allosteric Modulator of AMPA Receptors: in vitro and in vivo Studies.

Authors:  V V Grigoriev; M I Lavrov; V L Zamoyski; T L Garibova; V A Palyulin; S O Bachurin
Journal:  Dokl Biochem Biophys       Date:  2019-09       Impact factor: 0.788

2.  Bivalent AMPA receptor positive allosteric modulators of the bis(pyrimidine) series.

Authors:  Anna A Nazarova; Kseniya N Sedenkova; Dmitry S Karlov; Mstislav I Lavrov; Yuri K Grishin; Tamara S Kuznetsova; Vladimir L Zamoyski; Vladimir V Grigoriev; Elena B Averina; Vladimir A Palyulin
Journal:  Medchemcomm       Date:  2019-07-12       Impact factor: 3.597
  2 in total

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