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Literature DB >> 35108119

Adaptive and maladaptive roles of lipid droplets in health and disease.

Jeffrey D Pressly^1,2, Margaret Z Gurumani^1,2, Javier T Varona Santos^1,2, Alessia Fornoni^1,2, Sandra Merscher^1,2, Hassan Al-Ali^1,2,3,4,5.

Abstract

Advances in the understanding of lipid droplet biology have revealed essential roles for these organelles in mediating proper cellular homeostasis and stress response. Lipid droplets were initially thought to play a passive role in energy storage. However, recent studies demonstrate that they have substantially broader functions, including protection from reactive oxygen species, endoplasmic reticulum stress, and lipotoxicity. Dysregulation of lipid droplet homeostasis is associated with various pathologies spanning neurological, metabolic, cardiovascular, oncological, and renal diseases. This review provides an overview of the current understanding of lipid droplet biology in both health and disease.

Entities: Chemical

Keywords: cell biology; cellular stress; lipid droplet; lipid dysregulation; lipophagy

Mesh：

Year: 2022 PMID： 35108119 PMCID： PMC8917915 DOI： 10.1152/ajpcell.00239.2021

Source DB: PubMed Journal: Am J Physiol Cell Physiol ISSN： 0363-6143 Impact factor: 4.249

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References

204 in total

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Adaptive and maladaptive roles of lipid droplets in health and disease.

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Review 3. Role of endoplasmic reticulum stress in the pathogenesis of nonalcoholic fatty liver disease.

4. Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes.

Review 5. Interactions between autophagy receptors and ubiquitin-like proteins form the molecular basis for selective autophagy.

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