Nosayaba Osazuwa-Peters1,2, Sean T Massa3, Kara M Christopher4, Ronald J Walker3, Mark A Varvares3,5. 1. Saint Louis University Cancer Center, 3655 Vista Avenue, Saint Louis, MO, 63110, USA. nosazuwa@slu.edu. 2. Department of Otolaryngology-Head and Neck Surgery, Saint Louis University School of Medicine, 3635 Vista Avenue, 6th Floor Desloge Towers, Saint Louis, MO, 63110-2539, USA. nosazuwa@slu.edu. 3. Department of Otolaryngology-Head and Neck Surgery, Saint Louis University School of Medicine, 3635 Vista Avenue, 6th Floor Desloge Towers, Saint Louis, MO, 63110-2539, USA. 4. Saint Louis University Cancer Center, 3655 Vista Avenue, Saint Louis, MO, 63110, USA. 5. Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, 243 Charles St, Boston, MA, 02114, USA.
Abstract
PURPOSE: To investigate the effect of race and sex on long-term survival of oral and oropharyngeal cancer. METHODS: The Surveillance, Epidemiology and End Results database was queried for adult oral and oropharyngeal cancer patients with at least 25-year follow-up. Kaplan-Meier survival curves and cox proportional hazards model were used to identify differences. RESULTS: Of the 22,162 patients identified, 70.3% were males. Only 8.9% were alive at 25 years post-diagnosis. Black males show the poorest overall and disease-specific survival rates (p < 0.001). After controlling for covariates, Blacks had a 40% higher hazard of mortality compared with Whites (HR 1.40, 95% CI 1.35-1.46), while females had a 9% reduction in mortality risk (HR 0.91, 95% CI 0.88-0.94). CONCLUSIONS: Overall and disease-specific survival is poor for oral and oropharyngeal cancer patients, and Black men fare worst. This illustrates the need for long-term cancer survival plans incorporating disparity effects in overall cancer outcomes.
PURPOSE: To investigate the effect of race and sex on long-term survival of oral and oropharyngeal cancer. METHODS: The Surveillance, Epidemiology and End Results database was queried for adult oral and oropharyngeal cancerpatients with at least 25-year follow-up. Kaplan-Meier survival curves and cox proportional hazards model were used to identify differences. RESULTS: Of the 22,162 patients identified, 70.3% were males. Only 8.9% were alive at 25 years post-diagnosis. Black males show the poorest overall and disease-specific survival rates (p < 0.001). After controlling for covariates, Blacks had a 40% higher hazard of mortality compared with Whites (HR 1.40, 95% CI 1.35-1.46), while females had a 9% reduction in mortality risk (HR 0.91, 95% CI 0.88-0.94). CONCLUSIONS: Overall and disease-specific survival is poor for oral and oropharyngeal cancerpatients, and Black men fare worst. This illustrates the need for long-term cancer survival plans incorporating disparity effects in overall cancer outcomes.
Entities:
Keywords:
Long-term survival; Oral cavity cancer; Oropharyngeal cancer; Outcomes; Racial and sex disparities
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