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Literature DB >> 26504630

Precancerous esophageal epithelia are associated with significantly increased scattering coefficients.

Jing-Wei Su¹, Yang-Hsien Lin¹, Chun-Ping Chiang², Jang-Ming Lee³, Chao-Mao Hsieh¹, Min-Shu Hsieh⁴, Pei-Wen Yang³, Chen-Ping Wang⁵, Ping-Huei Tseng⁶, Yi-Chia Lee⁶, Kung-Bin Sung⁷.

Abstract

The progression of epithelial precancers into cancer is accompanied by changes of tissue and cellular structures in the epithelium. Correlations between the structural changes and scattering coefficients of esophageal epithelia were investigated using quantitative phase images and the scattering-phase theorem. An ex vivo study of 14 patients demonstrated that the average scattering coefficient of precancerous epithelia was 37.8% higher than that of normal epithelia from the same patient. The scattering coefficients were highly correlated with morphological features including the cell density and the nuclear-to-cytoplasmic ratio. A high interpatient variability in scattering coefficients was observed and suggests identifying precancerous lesions based on the relative change in scattering coefficients.

Entities: Disease Species

Keywords: (170.0180) Microscopy; (170.4580) Optical diagnostics for medicine; (170.6935) Tissue characterization; (290.7050) Turbid media

Year: 2015 PMID： 26504630 PMCID： PMC4605039 DOI： 10.1364/BOE.6.003795

Source DB: PubMed Journal: Biomed Opt Express ISSN： 2156-7085 Impact factor: 3.732

32 in total

1. Detection of preinvasive cancer cells.

Authors: V Backman; M B Wallace; L T Perelman; J T Arendt; R Gurjar; M G Müller; Q Zhang; G Zonios; E Kline; J A McGilligan; S Shapshay; T Valdez; K Badizadegan; J M Crawford; M Fitzmaurice; S Kabani; H S Levin; M Seiler; R R Dasari; I Itzkan; J Van Dam; M S Feld; T McGillican
Journal: Nature Date: 2000-07-06 Impact factor: 49.962

2. Light scattering from normal and dysplastic cervical cells at different epithelial depths: finite-difference time-domain modeling with a perfectly matched layer boundary condition.

Authors: Dizem Arifler; Martial Guillaud; Anita Carraro; Anais Malpica; Michele Follen; Rebecca Richards-Kortum
Journal: J Biomed Opt Date: 2003-07 Impact factor: 3.170

3. Novel algorithm of processing optical coherence tomography images for differentiation of biological tissue pathologies.

Authors: Ilya V Turchin; Ekaterina A Sergeeva; Lev S Dolin; Vladislav A Kamensky; Natalia M Shakhova; Rebecca Richards-Kortum
Journal: J Biomed Opt Date: 2005 Nov-Dec Impact factor: 3.170

4. Determination of optical scattering properties of highly-scattering media in optical coherence tomography images.

Authors: David Levitz; Lars Thrane; Michael Frosz; Peter Andersen; Claus Andersen; Stefan Andersson-Engels; Jurga Valanciunaite; Johannes Swartling; Peter Hansen
Journal: Opt Express Date: 2004-01-26 Impact factor: 3.894

5. Accuracy of the Born approximation in calculating the scattering coefficient of biological continuous random media.

Authors: Ilker R Capoğlu; Jeremy D Rogers; Allen Taflove; Vadim Backman
Journal: Opt Lett Date: 2009-09-01 Impact factor: 3.776

6. Investigating the spectral characteristics of backscattering from heterogeneous spherical nuclei using broadband finite-difference time-domain simulations.

Authors: Guo-Shan Chao; Kung-Bin Sung
Journal: J Biomed Opt Date: 2010 Jan-Feb Impact factor: 3.170

Precancerous esophageal epithelia are associated with significantly increased scattering coefficients.

1. Detection of preinvasive cancer cells.

2. Light scattering from normal and dysplastic cervical cells at different epithelial depths: finite-difference time-domain modeling with a perfectly matched layer boundary condition.

3. Novel algorithm of processing optical coherence tomography images for differentiation of biological tissue pathologies.

4. Determination of optical scattering properties of highly-scattering media in optical coherence tomography images.

5. Accuracy of the Born approximation in calculating the scattering coefficient of biological continuous random media.

6. Investigating the spectral characteristics of backscattering from heterogeneous spherical nuclei using broadband finite-difference time-domain simulations.

7. Digital holographic microtomography for high-resolution refractive index mapping of live cells.

8. Nonscalar elastic light scattering from continuous random media in the Born approximation.

9. Scattering-phase theorem: anomalous diffraction by forward-peaked scattering media.

10. Broadband ultraviolet-visible optical property measurement in layered turbid media.

1. Holotomography: Refractive Index as an Intrinsic Imaging Contrast for 3-D Label-Free Live Cell Imaging.

2. Reconstruction of Optical Vector-Fields With Applications in Endoscopic Imaging.

3. Label-free optical quantification of structural alterations in Alzheimer's disease.

4. Full-field quantitative phase and polarisation-resolved imaging through an optical fibre bundle.

5. Investigation of water bonding status of normal and psoriatic skin in vivo using diffuse reflectance spectroscopy.