Dustin R Grooms1, Stephen J Page2, James A Onate2. 1. Division of Athletic Training, Ohio University, Athens. 2. School of Health and Rehabilitation Sciences, The Ohio State University, Columbus.
Abstract
BACKGROUND: Anterior cruciate ligament (ACL) injury has multifactorial causes encompassing mechanical, hormonal, exposure, and anatomical factors. Alterations in the central nervous system also play a role, but their influence after injury, recovery, and recurrent injury remain unknown. Modern neuroimaging techniques can be used to elucidate the underlying functional and structural alterations of the brain that predicate the neuromuscular control adaptations associated with ACL injury. This knowledge will further our understanding of the neural adaptations after ACL injury and rehabilitation and in relation to injury risk. In this paper, we describe the measurement of brain activation during knee extension-flexion after ACL injury and reconstruction and 26 days before a contralateral ACL injury. METHODS: Brain functional magnetic resonance imaging data for an ACL-injured participant and a matched control participant were collected and contrasted. RESULTS: Relative to the matched control participant, the ACL-injured participant exhibited increased activation of motor-planning, sensory-processing, and visual-motor control areas. A similar activation pattern was present for the contralateral knee that sustained a subsequent injury. CONCLUSIONS: Bilateral neuroplasticity after ACL injury may contribute to the risk of second injury, or aspects of neurophysiology may be predisposing factors to primary injury. CLINICAL IMPLICATIONS: Sensory-visual-motor function and motor-learning adaptations may provide targets for rehabilitation.
BACKGROUND: Anterior cruciate ligament (ACL) injury has multifactorial causes encompassing mechanical, hormonal, exposure, and anatomical factors. Alterations in the central nervous system also play a role, but their influence after injury, recovery, and recurrent injury remain unknown. Modern neuroimaging techniques can be used to elucidate the underlying functional and structural alterations of the brain that predicate the neuromuscular control adaptations associated with ACL injury. This knowledge will further our understanding of the neural adaptations after ACL injury and rehabilitation and in relation to injury risk. In this paper, we describe the measurement of brain activation during knee extension-flexion after ACL injury and reconstruction and 26 days before a contralateral ACL injury. METHODS: Brain functional magnetic resonance imaging data for an ACL-injured participant and a matched control participant were collected and contrasted. RESULTS: Relative to the matched control participant, the ACL-injured participant exhibited increased activation of motor-planning, sensory-processing, and visual-motor control areas. A similar activation pattern was present for the contralateral knee that sustained a subsequent injury. CONCLUSIONS: Bilateral neuroplasticity after ACL injury may contribute to the risk of second injury, or aspects of neurophysiology may be predisposing factors to primary injury. CLINICAL IMPLICATIONS: Sensory-visual-motor function and motor-learning adaptations may provide targets for rehabilitation.
Entities:
Keywords:
functional magnetic resonance imaging; motor control; neuroplasticity
Authors: K Torquati; V Pizzella; C Babiloni; C Del Gratta; S Della Penna; A Ferretti; R Franciotti; P M Rossini; G L Romani Journal: Neuroimage Date: 2005-02-25 Impact factor: 6.556
Authors: Stephen M Smith; Mark Jenkinson; Mark W Woolrich; Christian F Beckmann; Timothy E J Behrens; Heidi Johansen-Berg; Peter R Bannister; Marilena De Luca; Ivana Drobnjak; David E Flitney; Rami K Niazy; James Saunders; John Vickers; Yongyue Zhang; Nicola De Stefano; J Michael Brady; Paul M Matthews Journal: Neuroimage Date: 2004 Impact factor: 6.556
Authors: Eleni Kapreli; Spyros Athanasopoulos; John Gliatis; Matilda Papathanasiou; Ronald Peeters; Nikolaos Strimpakos; Paul Van Hecke; Athanasios Gouliamos; Stefan Sunaert Journal: Am J Sports Med Date: 2009-12 Impact factor: 6.202
Authors: Adam S Lepley; Dustin R Grooms; Julie P Burland; Steven M Davi; Jeffrey M Kinsella-Shaw; Lindsey K Lepley Journal: Exp Brain Res Date: 2019-03-09 Impact factor: 1.972
Authors: Jed A Diekfuss; Dustin R Grooms; Scott Bonnette; Christopher A DiCesare; Staci Thomas; Ryan P MacPherson; Jonathan D Ellis; Adam W Kiefer; Michael A Riley; Daniel K Schneider; Brooke Gadd; Katie Kitchen; Kim D Barber Foss; Jonathan A Dudley; Weihong Yuan; Gregory D Myer Journal: Psychophysiology Date: 2020-02-13 Impact factor: 4.016
Authors: Dustin R Grooms; Jed A Diekfuss; Jonathan D Ellis; Weihong Yuan; Jonathan Dudley; Kim D Barber Foss; Staci Thomas; Mekibib Altaye; Lacey Haas; Brynne Williams; John M Lanier; Kaley Bridgewater; Gregory D Myer Journal: J Neuroimaging Date: 2019-07-03 Impact factor: 2.486
Authors: Jed A Diekfuss; Dustin R Grooms; Katharine S Nissen; Daniel K Schneider; Kim D Barber Foss; Staci Thomas; Scott Bonnette; Jonathan A Dudley; Weihong Yuan; Danielle L Reddington; Jonathan D Ellis; James Leach; Michael Gordon; Craig Lindsey; Ken Rushford; Carlee Shafer; Gregory D Myer Journal: Braz J Phys Ther Date: 2019-07-17 Impact factor: 3.377
Authors: Dustin R Grooms; Adam W Kiefer; Michael A Riley; Jonathan D Ellis; Staci Thomas; Katie Kitchen; Christopher A DiCesare; Scott Bonnette; Brooke Gadd; Kim D Barber Foss; Weihong Yuan; Paula Silva; Ryan Galloway; Jed A Diekfuss; James Leach; Kate Berz; Gregory D Myer Journal: J Sport Rehabil Date: 2018-09-03 Impact factor: 1.931
Authors: Dustin R Grooms; Ajit Chaudhari; Stephen J Page; Deborah S Nichols-Larsen; James A Onate Journal: J Athl Train Date: 2018-05-11 Impact factor: 2.860
Authors: Manish Anand; Jed A Diekfuss; Scott Bonnette; Ian Short; Matthew Hurn; Dustin R Grooms; Gregory D Myer Journal: Int J Sports Phys Ther Date: 2020-12