Literature DB >> 26505558

Targeted delivery of gold nanoparticle contrast agents for reporting gene detection by magnetic resonance imaging.

Luke F Vistain1, Matthew W Rotz1, Richa Rathore1, Adam T Preslar1, Thomas J Meade1.   

Abstract

Detection of protein expression by MRI requires a high payload of Gd(III) per protein binding event. Presented here is a targeted AuDNA nanoparticle capable of delivering several hundred Gd(III) chelates to the HaloTag reporter protein. Incubating this particle with HaloTag-expressing cells produced a 9.4 contrast-to-noise ratio compared to non-expressing cells.

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Year:  2016        PMID： 26505558      PMCID： PMC4679476          DOI： 10.1039/c5cc06565h

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  38 in total

1.  In vivo visualization of gene expression using magnetic resonance imaging.

Authors:  A Y Louie; M M Hüber; E T Ahrens; U Rothbächer; R Moats; R E Jacobs; S E Fraser; T J Meade
Journal:  Nat Biotechnol       Date:  2000-03       Impact factor: 54.908

2.  HaloTag protein-mediated site-specific conjugation of bioluminescent proteins to quantum dots.

Authors:  Yan Zhang; Min-Kyung So; Andreas M Loening; Hequan Yao; Sanjiv S Gambhir; Jianghong Rao
Journal:  Angew Chem Int Ed Engl       Date:  2006-07-24       Impact factor: 15.336

Review 3.  Lanthanide probes for bioresponsive imaging.

Authors:  Marie C Heffern; Lauren M Matosziuk; Thomas J Meade
Journal:  Chem Rev       Date:  2013-12-13       Impact factor: 60.622

4.  Nanoparticle size and surface properties determine the protein corona with possible implications for biological impacts.

Authors:  Martin Lundqvist; Johannes Stigler; Giuliano Elia; Iseult Lynch; Tommy Cedervall; Kenneth A Dawson
Journal:  Proc Natl Acad Sci U S A       Date:  2008-09-22       Impact factor: 11.205

5.  Antibody-linked spherical nucleic acids for cellular targeting.

Authors:  Ke Zhang; Liangliang Hao; Sarah J Hurst; Chad A Mirkin
Journal:  J Am Chem Soc       Date:  2012-09-28       Impact factor: 15.419

6.  Ferritin as an endogenous MRI reporter for noninvasive imaging of gene expression in C6 glioma tumors.

Authors:  Batya Cohen; Hagit Dafni; Gila Meir; Alon Harmelin; Michal Neeman
Journal:  Neoplasia       Date:  2005-02       Impact factor: 5.715

Review 7.  Gold nanoparticles for biology and medicine.

Authors:  David A Giljohann; Dwight S Seferos; Weston L Daniel; Matthew D Massich; Pinal C Patel; Chad A Mirkin
Journal:  Angew Chem Int Ed Engl       Date:  2010-04-26       Impact factor: 15.336

8.  MagA is sufficient for producing magnetic nanoparticles in mammalian cells, making it an MRI reporter.

Authors:  Omar Zurkiya; Anthony W S Chan; Xiaoping Hu
Journal:  Magn Reson Med       Date:  2008-06       Impact factor: 4.668

9.  Thrombus imaging with fibrin-specific gadolinium-based MR contrast agent EP-2104R: results of a phase II clinical study of feasibility.

Authors:  Josef Vymazal; Elmar Spuentrup; Gerardo Cardenas-Molina; Andrea J Wiethoff; Michael G Hartmann; Peter Caravan; Edward C Parsons
Journal:  Invest Radiol       Date:  2009-11       Impact factor: 6.016

10.  Polyethylene glycol backfilling mitigates the negative impact of the protein corona on nanoparticle cell targeting.

Authors:  Qin Dai; Carl Walkey; Warren C W Chan
Journal:  Angew Chem Int Ed Engl       Date:  2014-04-02       Impact factor: 15.336
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  8 in total

1.  A Markedly Improved Synthetic Approach for the Preparation of Multifunctional Au-DNA Nanoparticle Conjugates Modified with Optical and MR Imaging Probes.

Authors:  Matthew W Rotz; Robert J Holbrook; Keith W MacRenaris; Thomas J Meade
Journal:  Bioconjug Chem       Date:  2018-10-10       Impact factor: 4.774

Review 2.  Click Chemistry in the Development of Contrast Agents for Magnetic Resonance Imaging.

Authors:  Sudath Hapuarachchige; Dmitri Artemov
Journal:  Top Magn Reson Imaging       Date:  2016-10

3.  Molecular Magnetic Resonance Imaging with Gd(III)-Based Contrast Agents: Challenges and Key Advances.

Authors:  Hao Li; Thomas J Meade
Journal:  J Am Chem Soc       Date:  2019-10-17       Impact factor: 15.419

4.  Cell Penetration Profiling Using the Chloroalkane Penetration Assay.

Authors:  Leila Peraro; Kirsten L Deprey; Matthew K Moser; Zhongju Zou; Haydn L Ball; Beth Levine; Joshua A Kritzer
Journal:  J Am Chem Soc       Date:  2018-08-31       Impact factor: 15.419

5.  Nanodiamond-Gadolinium(III) Aggregates for Tracking Cancer Growth In Vivo at High Field.

Authors:  Nikhil Rammohan; Keith W MacRenaris; Laura K Moore; Giacomo Parigi; Daniel J Mastarone; Lisa M Manus; Laura M Lilley; Adam T Preslar; Emily A Waters; Abigail Filicko; Claudio Luchinat; Dean Ho; Thomas J Meade
Journal:  Nano Lett       Date:  2016-11-15       Impact factor: 11.189

6.  Effect of Magnetic Coupling on Water Proton Relaxivity in a Series of Transition Metal GdIII Complexes.

Authors:  Laura M Lilley; Kang Du; Matthew D Krzyaniak; Giacomo Parigi; Claudio Luchinat; T David Harris; Thomas J Meade
Journal:  Inorg Chem       Date:  2018-05-01       Impact factor: 5.165

7.  Second-Generation Drosophila Chemical Tags: Sensitivity, Versatility, and Speed.

Authors:  Ben Sutcliffe; Julian Ng; Thomas O Auer; Mathias Pasche; Richard Benton; Gregory S X E Jefferis; Sebastian Cachero
Journal:  Genetics       Date:  2017-02-16       Impact factor: 4.562

8.  Controlled in-cell activation of RNA therapeutics using bond-cleaving bio-orthogonal chemistry.

Authors:  Irfan Khan; Leah M Seebald; Neil M Robertson; Mehmet V Yigit; Maksim Royzen
Journal:  Chem Sci       Date:  2017-06-14       Impact factor: 9.825
  8 in total

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