Literature DB >> 31803402

Bivalent AMPA receptor positive allosteric modulators of the bis(pyrimidine) series.

Anna A Nazarova1, Kseniya N Sedenkova1,2, Dmitry S Karlov1,3, Mstislav I Lavrov1,2, Yuri K Grishin1, Tamara S Kuznetsova1, Vladimir L Zamoyski2, Vladimir V Grigoriev1,2, Elena B Averina1,2, Vladimir A Palyulin1,2.   

Abstract

The first example of a novel class of AMPA receptor positive allosteric modulators of the bis(pyrimidine) series having a hydroquinone linker has been obtained and showed a potency to increase kainate-induced currents at subnanomolar concentrations. This journal is © The Royal Society of Chemistry 2019.

Entities:  

Year:  2019        PMID： 31803402      PMCID： PMC6837176          DOI： 10.1039/c9md00262f

Source DB:  PubMed          Journal:  Medchemcomm        ISSN： 2040-2503            Impact factor:   3.597


  28 in total

1.  Novel bivalent positive allosteric modulators of AMPA receptor.

Authors:  M I Lavrov; V V Grigor'ev; S O Bachurin; V A Palyulin; N S Zefirov
Journal:  Dokl Biochem Biophys       Date:  2015-10-31       Impact factor: 0.788

2.  The discovery and characterization of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor potentiator N-{(3S,4S)-4-[4-(5-cyano-2-thienyl)phenoxy]tetrahydrofuran-3-yl}propane-2-sulfonamide (PF-04958242).

Authors:  Christopher L Shaffer; Nandini C Patel; Jacob Schwarz; Renato J Scialis; Yunjing Wei; Xinjun J Hou; Longfei Xie; Kapil Karki; Dianne K Bryce; Sarah M Osgood; William E Hoffmann; John T Lazzaro; Cheng Chang; Dina F McGinnis; Susan M Lotarski; JianHua Liu; R Scott Obach; Mark L Weber; Laigao Chen; Kenneth R Zasadny; Patricia A Seymour; Christopher J Schmidt; Mihály Hajós; Raymond S Hurst; Jayvardhan Pandit; Christopher J O'Donnell
Journal:  J Med Chem       Date:  2015-05-14       Impact factor: 7.446

3.  Design, synthesis, and biological evaluation of novel coxsackievirus B3 inhibitors.

Authors:  Michal Sála; Armando M De Palma; Hubert Hrebabecký; Radim Nencka; Martin Dracínský; Pieter Leyssen; Johan Neyts; Antonín Holý
Journal:  Bioorg Med Chem       Date:  2010-04-29       Impact factor: 3.641

4.  Novel triazine dimers with potent antitrypanosomal activity.

Authors:  Muthusamy Venkatraj; Irene G Salado; Jan Heeres; Jurgen Joossens; Paul J Lewi; Guy Caljon; Louis Maes; Pieter Van der Veken; Koen Augustyns
Journal:  Eur J Med Chem       Date:  2017-11-27       Impact factor: 6.514

5.  Concentration-jump analysis of voltage-dependent conductances activated by glutamate and kainate in neurons of the avian cochlear nucleus.

Authors:  I M Raman; L O Trussell
Journal:  Biophys J       Date:  1995-11       Impact factor: 4.033

6.  Development of novel bis-pyrazole derivatives as antitumor agents with potent apoptosis induction effects and DNA damage.

Authors:  Hong Dai; Shushan Ge; Jing Guo; Shi Chen; Meiling Huang; Jiaying Yang; Siyu Sun; Yong Ling; Yujun Shi
Journal:  Eur J Med Chem       Date:  2017-12-05       Impact factor: 6.514

7.  Orally-effective, long-acting sorbitol dehydrogenase inhibitors: synthesis, structure-activity relationships, and in vivo evaluations of novel heterocycle-substituted piperazino-pyrimidines.

Authors:  Margaret Y Chu-Moyer; William E Ballinger; David A Beebe; Richard Berger; James B Coutcher; Wesley W Day; Jiancheng Li; Banavara L Mylari; Peter J Oates; R Matthew Weekly
Journal:  J Med Chem       Date:  2002-01-17       Impact factor: 7.446

8.  Substituent effects on stereoselectivity of dihalocarbene reactions with cyclohexadiene and on the reactivity of bis-dihalocyclopropanes in electrophilic nitrations en route to pyrimidine N-oxides.

Authors:  Kseniya N Sedenkova; Elena B Averina; Yuri K Grishin; Julia V Kolodyazhnaya; Victor B Rybakov; Tamara S Kuznetsova; Audrey Hughes; Gabriel Dos Passos Gomes; Igor V Alabugin; Nikolay S Zefirov
Journal:  Org Biomol Chem       Date:  2017-11-15       Impact factor: 3.876

9.  The kinetics of the response to glutamate and kainate in neurons of the avian cochlear nucleus.

Authors:  I M Raman; L O Trussell
Journal:  Neuron       Date:  1992-07       Impact factor: 17.173

10.  Chronic Ampakine Treatments Stimulate Dendritic Growth and Promote Learning in Middle-Aged Rats.

Authors:  Julie C Lauterborn; Linda C Palmer; Yousheng Jia; Danielle T Pham; Bowen Hou; Weisheng Wang; Brian H Trieu; Conor D Cox; Svetlana Kantorovich; Christine M Gall; Gary Lynch
Journal:  J Neurosci       Date:  2016-02-03       Impact factor: 6.167
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