Literature DB >> 26515551

Lipid droplets in leukocytes: Organelles linked to inflammatory responses.

Rossana C N Melo1, Peter F Weller2.   

Abstract

Studies on lipid droplets (LDs) in leukocytes have attracted attention due to their association with human diseases. In these cells, LDs are rapidly formed in response to inflammatory stimuli or allergic/inflammatory diseases including infections with parasites and bacteria. Leukocyte LDs are linked to the regulation of immune responses by compartmentalization of several proteins and lipids involved in the control and biosynthesis of inflammatory mediators (eicosanoids). In this mini review, we summarize current knowledge on the composition, structure and function of leukocyte LDs, organelles now considered as structural markers of inflammation.
Copyright © 2015 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Cell activation; Eicosanoids; Electron microscopy; Immune responses; Inflammation; Lipid bodies

Mesh：

Substances：

Year:  2015        PMID： 26515551      PMCID： PMC4744558          DOI： 10.1016/j.yexcr.2015.10.028

Source DB:  PubMed          Journal:  Exp Cell Res        ISSN： 0014-4827            Impact factor:   3.905


  40 in total

1.  Intragranular vesiculotubular compartments are involved in piecemeal degranulation by activated human eosinophils.

Authors:  Rossana C N Melo; Sandra A C Perez; Lisa A Spencer; Ann M Dvorak; Peter F Weller
Journal:  Traffic       Date:  2005-10       Impact factor: 6.215

2.  Co-compartmentalization of MAP kinases and cytosolic phospholipase A2 at cytoplasmic arachidonate-rich lipid bodies.

Authors:  W Yu; P T Bozza; D M Tzizik; J P Gray; J Cassara; A M Dvorak; P F Weller
Journal:  Am J Pathol       Date:  1998-03       Impact factor: 4.307

3.  Allergic challenge-elicited lipid bodies compartmentalize in vivo leukotriene C4 synthesis within eosinophils.

Authors:  Adriana Vieira-de-Abreu; Edson F Assis; Gleice S Gomes; Hugo C Castro-Faria-Neto; Peter F Weller; Christianne Bandeira-Melo; Patrícia T Bozza
Journal:  Am J Respir Cell Mol Biol       Date:  2005-06-09       Impact factor: 6.914

4.  Proteomic analysis of proteins associated with lipid droplets of basal and lipolytically stimulated 3T3-L1 adipocytes.

Authors:  Dawn L Brasaemle; Georgia Dolios; Lawrence Shapiro; Rong Wang
Journal:  J Biol Chem       Date:  2004-08-27       Impact factor: 5.157

5.  Prostaglandin endoperoxide synthase (cyclooxygenase): ultrastructural localization to nonmembrane-bound cytoplasmic lipid bodies in human eosinophils and 3T3 fibroblasts.

Authors:  A M Dvoràk; E S Morgan; D M Tzizik; P F Weller
Journal:  Int Arch Allergy Immunol       Date:  1994-11       Impact factor: 2.749

6.  Pathways for eosinophil lipid body induction: differing signal transduction in cells from normal and hypereosinophilic subjects.

Authors:  P T Bozza; W Yu; J Cassara; P F Weller
Journal:  J Leukoc Biol       Date:  1998-10       Impact factor: 4.962

7.  Ultrastructural immunogold localization of subcellular sites of TNF-alpha in colonic Crohn's disease.

Authors:  W J Beil; P F Weller; M A Peppercorn; S J Galli; A M Dvorak
Journal:  J Leukoc Biol       Date:  1995-09       Impact factor: 4.962

8.  Ultrastructural immunogold localization of prostaglandin endoperoxide synthase (cyclooxygenase) to non-membrane-bound cytoplasmic lipid bodies in human lung mast cells, alveolar macrophages, type II pneumocytes, and neutrophils.

Authors:  A M Dvorak; E Morgan; R P Schleimer; S W Ryeom; L M Lichtenstein; P F Weller
Journal:  J Histochem Cytochem       Date:  1992-06       Impact factor: 2.479

9.  Eosinophil lipid bodies: specific, inducible intracellular sites for enhanced eicosanoid formation.

Authors:  P T Bozza; W Yu; J F Penrose; E S Morgan; A M Dvorak; P F Weller
Journal:  J Exp Med       Date:  1997-09-15       Impact factor: 14.307

10.  Migration of human inflammatory cells into the lung results in the remodeling of arachidonic acid into a triglyceride pool.

Authors:  M Triggiani; A Oriente; M C Seeds; D A Bass; G Marone; F H Chilton
Journal:  J Exp Med       Date:  1995-11-01       Impact factor: 14.307
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  26 in total

1.  The Puzzling Conservation and Diversification of Lipid Droplets from Bacteria to Eukaryotes.

Authors:  Josselin Lupette; Eric Maréchal
Journal:  Results Probl Cell Differ       Date:  2020

2.  Treg Cells Promote the SREBP1-Dependent Metabolic Fitness of Tumor-Promoting Macrophages via Repression of CD8+ T Cell-Derived Interferon-γ.

Authors:  Chang Liu; Maria Chikina; Rahul Deshpande; Ashley V Menk; Ting Wang; Tracy Tabib; Erin A Brunazzi; Kate M Vignali; Ming Sun; Donna B Stolz; Robert A Lafyatis; Wei Chen; Greg M Delgoffe; Creg J Workman; Stacy G Wendell; Dario A A Vignali
Journal:  Immunity       Date:  2019-07-23       Impact factor: 31.745

3.  Lipid Droplet-Associated Proteins (LDAPs) Are Required for the Dynamic Regulation of Neutral Lipid Compartmentation in Plant Cells.

Authors:  Satinder K Gidda; Sunjung Park; Michal Pyc; Olga Yurchenko; Yingqi Cai; Peng Wu; David W Andrews; Kent D Chapman; John M Dyer; Robert T Mullen
Journal:  Plant Physiol       Date:  2016-02-19       Impact factor: 8.340

4.  Lipid bodies accumulation in Leishmania infantum-infected C57BL/6 macrophages.

Authors:  N E Rodríguez; R D Lockard; E A Turcotte; T Araújo-Santos; P T Bozza; V M Borges; M E Wilson
Journal:  Parasite Immunol       Date:  2017-06-16       Impact factor: 2.280

Review 5.  Adaptive and maladaptive roles of lipid droplets in health and disease.

Authors:  Jeffrey D Pressly; Margaret Z Gurumani; Javier T Varona Santos; Alessia Fornoni; Sandra Merscher; Hassan Al-Ali
Journal:  Am J Physiol Cell Physiol       Date:  2022-02-02       Impact factor: 4.249

6.  Lipid Body Organelles within the Parasite Trypanosoma cruzi: A Role for Intracellular Arachidonic Acid Metabolism.

Authors:  Daniel A M Toledo; Natália R Roque; Lívia Teixeira; Erix A Milán-Garcés; Alan B Carneiro; Mariana R Almeida; Gustavo F S Andrade; Jefferson S Martins; Roberto R Pinho; Célio G Freire-de-Lima; Patrícia T Bozza; Heloisa D'Avila; Rossana C N Melo
Journal:  PLoS One       Date:  2016-08-04       Impact factor: 3.240

7.  Natural Schistosoma mansoni Infection in the Wild Reservoir Nectomys squamipes Leads to Excessive Lipid Droplet Accumulation in Hepatocytes in the Absence of Liver Functional Impairment.

Authors:  Kátia B Amaral; Thiago P Silva; Kássia K Malta; Lívia A S Carmo; Felipe F Dias; Mariana R Almeida; Gustavo F S Andrade; Jefferson S Martins; Roberto R Pinho; Sócrates F Costa-Neto; Rosana Gentile; Rossana C N Melo
Journal:  PLoS One       Date:  2016-11-23       Impact factor: 3.240

Review 8.  Microglial Lipid Biology in the Hypothalamic Regulation of Metabolic Homeostasis.

Authors:  Andrew Folick; Suneil K Koliwad; Martin Valdearcos
Journal:  Front Endocrinol (Lausanne)       Date:  2021-05-27       Impact factor: 5.555

9.  Cyclooxygenase (COX)-2 modulates Toxoplasma gondii infection, immune response and lipid droplets formation in human trophoblast cells and villous explants.

Authors:  Guilherme de Souza; Rafaela José Silva; Iliana Claudia Balga Milián; Alessandra Monteiro Rosini; Thádia Evelyn de Araújo; Samuel Cota Teixeira; Mário Cézar Oliveira; Priscila Silva Franco; Claudio Vieira da Silva; José Roberto Mineo; Neide Maria Silva; Eloisa Amália Vieira Ferro; Bellisa Freitas Barbosa
Journal:  Sci Rep       Date:  2021-06-16       Impact factor: 4.379

Review 10.  Host Lipid Bodies as Platforms for Intracellular Survival of Protozoan Parasites.

Authors:  Daniel A M Toledo; Heloísa D'Avila; Rossana C N Melo
Journal:  Front Immunol       Date:  2016-05-03       Impact factor: 7.561
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