Literature DB >> 26511761

The Woodchuck, a Nonprimate Model for Immunopathogenesis and Therapeutic Immunomodulation in Chronic Hepatitis B Virus Infection.

Michael Roggendorf1, Anna D Kosinska1, Jia Liu1, Mengji Lu1.   

Abstract

The woodchuck hepatitis virus (WHV) and its host, the eastern woodchuck, is a very valuable model system for hepatitis B virus infection. Many aspects of WHV replication and pathogenesis resemble acute and chronic hepatitis B infection in patients. Since the establishment of immunological tools, woodchucks were used to develop new therapeutic vaccines and immunomodulatory approaches to treat chronic hepadnaviral infections. Combination therapy of nucleos(t)ide analogs, with prime-boost vaccination and triple therapy, including immunomodulatory strategies by blocking the interaction of the programmed death-1 (PD-1) receptor with its ligand inducing a potent T-cell response in chronic WHV carrier woodchucks, suppression of viral replication, and complete elimination of the virus in 30% of the animals. Both strategies may be used for future therapies in patients with chronic hepatitis B.
Copyright © 2015 Cold Spring Harbor Laboratory Press; all rights reserved.

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Year:  2015        PMID： 26511761      PMCID： PMC4665037          DOI： 10.1101/cshperspect.a021451

Source DB:  PubMed          Journal:  Cold Spring Harb Perspect Med        ISSN： 2157-1422            Impact factor:   6.915


  120 in total

1.  PD-1:PD-L1 interactions contribute to the functional suppression of virus-specific CD8+ T lymphocytes in the liver.

Authors:  Holly Maier; Masanori Isogawa; Gordon J Freeman; Francis V Chisari
Journal:  J Immunol       Date:  2007-03-01       Impact factor: 5.422

2.  Replication-incompetent adenoviral vaccine vector elicits effective anti-immunodeficiency-virus immunity.

Authors:  John W Shiver; Tong-Ming Fu; Ling Chen; Danilo R Casimiro; Mary-Ellen Davies; Robert K Evans; Zhi-Qiang Zhang; Adam J Simon; Wendy L Trigona; Sheri A Dubey; Lingyi Huang; Virginia A Harris; Romnie S Long; Xiaoping Liang; Larry Handt; William A Schleif; Lan Zhu; Daniel C Freed; Natasha V Persaud; Liming Guan; Kara S Punt; Aimin Tang; Minchun Chen; Keith A Wilson; Kelly B Collins; Gwendolyn J Heidecker; V Rose Fernandez; Helen C Perry; Joseph G Joyce; Karen M Grimm; James C Cook; Paul M Keller; Denise S Kresock; Henryk Mach; Robert D Troutman; Lynne A Isopi; Donna M Williams; Zheng Xu; Kathryn E Bohannon; David B Volkin; David C Montefiori; Ayako Miura; Georgia R Krivulka; Michelle A Lifton; Marcelo J Kuroda; Jörn E Schmitz; Norman L Letvin; Michael J Caulfield; Andrew J Bett; Rima Youil; David C Kaslow; Emilio A Emini
Journal:  Nature       Date:  2002-01-17       Impact factor: 49.962

3.  Large nontransplanted hepatocellular carcinoma in woodchucks: treatment with adenovirus-mediated delivery of interleukin 12/B7.1 genes.

Authors:  B M Pützer; T Stiewe; F Rödicker; O Schildgen; S Rühm; O Dirsch; M Fiedler; U Damen; B Tennant; C Scherer; F L Graham; M Roggendorf
Journal:  J Natl Cancer Inst       Date:  2001-03-21       Impact factor: 13.506

4.  DNA prime-adenovirus boost immunization induces a vigorous and multifunctional T-cell response against hepadnaviral proteins in the mouse and woodchuck model.

Authors:  Anna D Kosinska; Lena Johrden; Ejuan Zhang; Melanie Fiedler; Anja Mayer; Oliver Wildner; Mengji Lu; Michael Roggendorf
Journal:  J Virol       Date:  2012-06-20       Impact factor: 5.103

5.  Development of a preventive vaccine for Ebola virus infection in primates.

Authors:  N J Sullivan; A Sanchez; P E Rollin; Z Y Yang; G J Nabel
Journal:  Nature       Date:  2000-11-30       Impact factor: 49.962

6.  Establishing a new animal model for hepadnaviral infection: susceptibility of Chinese Marmota-species to woodchuck hepatitis virus infection.

Authors:  Bao-Ju Wang; Yong-Jun Tian; Zhong-Ji Meng; Min Jiang; Bo-Qing Wei; Yuan-Qing Tao; Wei Fan; An-Yi Li; Jun-Jie Bao; Xin-Yu Li; Zheng-Mao Zhang; Zhong-Dong Wang; Hu Wang; Michael Roggendorf; Meng-Ji Lu; Dong-Liang Yang
Journal:  J Gen Virol       Date:  2010-11-17       Impact factor: 3.891

7.  Molecular characterization of CD28 and cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) of woodchuck (Marmota monax).

Authors:  D Yang; M Roggendorf; M Lu
Journal:  Tissue Antigens       Date:  2003-09

Review 8.  Immunomodulation as an option for the treatment of chronic hepatitis B virus infection: preclinical studies in the woodchuck model.

Authors:  Mengji Lu; Stephan Menne; Dongliang Yang; Yang Xu; Michael Roggendorf
Journal:  Expert Opin Investig Drugs       Date:  2007-06       Impact factor: 6.206

9.  Cytotoxic T lymphocytes recognize an HLA-A2-restricted epitope within the hepatitis B virus nucleocapsid antigen.

Authors:  A Penna; F V Chisari; A Bertoletti; G Missale; P Fowler; T Giuberti; F Fiaccadori; C Ferrari
Journal:  J Exp Med       Date:  1991-12-01       Impact factor: 14.307

10.  Enhancing virus-specific immunity in vivo by combining therapeutic vaccination and PD-L1 blockade in chronic hepadnaviral infection.

Authors:  Jia Liu; Ejuan Zhang; Zhiyong Ma; Weimin Wu; Anna Kosinska; Xiaoyong Zhang; Inga Möller; Pia Seiz; Dieter Glebe; Baoju Wang; Dongliang Yang; Mengji Lu; Michael Roggendorf
Journal:  PLoS Pathog       Date:  2014-01-02       Impact factor: 6.823
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  10 in total

1.  Transarterial Chemoembolization in a Woodchuck Model of Hepatocellular Carcinoma.

Authors:  William F Pritchard; David L Woods; Juan A Esparza-Trujillo; Matthew F Starost; Michal Mauda-Havakuk; Andrew S Mikhail; Ivane Bakhutashvili; Shelby Leonard; Elizabeth C Jones; Venkatesh Krishnasamy; John W Karanian; Bradford J Wood
Journal:  J Vasc Interv Radiol       Date:  2020-02-24       Impact factor: 3.464

2.  Evaluation of immune-modulating drugs for use in drug-eluting microsphere transarterial embolization.

Authors:  Andrew S Mikhail; Michal Mauda-Havakuk; Ayele H Negussie; Natalie Hong; Natalie M Hawken; Camella J Carlson; Joshua W Owen; Olga Franco-Mahecha; Paul G Wakim; Andrew L Lewis; William F Pritchard; John W Karanian; Bradford J Wood
Journal:  Int J Pharm       Date:  2022-01-20       Impact factor: 6.510

3.  Transcriptome Analysis and Comparison of Marmota monax and Marmota himalayana.

Authors:  Yanan Liu; Baoju Wang; Lu Wang; Vikash Vikash; Qin Wang; Michael Roggendorf; Mengji Lu; Dongliang Yang; Jia Liu
Journal:  PLoS One       Date:  2016-11-02       Impact factor: 3.240

Review 4.  Interaction between Hepatitis B Virus and Toll-Like Receptors: Current Status and Potential Therapeutic Use for Chronic Hepatitis B.

Authors:  Zhiyong Ma; Qian Cao; Yong Xiong; Ejuan Zhang; Mengji Lu
Journal:  Vaccines (Basel)       Date:  2018-01-16

5.  The Genome Sequence of the Eastern Woodchuck (Marmota monax) - A Preclinical Animal Model for Chronic Hepatitis B.

Authors:  Tyler S Alioto; Fernando Cruz; Jèssica Gómez-Garrido; Miriam Triyatni; Marta Gut; Leonor Frias; Anna Esteve-Codina; Stephan Menne; Anna Kiialainen; Nadine Kumpesa; Fabian Birzele; Roland Schmucki; Ivo G Gut; Olivia Spleiss
Journal:  G3 (Bethesda)       Date:  2019-12-03       Impact factor: 3.154

6.  Ovarian teratoma in a woodchuck (Marmota monax) with hepatocellular carcinoma: radiologic and pathologic features.

Authors:  Johnathan Zeng; Matthew F Starost; Michal Mauda-Havakuk; Andrew S Mikhail; Ari Partanen; Bradford J Wood; John W Karanian; William F Pritchard
Journal:  BMC Vet Res       Date:  2020-11-23       Impact factor: 2.741

7.  Treatment with the Immunomodulator AIC649 in Combination with Entecavir Produces Antiviral Efficacy in the Woodchuck Model of Chronic Hepatitis B.

Authors:  Kyle E Korolowicz; Manasa Suresh; Bin Li; Xu Huang; Changsuek Yon; Xuebing Leng; Bhaskar V Kallakury; Robin D Tucker; Stephan Menne
Journal:  Viruses       Date:  2021-04-09       Impact factor: 5.048

Review 8.  In Vivo Mouse Models for Hepatitis B Virus Infection and Their Application.

Authors:  Yanqin Du; Ruth Broering; Xiaoran Li; Xiaoyong Zhang; Jia Liu; Dongliang Yang; Mengji Lu
Journal:  Front Immunol       Date:  2021-10-29       Impact factor: 7.561

9.  Comparative metabolomics unveils molecular changes and metabolic networks of syringin against hepatitis B mice by untargeted mass spectrometry.

Authors:  Yi-Chang Jiang; Yuan-Feng Li; Ling Zhou; Da-Peng Zhang
Journal:  RSC Adv       Date:  2020-01-02       Impact factor: 4.036

10.  Diverse Virus and Host-Dependent Mechanisms Influence the Systemic and Intrahepatic Immune Responses in the Woodchuck Model of Hepatitis B.

Authors:  Tomasz I Michalak
Journal:  Front Immunol       Date:  2020-05-27       Impact factor: 7.561
  10 in total

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