Tanya L Alderete1, Chloe Autran2, Benjamin E Brekke1, Rob Knight3, Lars Bode2, Michael I Goran4, David A Fields5. 1. Department of Preventive Medicine, University of Southern California, Los Angeles, CA; 2. Departments of Pediatrics and. 3. Departments of Pediatrics and Computer Science and Engineering, University of California, San Diego, CA; and. 4. Department of Preventive Medicine, University of Southern California, Los Angeles, CA; goran@usc.edu. 5. Department of Pediatrics, University of Oklahoma Health Sciences Center and Children's Medical Research Institute Metabolic Research Program, Oklahoma City, OK.
Abstract
BACKGROUND: Evidence linking breastfeeding to reduced risk of developing childhood obesity is inconclusive, yet previous studies have not considered variation in specific components of breast milk that may affect early development. OBJECTIVE: We examined whether differences in the composition of human milk oligosaccharides (HMOs) correlate with infant growth and body composition at 1 and 6 mo of age. DESIGN: Twenty-five mother-infant dyads were recruited from the University Hospital at the University of Oklahoma Health Sciences Center. Infants were breastfed for 6 mo. Breast-milk and infant measures were obtained at 1 and 6 mo of infant age. HMO composition was analyzed by high-pressure liquid chromatography, and infant growth (length and weight) and body composition (percentage fat, total fat, lean mass) were measured by dual-energy X-ray absorptiometry. Relations between HMOs and infant growth and body composition were examined by using multiple linear regression. A priori covariates included maternal prepregnancy body mass index, pregnancy weight gain, and infant age and sex. RESULTS: Higher HMO diversity and evenness at 1 mo were associated with lower total and percentage fat mass at 1 mo. At 1 mo, each 1-μg/mL increase in lacto-N-fucopentaose (LNFP) I was associated with a 0.40-kg lower infant weight (P = 0.03). At 6 mo, each 1-μg/mL increase in LNFPI was associated with a 1.11-kg lower weight (P = 0.03) and a 0.85-g lower lean mass (P = 0.01). At 6 mo, each 1-μg/mL increase in LNFPI was associated with a 0.79-g lower fat mass (P = 0.02), whereas disialyl-lacto-N-tetraose and LNFPII were associated with a 1.92-g (P = 0.02) and 0.42-g (P = 0.02) greater fat mass, respectively. At 6 mo, each 1-μg/mL increase in fucosyl-disialyl-lacto-N-hexaose and lacto-N-neotetraose was associated with 0.04% higher (P = 0.03) and 0.03% lower (P < 0.01) body fat, respectively. CONCLUSION: These findings support the hypothesis that differences in HMO composition in mother's milk are associated with infant growth and body composition. This trial was registered at clinicaltrials.gov as NCT02535637.
BACKGROUND: Evidence linking breastfeeding to reduced risk of developing childhood obesity is inconclusive, yet previous studies have not considered variation in specific components of breast milk that may affect early development. OBJECTIVE: We examined whether differences in the composition of human milk oligosaccharides (HMOs) correlate with infant growth and body composition at 1 and 6 mo of age. DESIGN: Twenty-five mother-infant dyads were recruited from the University Hospital at the University of Oklahoma Health Sciences Center. Infants were breastfed for 6 mo. Breast-milk and infant measures were obtained at 1 and 6 mo of infant age. HMO composition was analyzed by high-pressure liquid chromatography, and infant growth (length and weight) and body composition (percentage fat, total fat, lean mass) were measured by dual-energy X-ray absorptiometry. Relations between HMOs and infant growth and body composition were examined by using multiple linear regression. A priori covariates included maternal prepregnancy body mass index, pregnancy weight gain, and infant age and sex. RESULTS: Higher HMO diversity and evenness at 1 mo were associated with lower total and percentage fat mass at 1 mo. At 1 mo, each 1-μg/mL increase in lacto-N-fucopentaose (LNFP) I was associated with a 0.40-kg lower infant weight (P = 0.03). At 6 mo, each 1-μg/mL increase in LNFPI was associated with a 1.11-kg lower weight (P = 0.03) and a 0.85-g lower lean mass (P = 0.01). At 6 mo, each 1-μg/mL increase in LNFPI was associated with a 0.79-g lower fat mass (P = 0.02), whereas disialyl-lacto-N-tetraose and LNFPII were associated with a 1.92-g (P = 0.02) and 0.42-g (P = 0.02) greater fat mass, respectively. At 6 mo, each 1-μg/mL increase in fucosyl-disialyl-lacto-N-hexaose and lacto-N-neotetraose was associated with 0.04% higher (P = 0.03) and 0.03% lower (P < 0.01) body fat, respectively. CONCLUSION: These findings support the hypothesis that differences in HMO composition in mother's milk are associated with infant growth and body composition. This trial was registered at clinicaltrials.gov as NCT02535637.
Authors: Victor D Torres Roldan; Meritxell Urtecho S; Julia Gupta; Chloe Yonemitsu; Cesar P Cárcamo; Lars Bode; Theresa J Ochoa Journal: Am J Clin Nutr Date: 2020-07-01 Impact factor: 7.045
Authors: Hanna Lagström; Samuli Rautava; Helena Ollila; Anne Kaljonen; Olli Turta; Johanna Mäkelä; Chloe Yonemitsu; Julia Gupta; Lars Bode Journal: Am J Clin Nutr Date: 2020-04-01 Impact factor: 7.045
Authors: Paige K Berger; Jasmine F Plows; Roshonda B Jones; Tanya L Alderete; Chloe Yonemitsu; Ji Hoon Ryoo; Lars Bode; Michael I Goran Journal: Obesity (Silver Spring) Date: 2020-08 Impact factor: 5.002
Authors: Kristina I Rother; Allison C Sylvetsky; Peter J Walter; H Martin Garraffo; David A Fields Journal: J Pediatr Gastroenterol Nutr Date: 2018-03 Impact factor: 2.839