| Literature DB >> 26505831 |
Ankit Kumar1, Umesh K Singh1, Suvarna G Kini2, Vikas Garg2, Saurabh Agrawal3, Praveen K Tomar4, Prateek Pathak1, Anurag Chaudhary3, Pratibha Gupta5, Amrita Malik4.
Abstract
JNK pathway regulates various physiological processes including inflammatory responses, cell differentiation, cell proliferation, cell death, cell survival and expression of proteins. Deregulation of JNK is linked with various diseases including neurodegenerative disease, autoimmune disease, diabetes, cancer, cardiac hypertrophy and asthma. Three distinct genes JNK1, JNK2 and JNK3 have been identified as regulator of JNK pathway. JNK1 and JNK2 have broad tissue distribution and play a potential role in insulin resistance, inflammation and cell signaling. JNK3 is predominantly found in the CNS neurons, making it an attractive target for neurodegenerative disorders. In this review, we summarize the evidence supporting JNK as a potent therapeutic target, and small molecules from various chemical classes as JNK inhibitors.Entities:
Mesh：
Substances：
Year: 2015 PMID： 26505831 DOI： 10.4155/fmc.15.132
Source DB: PubMed Journal: Future Med Chem ISSN： 1756-8919 Impact factor: 3.808