Literature DB >> 2649880

A cDNA clone encoding part of the major 25,000-dalton surface membrane antigen of adult Schistosoma mansoni.

M Knight1, C Kelly, V Rodrigues, X Yi, A Wamachi, S R Smithers, A J Simpson.   

Abstract

Immunoscreening of an adult Schistosoma mansoni cDNA expression library, using antibodies raised against purified adult worm tegumental surface membranes, identified a recombinant clone containing a 141-bp insert. Antibodies raised against the recombinant antigen bound specifically to the tegument of adult worms and immunoprecipitated the major 25,000-dalton surface membrane antigen as well as a 22,000-dalton nascent polypeptide generated by cell-free translation of adult S. mansoni mRNA. The mature 25,000-dalton antigen was found to be precipitated by antibodies from infected mice, rats and humans.

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Year:  1989        PMID： 2649880     DOI： 10.1007/bf00931812

Source DB:  PubMed          Journal:  Parasitol Res        ISSN： 0932-0113            Impact factor:   2.289


  16 in total

1.  IgM antibodies recognizing carbohydrate epitopes shared between schistosomula and miracidia of Schistosoma mansoni that block in vitro killing.

Authors:  X Y Yi; P Omer-Ali; C Kelly; A J Simpson; S R Smithers
Journal:  J Immunol       Date:  1986-12-15       Impact factor: 5.422

2.  Schistosoma mansoni: characterization of two protective monoclonal antibodies.

Authors:  Q D Bickle; B J Andrews; M G Taylor
Journal:  Parasite Immunol       Date:  1986-01       Impact factor: 2.280

3.  The infection of laboratory hosts with cercariae of Schistosoma mansoni and the recovery of the adult worms.

Authors:  S R Smithers; R J Terry
Journal:  Parasitology       Date:  1965-11       Impact factor: 3.234

4.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors:  U K Laemmli
Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

5.  Surface proteins and antigens of adult Schistosoma mansoni tegumental membranes detached onto poly-lysine coated beads.

Authors:  G Payares; W H Evans
Journal:  Mol Biochem Parasitol       Date:  1987-03       Impact factor: 1.759

6.  A monoclonal antibody raised against adult Schistosoma mansoni which recognizes a surface antigen on schistosomula.

Authors:  C A Tavares; R de Rossi; G Payares; A J Simpson; D J McLaren; S R Smithers
Journal:  Z Parasitenkd       Date:  1984

7.  Acquired resistance to Schistosoma haematobium in the baboon (Papio anubis) after cercarial exposure and adult worm transplantation.

Authors:  G Webbe; C James; G S Nelson; S R Smithers; R J Terry
Journal:  Ann Trop Med Parasitol       Date:  1976-12

8.  DNA sequencing with chain-terminating inhibitors.

Authors:  F Sanger; S Nicklen; A R Coulson
Journal:  Proc Natl Acad Sci U S A       Date:  1977-12       Impact factor: 11.205

9.  Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,3,4,6-tetrachloro-3a,6a-diphrenylglycoluril.

Authors:  P J Fraker; J C Speck
Journal:  Biochem Biophys Res Commun       Date:  1978-02-28       Impact factor: 3.575

10.  Cell-free synthesis of Schistosoma mansoni surface antigens: stage specificity of their expression.

Authors:  M Knight; A J Simpson; G Payares; M Chaudri; S R Smithers
Journal:  EMBO J       Date:  1984-01       Impact factor: 11.598
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  4 in total

1.  Immunoblotting identifies additional antigens recognised by mice protectively vaccinated with adult Schistosoma mansoni tegumental membranes.

Authors:  S R Smithers; F Hackett; V Braga; A J Simpson
Journal:  Parasitol Res       Date:  1990       Impact factor: 2.289

2.  Partial characterization and kinetics of expression of Sm15, a Schistosoma mansoni tegumental antigen.

Authors:  F G Abath; P Hagan; S A Jeffs; A J Simpson
Journal:  Parasitol Res       Date:  1994       Impact factor: 2.289

Review 3.  Development of the Brazilian Anti Schistosomiasis Vaccine Based on the Recombinant Fatty Acid Binding Protein Sm14 Plus GLA-SE Adjuvant.

Authors:  Miriam Tendler; Marilia Almeida; Andrew Simpson
Journal:  Front Immunol       Date:  2015-05-12       Impact factor: 7.561

4.  Sm25, a major schistosome tegumental glycoprotein, is dependent on palmitic acid for membrane attachment.

Authors:  E J Pearce; A I Magee; S R Smithers; A J Simpson
Journal:  EMBO J       Date:  1991-10       Impact factor: 11.598
  4 in total

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