Literature DB >> 26515991

Collection of NMR Scalar and Residual Dipolar Couplings Using a Single Experiment.

Leandro F Gil-Silva1, Raquel Santamaría-Fernández1, Armando Navarro-Vázquez2, Roberto R Gil3.   

Abstract

A new DMSO-compatible aligning gel based on cross-linked poly(2-hydroxylethyl methacrylate) (poly-HEMA) has been developed. Due to a significant difference in bulk magnetic susceptibility between the DMSO inside and outside the gel, it is possible to simultaneously collect isotropic and anisotropic NMR data, such as residual dipolar couplings (RDC), in the same NMR tube. RDC-assisted structural analysis of menthol and the alkaloid retrorsine is reported as proof of concept.
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  DMSO; alignment medium; residual dipolar couplings; small molecules; structure elucidation

Year:  2015        PMID： 26515991     DOI： 10.1002/chem.201503449

Source DB:  PubMed          Journal:  Chemistry        ISSN： 0947-6539            Impact factor:   5.236


  7 in total

1.  Unequivocal determination of complex molecular structures using anisotropic NMR measurements.

Authors:  Yizhou Liu; Josep Saurí; Emily Mevers; Mark W Peczuh; Henk Hiemstra; Jon Clardy; Gary E Martin; R Thomas Williamson
Journal:  Science       Date:  2017-04-07       Impact factor: 47.728

2.  The Advanced Floating Chirality Distance Geometry Approach-How Anisotropic NMR Parameters Can Support the Determination of the Relative Configuration of Natural Products.

Authors:  Matthias Köck; Michael Reggelin; Stefan Immel
Journal:  Mar Drugs       Date:  2020-06-24       Impact factor: 5.118

Review 3.  Residual Dipolar Couplings in Structure Determination of Natural Products.

Authors:  Gao-Wei Li; Han Liu; Feng Qiu; Xiao-Juan Wang; Xin-Xiang Lei
Journal:  Nat Prod Bioprospect       Date:  2018-06-25

Review 4.  Computationally-assisted discovery and structure elucidation of natural products.

Authors:  Alfarius Eko Nugroho; Hiroshi Morita
Journal:  J Nat Med       Date:  2019-05-15       Impact factor: 2.343

5.  Unequivocal determination of caulamidines A and B: application and validation of new tools in the structure elucidation tool box.

Authors:  Dennis J Milanowski; Naoya Oku; Laura K Cartner; Heidi R Bokesch; R Thomas Williamson; Josep Saurí; Yizhou Liu; Kirill A Blinov; Yuanqing Ding; Xing-Cong Li; Daneel Ferreira; Larry A Walker; Shabana Khan; Michael T Davies-Coleman; James A Kelley; James B McMahon; Gary E Martin; Kirk R Gustafson
Journal:  Chem Sci       Date:  2017-11-06       Impact factor: 9.825

6.  Relative configuration of micrograms of natural compounds using proton residual chemical shift anisotropy.

Authors:  Nilamoni Nath; Juan Carlos Fuentes-Monteverde; Dawrin Pech-Puch; Jaime Rodríguez; Carlos Jiménez; Markus Noll; Alexander Kreiter; Michael Reggelin; Armando Navarro-Vázquez; Christian Griesinger
Journal:  Nat Commun       Date:  2020-09-01       Impact factor: 14.919

7.  Unequivocal structure confirmation of a breitfussin analog by anisotropic NMR measurements.

Authors:  Ikenna E Ndukwe; Yu-Hong Lam; Sunil K Pandey; Bengt E Haug; Annette Bayer; Edward C Sherer; Kirill A Blinov; R Thomas Williamson; Johan Isaksson; Mikhail Reibarkh; Yizhou Liu; Gary E Martin
Journal:  Chem Sci       Date:  2020-09-21       Impact factor: 9.825
  7 in total

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