OBJECTIVE: To investigate possible effects of the C9orf72 repeat expansion before disease onset, we assessed brain morphology in asymptomatic carriers. METHODS: Aiming to diminish the effects of genetic variation between subjects, apart from the C9orf72 repeat expansion, 16 carriers of the repeat expansion were compared with 23 noncarriers from the same large family with a history of amyotrophic lateral sclerosis (ALS). Cortical thickness, subcortical volumes, and white matter connectivity, as assessed from high-resolution T1-weighted and diffusion-weighted MRIs, were evaluated. For comparison, we included 14 C9orf72 carriers with ALS and 28 healthy, unrelated controls. RESULTS: We found temporal, parietal, and occipital regions to be thinner (p < 0.05) and the left caudate and putamen to be smaller (p < 0.05) in asymptomatic carriers compared with noncarriers. Cortical thinning of the primary motor cortex and decreased connectivity of white matter pathways (global, corticospinal tract, and corpus callosum) were observed in patients with C9orf72-associated ALS, but not in asymptomatic carriers. CONCLUSIONS: Asymptomatic C9orf72 carriers show cortical and subcortical differences compared with noncarriers from the same family, possibly effects of the C9orf72 repeat expansion on the brain. Of note, changes in the primary motor regions and motor-related tracts were found exclusively in patients with ALS, indicating that such motor changes may be a disease phenomenon.
OBJECTIVE: To investigate possible effects of the C9orf72 repeat expansion before disease onset, we assessed brain morphology in asymptomatic carriers. METHODS: Aiming to diminish the effects of genetic variation between subjects, apart from the C9orf72 repeat expansion, 16 carriers of the repeat expansion were compared with 23 noncarriers from the same large family with a history of amyotrophic lateral sclerosis (ALS). Cortical thickness, subcortical volumes, and white matter connectivity, as assessed from high-resolution T1-weighted and diffusion-weighted MRIs, were evaluated. For comparison, we included 14 C9orf72 carriers with ALS and 28 healthy, unrelated controls. RESULTS: We found temporal, parietal, and occipital regions to be thinner (p < 0.05) and the left caudate and putamen to be smaller (p < 0.05) in asymptomatic carriers compared with noncarriers. Cortical thinning of the primary motor cortex and decreased connectivity of white matter pathways (global, corticospinal tract, and corpus callosum) were observed in patients with C9orf72-associated ALS, but not in asymptomatic carriers. CONCLUSIONS: Asymptomatic C9orf72 carriers show cortical and subcortical differences compared with noncarriers from the same family, possibly effects of the C9orf72 repeat expansion on the brain. Of note, changes in the primary motor regions and motor-related tracts were found exclusively in patients with ALS, indicating that such motor changes may be a disease phenomenon.
Authors: Stacey Li Hi Shing; Mary Clare McKenna; We Fong Siah; Rangariroyashe H Chipika; Orla Hardiman; Peter Bede Journal: Brain Imaging Behav Date: 2021-01-05 Impact factor: 3.978
Authors: Tania F Gendron; Jeannie Chew; Jeannette N Stankowski; Lindsey R Hayes; Yong-Jie Zhang; Mercedes Prudencio; Yari Carlomagno; Lillian M Daughrity; Karen Jansen-West; Emilie A Perkerson; Aliesha O'Raw; Casey Cook; Luc Pregent; Veronique Belzil; Marka van Blitterswijk; Lilia J Tabassian; Chris W Lee; Mei Yue; Jimei Tong; Yuping Song; Monica Castanedes-Casey; Linda Rousseau; Virginia Phillips; Dennis W Dickson; Rosa Rademakers; John D Fryer; Beth K Rush; Otto Pedraza; Ana M Caputo; Pamela Desaro; Carla Palmucci; Amelia Robertson; Michael G Heckman; Nancy N Diehl; Edythe Wiggs; Michael Tierney; Laura Braun; Jennifer Farren; David Lacomis; Shafeeq Ladha; Christina N Fournier; Leo F McCluskey; Lauren B Elman; Jon B Toledo; Jennifer D McBride; Cinzia Tiloca; Claudia Morelli; Barbara Poletti; Federica Solca; Alessandro Prelle; Joanne Wuu; Jennifer Jockel-Balsarotti; Frank Rigo; Christine Ambrose; Abhishek Datta; Weixing Yang; Denitza Raitcheva; Giovanna Antognetti; Alexander McCampbell; John C Van Swieten; Bruce L Miller; Adam L Boxer; Robert H Brown; Robert Bowser; Timothy M Miller; John Q Trojanowski; Murray Grossman; James D Berry; William T Hu; Antonia Ratti; Bryan J Traynor; Matthew D Disney; Michael Benatar; Vincenzo Silani; Jonathan D Glass; Mary Kay Floeter; Jeffrey D Rothstein; Kevin B Boylan; Leonard Petrucelli Journal: Sci Transl Med Date: 2017-03-29 Impact factor: 17.956
Authors: Michael J Strong; Sharon Abrahams; Laura H Goldstein; Susan Woolley; Paula Mclaughlin; Julie Snowden; Eneida Mioshi; Angie Roberts-South; Michael Benatar; Tibor HortobáGyi; Jeffrey Rosenfeld; Vincenzo Silani; Paul G Ince; Martin R Turner Journal: Amyotroph Lateral Scler Frontotemporal Degener Date: 2017-01-05 Impact factor: 4.092