Literature DB >> 26497600

SERPINB12 Is a Slow-Binding Inhibitor of Granzyme A and Hepsin.

Jason Z Niehaus1, Mark T Miedel1, Misty Good1, Allyson N Wyatt1, Stephen C Pak1, Gary A Silverman1, Cliff J Luke1.   

Abstract

The clade B/intracellular serpins protect cells from peptidase-mediated injury by forming covalent complexes with their targets. SERPINB12 is expressed in most tissues, especially at cellular interfaces with the external environment. This wide tissue distribution pattern is similar to that of granzyme A (GZMA). Because SERPINB12 inhibits trypsin-like serine peptidases, we determined whether it might also neutralize GZMA. SERPINB12 formed a covalent complex with GZMA and inhibited the enzyme with typical serpin slow-binding kinetics. SERPINB12 also inhibited Hepsin. SERPINB12 may function as an endogenous inhibitor of these peptidases.

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Year:  2015        PMID： 26497600      PMCID： PMC4900762          DOI： 10.1021/acs.biochem.5b01042

Source DB:  PubMed          Journal:  Biochemistry        ISSN： 0006-2960            Impact factor:   3.162


  34 in total

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Review 4.  The behavior and significance of slow-binding enzyme inhibitors.

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